CCNE1 and POLD1

Number of citations of the paper that reports this interaction (PubMedID 9545286)
0

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		CCNE1	POLD1
Description		cyclin E1	DNA polymerase delta 1, catalytic subunit
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Cyclin E1-CDK2 Complex	Nucleotide-excision Repair Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Membrane Aggresome Delta DNA Polymerase Complex
	Molecular Function	Protein Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding Chromatin Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Nuclease Activity Exonuclease Activity Protein Binding Zinc Ion Binding 3'-5'-DNA Exonuclease Activity 3'-5' Exonuclease Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Enzyme Binding DNA Polymerase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Replication Initiation Protein Phosphorylation Homologous Chromosome Pairing At Meiosis Wnt Signaling Pathway Regulation Of Protein Localization Cell Division Regulation Of Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mesenchymal Stem Cell Proliferation	DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling DNA Damage Response Response To UV Cellular Response To UV DNA Replication Proofreading Fatty Acid Homeostasis Error-free Translesion Synthesis DNA Biosynthetic Process
Pathways		G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response PTK6 Regulates Cell Cycle Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) RHOBTB3 ATPase cycle	Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Cytosolic iron-sulfur cluster assembly Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases		Laryngeal cancer Gastric cancer
GWAS		Adult body size ( 32376654) Bladder cancer ( 20972438 24163127) Body mass index ( 25673413) Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Diastolic blood pressure ( 27841878 28135244) Medication use (diuretics) ( 31015401) Response to fenofibrate (total cholesterol levels) ( 27002377) Spatial processing ( 31596458) Walking pace ( 33128006)	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Obesity-related traits ( 23251661)
Interacting Genes		71 interacting genes: AKT1 AR ARHGEF5 ARID4A ARIH1 ARNT AURKA BRCA2 BTRC CABLES1 CALM1 CCND2 CCT4 CDC25A CDC6 CDK1 CDK2 CDK3 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C COIL CUL3 FBXW7 FGFR4 FOXM1 FZR1 GLIS2 GMNC GRM1 GSK3B H1-0 H1-1 H1-5 HERC5 KAT2A KPNB1 LATS2 LINC00664 MARCKS MCM3 MRE11 MYBL2 MYC NBN NF2 PIN1 POLD1 PRC1 PRKAR1A PTPA RASSF1 RB1 RBL1 RBL2 REL RHOBTB3 RRN3 SKP2 SMARCA4 SMARCC1 SMARCD3 SPOP STK11 TERT TP73 TSC1 UBTF	21 interacting genes: ADAMTSL4 ATR CCND3 CCNE1 CDK2 CDK4 CEP126 CHGB GINS4 LASP1 MCPH1 PCNA POLD2 POLD3 POLD4 SUMO2 TREX2 TRIM55 WRNIP1 XRCC5 YPEL3
Entrez ID		898	5424
HPRD ID		00455	08882
Ensembl ID		ENSG00000105173	ENSG00000062822
Uniprot IDs		A0A0G3DHS8 P24864 V5W5X2	A0A087WYJ2 M0R2B7 P28340 Q308M6 Q59FA0
PDB IDs		1W98 5L2W 7KJS 7XQK 8H4R 8H6P 8H6T 8VQ3 8VQ4	6S1M 6S1N 6S1O 6TNY 6TNZ 9EKB
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Nucleus Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of DNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Population Proliferation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA Metabolic Process Cyclin Binding Negative Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Cell Population Proliferation Cellular Response To Stress Cell Division Regulation Of Protein Localization To Nucleus Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Modification Process Regulation Of Signal Transduction Regulation Of Chromosome Organization Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Macromolecule Metabolic Process G2/M Transition Of Mitotic Cell Cycle	DNA Replication DNA Repair DNA Biosynthetic Process DNA Synthesis Involved In DNA Repair DNA Metabolic Process DNA-templated DNA Replication DNA Damage Response DNA Strand Elongation Involved In DNA Replication Cyclin-dependent Protein Kinase Holoenzyme Complex Delta DNA Polymerase Complex DNA Strand Elongation Telomere Maintenance Telomere Organization Mitotic Cell Cycle Phase Transition Cyclin D3-CDK4 Complex Cellular Response To Stress Cell Cycle Phase Transition Nucleic Acid Metabolic Process Chromosome, Telomeric Region DNA-directed DNA Polymerase Activity G1/S Transition Of Mitotic Cell Cycle Translesion Synthesis Cell Cycle G1/S Phase Transition Cyclin E1-CDK2 Complex DNA Synthesis Involved In UV-damage Excision Repair Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Leading Strand Elongation Zeta DNA Polymerase Complex Nucleobase-containing Compound Biosynthetic Process Postreplication Repair Regulation Of DNA Replication Nucleoplasm Nucleobase-containing Compound Metabolic Process MutLalpha Complex Binding Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Error-prone Translesion Synthesis Chromosome Organization Protein Localization To Chromosome, Telomeric Region Regulation Of DNA-templated DNA Replication Initiation Double-strand Break Repair Response To Stress Regulation Of Cell Cycle Phase Transition Regulation Of Chromosome Organization Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Biosynthetic Process Regulation Of DNA Metabolic Process
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