RNF41 and TTC1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		RNF41	TTC1
Description		ring finger protein 41	tetratricopeptide repeat domain 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network	Cytoplasm Peroxisomal Membrane Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Protein-macromolecule Adaptor Activity Unfolded Protein Binding
	Biological Process	Protein Polyubiquitination Autophagy Apoptotic Process Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Protein Folding Inflammatory Response Positive Regulation Of Inflammatory Response Chemokine-mediated Signaling Pathway Positive Regulation Of Neuroinflammatory Response
Pathways		Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 31619474) Height ( 34054925)	Diastolic blood pressure ( 27841878) Hemoglobin levels ( 32327693) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		39 interacting genes: ADRB2 AIRIM AP2S1 APP ARL6IP4 BIRC6 CLEC9A ERBB3 ERBB4 IRS4 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 RAD23A RFC4 RNF166 RRM2B SRR TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 ZAP70	19 interacting genes: ACY1 CRY2 CYB5R1 GNA15 GNAI2 GNAQ GNAS HRAS HSPA1A HSPA4 HSPA8 NDE1 PSTPIP1 RNF41 SH3BP4 SOX5 SPP1 SREBF2 TGFBR1
Entrez ID		10193	7265
HPRD ID		11520	11881
Ensembl ID		ENSG00000181852	ENSG00000113312
Uniprot IDs		F8VSB6 Q9H4P4	Q99614
PDB IDs		2FZP 2GWF
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Receptor Complex Protein Polyubiquitination Neuregulin Receptor Activity Protein Ubiquitination Melatonin Receptor Activity Post-translational Protein Modification Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Free Ubiquitin Chain Polymerization Protein Modification Process Negative Regulation Of Signal Transduction Amacrine Cell Differentiation Negative Regulation Of Cell Communication Macromolecule Metabolic Process Negative Regulation Of Signaling Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Calcium-mediated Signaling Axon Development Regulation Of Viral Process Ubiquitin-protein Transferase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Regulation Of Amyloid Fibril Formation Protein K63-linked Ubiquitination	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Receptor Binding Heterotrimeric G-protein Complex G Protein-coupled Acetylcholine Receptor Signaling Pathway Nucleotide Binding ATP-dependent Protein Folding Chaperone C3HC4-type RING Finger Domain Binding Acetylcholine Receptor Signaling Pathway Extracellular Exosome GTPase Activity Postsynaptic Signal Transduction ATP-dependent Protein Disaggregase Activity GTP Binding Response To Hormone Regulation Of Cell Communication Regulation Of Signaling G Protein Activity Signal Transduction Perinuclear Region Of Cytoplasm Negative Regulation Of Growth Regulation Of Signal Transduction Response To Unfolded Protein Response To Lipid Cellular Response To Laminar Fluid Shear Stress Cellular Response To Acidic PH Response To Laminar Fluid Shear Stress Chaperone-mediated Protein Complex Assembly Response To Acidic PH Cellular Response To PH Response To Prostaglandin E Regulation Of Growth Protein Refolding Entrainment Of Circadian Clock Regulation Of Multicellular Organismal Process Regulation Of Lipid Transport Cellular Response To Fluid Shear Stress Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Lipid Transport Negative Regulation Of Cell Growth FAD Binding Response To PH Regulation Of Cell Growth Cytosol Photoreactive Repair Regulation Of Transport Response To Fluid Shear Stress Negative Regulation Of Cell Population Proliferation Chaperone-mediated Autophagy Translocation Complex Disassembly
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