RNF41 and UBASH3B

Number of citations of the paper that reports this interaction (PubMedID 26390156)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RNF41	UBASH3B
Description		ring finger protein 41	ubiquitin associated and SH3 domain containing B
Image
GO Annotations	Cellular Component	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network	Nucleus Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphoprotein Binding
	Biological Process	Protein Polyubiquitination Autophagy Apoptotic Process Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Signal Transduction Negative Regulation Of Signal Transduction Platelet Activation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Regulation Of Osteoclast Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Platelet Aggregation Negative Regulation Of Platelet Aggregation
Pathways		Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 31619474) Height ( 34054925)	Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Blood urea nitrogen levels ( 31152163) Cholesterol, total ( 25961943 20686565 24097068) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Eye length ( 30174134) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 33339817) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol levels ( 32203549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Pemphigus vulgaris ( 29857070) Serum immune biomarker levels ( 32066700) Stroke ( 26089329) Systolic blood pressure ( 30578418) Total cholesterol levels ( 28334899)
Interacting Genes		39 interacting genes: ADRB2 AIRIM AP2S1 APP ARL6IP4 BIRC6 CLEC9A ERBB3 ERBB4 IRS4 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 RAD23A RFC4 RNF166 RRM2B SRR TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 ZAP70	51 interacting genes: BBC3 CBL CBLB CCDC74B CUL3 DAZAP2 DISC1 DLGAP2 DMRT3 DOC2A DTX3 EFS FAM168A HOXB2 INCA1 JAK2 KAT5 KDM1A KHDRBS1 KPRP LMO2 LZTS2 MAP3K1 PIAS2 PKP4 PRKN PRR35 PSMB1 PTPN21 RCHY1 REL RNF216 RNF41 SHC1 SLC25A48 SPRY2 SYK TCF4 TEPSIN TNKS TP53BP2 UBB UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H VPS37B WASL
Entrez ID		10193	84959
HPRD ID		11520	16463
Ensembl ID		ENSG00000181852	ENSG00000154127
Uniprot IDs		F8VSB6 Q9H4P4	Q8TF42
PDB IDs		2FZP 2GWF	2CPW 2E5K 5VR6 5W5G 8U5M 8U7E
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Receptor Complex Protein Polyubiquitination Neuregulin Receptor Activity Protein Ubiquitination Melatonin Receptor Activity Post-translational Protein Modification Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Free Ubiquitin Chain Polymerization Protein Modification Process Negative Regulation Of Signal Transduction Amacrine Cell Differentiation Negative Regulation Of Cell Communication Macromolecule Metabolic Process Negative Regulation Of Signaling Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Calcium-mediated Signaling Axon Development Regulation Of Viral Process Ubiquitin-protein Transferase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Regulation Of Amyloid Fibril Formation Protein K63-linked Ubiquitination	Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Protein Modification Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin Protein Ligase Activity Proteolysis Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Protein Ubiquitination Protein Autoubiquitination Protein Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Transferase Activity Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Protein Monoubiquitination Receptor Tyrosine Kinase Binding Positive Regulation Of Metabolic Process Protein Binding Regulation Of Protein Metabolic Process Protein K11-linked Ubiquitination Phosphotyrosine Residue Binding Cytosol SH3 Domain Binding Regulation Of Primary Metabolic Process Regulation Protein Catabolic Process At Postsynapse Apoptotic Signaling Pathway Macromolecule Metabolic Process Organelle Localization P53 Binding Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Protein Polymerization Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?