CCNE1 and SMARCC1

Number of citations of the paper that reports this interaction (PMID 9891079)
41

Data Source:
HPRD (in vivo, in vitro)

		CCNE1	SMARCC1
Gene Name		cyclin E1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
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Gene Ontology Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytosol	Nuclear Chromatin XY Body Nucleoplasm SWI/SNF Complex Protein Complex NpBAF Complex NBAF Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Androgen Receptor Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding Protein N-terminus Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Initiation Protein Phosphorylation Wnt Signaling Pathway Androgen Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cell Division Regulation Of Cell Cycle	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Insulin Receptor Signaling Pathway Organ Morphogenesis ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		E2F mediated regulation of DNA replication DNA Damage/Telomere Stress Induced Senescence Cellular Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes p53-Dependent G1/S DNA damage checkpoint G0 and Early G1 S Phase Cyclin E associated events during G1/S transition Cell Cycle, Mitotic p53-Dependent G1 DNA Damage Response SCF(Skp2)-mediated degradation of p27/p21 G1/S Transition G1/S-Specific Transcription Cell Cycle Checkpoints Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G1-G1/S phases G1/S DNA Damage Checkpoints	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS		Bladder cancer ( 20972438)
Protein-Protein Interactions		46 interactors: AR ARHGEF5 ARID4A BRCA2 BTRC CABLES1 CALM1 CCT4 CDC25A CDC34 CDC6 CDK1 CDK2 CDK3 CDKN1A COIL CUL3 FBXW7 FOXM1 GSK3B H1F0 HERC5 HIST1H1A HIST1H1B MARCKS MCM3 MRE11A MYBL2 NBN PIN1 POLD1 PRC1 PRKAR1A RB1 RBL1 RBL2 RBX1 REL RHOBTB3 RRN3 SKP2 SMARCA4 SMARCC1 SMARCD3 TP73 UBTF	23 interactors: ADAMTSL4 ADD1 AKT1 CCNE1 CEBPB FANCA GATA1 ITCH KLF1 MSL1 MYC NEDD4 NONO NR3C1 OTX1 PLSCR1 PRMT5 RELB SIN3A SMARCA4 SMARCD3 SP1 SRC
Entrez ID		898	6599
HPRD ID		00455	03435
Ensembl ID		ENSG00000105173	ENSG00000173473
Uniprot IDs		P24864	Q58EY4 Q92922
PDB IDs		1W98	2YUS
Enriched GO Terms of Interacting Partners?		Cell Cycle Regulation Of Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Organelle Organization Chromosome Organization Positive Regulation Of Cellular Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Chromatin Organization G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression DNA Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Cell Cycle Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process DNA Replication Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of DNA Replication Heterocycle Metabolic Process Cell Division Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Chromatin Modification Cell Cycle Checkpoint Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Phase Transition	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Organ Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Myeloid Cell Differentiation Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Metabolic Process Chromatin Organization Immune System Process In Utero Embryonic Development Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Biosynthetic Process Chromatin Modification Erythrocyte Differentiation System Development Negative Regulation Of Signaling Regulation Of Metabolic Process Hemopoiesis Erythrocyte Homeostasis Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Homeostasis Of Number Of Cells Negative Regulation Of Cellular Metabolic Process Regulation Of Binding Negative Regulation Of Gene Expression RNA Metabolic Process Immune System Development Myeloid Cell Homeostasis Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Chromosome Organization
Tagcloud ?		augments becomes cd31 cdkn1a cdkn2a clorgyline combines conjugate degrades dye emt goals hypoxic inactivating infrared m30 maoa micromolar modern moiety monoamine monoamines multidisciplinary neurotransmitters nfkb nmi oncogenes pca pharmacology	ae1 baf155 baf180 baf47 brg1 brm concurrent cytokeratin eosin epithelioid es hematoxylin hpb1 ini1 ini1expression mating nonfermentation pbrm1 pure reclassified rhabdoid snf2l2 snf5l4 sucrose switch vimentin
Tagcloud (Difference) ?		augments becomes cd31 cdkn1a cdkn2a clorgyline combines conjugate degrades dye emt goals hypoxic inactivating infrared m30 maoa micromolar modern moiety monoamine monoamines multidisciplinary neurotransmitters nfkb nmi oncogenes pca pharmacology	ae1 baf155 baf180 baf47 brg1 brm concurrent cytokeratin eosin epithelioid es hematoxylin hpb1 ini1 ini1expression mating nonfermentation pbrm1 pure reclassified rhabdoid snf2l2 snf5l4 sucrose switch vimentin
Tagcloud (Intersection) ?