RNF41 and KDM3B

Number of citations of the paper that reports this interaction (PubMedID 28542518)
52

Data Source:
BioGRID (two hybrid, affinity chromatography technology, proximity labelling technology)

		RNF41	KDM3B
Description		ring finger protein 41	lysine demethylase 3B
Image
GO Annotations	Cellular Component	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Coregulator Activity Zinc Ion Binding Oxidoreductase Activity Chromatin DNA Binding Histone H3K9 Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3K9me/H3K9me2 Demethylase Activity
	Biological Process	Protein Polyubiquitination Autophagy Apoptotic Process Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II
Pathways		Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation	HDMs demethylate histones
Drugs
Diseases
GWAS		Asthma ( 31619474) Height ( 34054925)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756 34002096) Bipolar I disorder ( 31043756) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) HIV-1 susceptibility ( 25786224) Menarche (age at onset) ( 21102462 25231870) Response to radiotherapy in prostate cancer (toxicity, urinary frequency) ( 27515689) Schizophrenia ( 25056061)
Interacting Genes		39 interacting genes: ADRB2 AIRIM AP2S1 APP ARL6IP4 BIRC6 CLEC9A ERBB3 ERBB4 IRS4 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 RAD23A RFC4 RNF166 RRM2B SRR TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 ZAP70	6 interacting genes: CREBBP H3-4 RNF41 SPAG8 UBC ZNF512B
Entrez ID		10193	51780
HPRD ID		11520	11055
Ensembl ID		ENSG00000181852	ENSG00000120733
Uniprot IDs		F8VSB6 Q9H4P4	Q7LBC6
PDB IDs		2FZP 2GWF	4C8D 5R7X 5RAA 5RAB 5RAC 5RAD 5RAE 5RAF 5RAG 5RAH 5RAI 5RAJ 5RAK 5RAL 5RAM 5RAN 5RAO 5RAP 5RAQ 5RAR 5RAS 5RAU 5RAV 5RAW 5RAX 5RAY 5RAZ 5RB0 5RB1 5RB2 5RB3 5RB4 5RB5 5RB6 5RB7 6RBJ
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Receptor Complex Protein Polyubiquitination Neuregulin Receptor Activity Protein Ubiquitination Melatonin Receptor Activity Post-translational Protein Modification Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Free Ubiquitin Chain Polymerization Protein Modification Process Negative Regulation Of Signal Transduction Amacrine Cell Differentiation Negative Regulation Of Cell Communication Macromolecule Metabolic Process Negative Regulation Of Signaling Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Calcium-mediated Signaling Axon Development Regulation Of Viral Process Ubiquitin-protein Transferase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Regulation Of Amyloid Fibril Formation Protein K63-linked Ubiquitination	Cell Adhesion Molecule Binding Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Endoplasmic Reticulum Tubular Network
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