CCNE1 and UBTF

Number of citations of the paper that reports this interaction (PMID 10202152)
43

Data Source:
BioGRID (enzymatic study)

		CCNE1	UBTF
Gene Name		cyclin E1	upstream binding transcription factor, RNA polymerase I
Image
Gene Ontology Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytosol	Nucleoplasm Nucleolus
	Molecular Function	Transcription Coactivator Activity Protein Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Androgen Receptor Binding	DNA Binding Chromatin Binding Protein Binding Poly(A) RNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Initiation Protein Phosphorylation Wnt Signaling Pathway Androgen Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cell Division Regulation Of Cell Cycle	Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase I Promoter
Pathways		E2F mediated regulation of DNA replication DNA Damage/Telomere Stress Induced Senescence Cellular Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes p53-Dependent G1/S DNA damage checkpoint G0 and Early G1 S Phase Cyclin E associated events during G1/S transition Cell Cycle, Mitotic p53-Dependent G1 DNA Damage Response SCF(Skp2)-mediated degradation of p27/p21 G1/S Transition G1/S-Specific Transcription Cell Cycle Checkpoints Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G1-G1/S phases G1/S DNA Damage Checkpoints	NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression RNA Polymerase I Promoter Opening
Drugs
Diseases
GWAS		Bladder cancer ( 20972438)
Protein-Protein Interactions		46 interactors: AR ARHGEF5 ARID4A BRCA2 BTRC CABLES1 CALM1 CCT4 CDC25A CDC34 CDC6 CDK1 CDK2 CDK3 CDKN1A COIL CUL3 FBXW7 FOXM1 GSK3B H1F0 HERC5 HIST1H1A HIST1H1B MARCKS MCM3 MRE11A MYBL2 NBN PIN1 POLD1 PRC1 PRKAR1A RB1 RBL1 RBL2 RBX1 REL RHOBTB3 RRN3 SKP2 SMARCA4 SMARCC1 SMARCD3 TP73 UBTF	31 interactors: CCNA2 CCND1 CCNE1 CD3EAP CDK2 CDK4 CENPC CHGB CREBBP CSNK2A1 IRS1 IRS2 LEF1 MAD1L1 MAPK1 MAPK3 MDM2 POLR1E RB1 RBL2 RUNX2 SERPINH1 SMURF1 TAF1 TAF1A TAF1B TAF1C TAF1D TBP TCOF1 ZMYM2
Entrez ID		898	7343
HPRD ID		00455	02814
Ensembl ID		ENSG00000105173	ENSG00000108312
Uniprot IDs		P24864	P17480
PDB IDs		1W98	1K99 1L8Y 1L8Z 2HDZ
Enriched GO Terms of Interacting Partners?		Cell Cycle Regulation Of Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Organelle Organization Chromosome Organization Positive Regulation Of Cellular Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Chromatin Organization G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression DNA Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Cell Cycle Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process DNA Replication Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of DNA Replication Heterocycle Metabolic Process Cell Division Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Chromatin Modification Cell Cycle Checkpoint Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Phase Transition	Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter DNA-templated Transcription, Initiation DNA-templated Transcription, Elongation Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Chromatin Silencing At RDNA Cellular Macromolecule Biosynthetic Process Gene Expression Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Regulation Of Cell Cycle Phase Transition RNA Metabolic Process Regulation Of Transcription, DNA-templated Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Chromatin Silencing Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Checkpoint Regulation Of RNA Metabolic Process Cell Division Positive Regulation Of Cellular Biosynthetic Process Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of Cell Cycle Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Gene Expression, Epigenetic Negative Regulation Of Mitotic Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Cycle Checkpoint Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway RRNA Transcription
Tagcloud ?		augments becomes cd31 cdkn1a cdkn2a clorgyline combines conjugate degrades dye emt goals hypoxic inactivating infrared m30 maoa micromolar modern moiety monoamine monoamines multidisciplinary neurotransmitters nfkb nmi oncogenes pca pharmacology
Tagcloud (Difference) ?		augments becomes cd31 cdkn1a cdkn2a clorgyline combines conjugate degrades dye emt goals hypoxic inactivating infrared m30 maoa micromolar modern moiety monoamine monoamines multidisciplinary neurotransmitters nfkb nmi oncogenes pca pharmacology
Tagcloud (Intersection) ?