CCNE1 and MARCKS

Number of citations: 26 (PubMedID 10359664)
Data Source: BioGRID (enzymatic study)

		CCNE1	MARCKS
Name		cyclin E1	myristoylated alanine rich protein kinase C substrate
Structure			No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Cyclin E1-CDK2 Complex	Nucleoplasm Cytoplasm Endoplasmic Reticulum Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cilium Cell Cortex Actin Cytoskeleton Membrane Nuclear Speck Cell Junction Actin Filament Bundle Germinal Vesicle Organelle Extracellular Exosome
	Molecular Function	Protein Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding	Actin Binding Protein Kinase C Binding Calmodulin Binding Identical Protein Binding Actin Filament Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Replication Initiation Protein Phosphorylation Homologous Chromosome Pairing At Meiosis Wnt Signaling Pathway Regulation Of Protein Localization Cell Division Regulation Of Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mesenchymal Stem Cell Proliferation	Apoptotic Process Mitochondrion Organization Actin Filament Organization Central Nervous System Development Neural Tube Development Neurogenesis Response To Endoplasmic Reticulum Stress Actin Filament Bundle Assembly Actin Crosslink Formation
Pathways		G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response PTK6 Regulates Cell Cycle Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) RHOBTB3 ATPase cycle	Acetylcholine regulates insulin secretion
Diseases		Laryngeal cancer Gastric cancer	None
GWAS		Adult body size ( 32376654 ) Bladder cancer ( 20972438 24163127 ) Body mass index ( 25673413 ) Breast cancer ( 29058716 ) Breast cancer (estrogen-receptor negative) ( 29058716 ) Diastolic blood pressure ( 27841878 28135244 ) Medication use (diuretics) ( 31015401 ) Response to fenofibrate (total cholesterol levels) ( 27002377 ) Spatial processing ( 31596458 ) Walking pace ( 33128006 )	Alcohol dependence ( 33290381 ) Bipolar disorder (body mass index interaction) ( 24322204 ) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308 ) Household income ( 31844048 ) Household income (MTAG) ( 31844048 ) Type 2 diabetes ( 25760438 )
Interacting Genes		71 interacting genes: AKT1 AR ARHGEF5 ARID4A ARIH1 ARNT AURKA BRCA2 BTRC CABLES1 CALM1 CCND2 CCT4 CDC25A CDC6 CDK1 CDK2 CDK3 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C COIL CUL3 FBXW7 FGFR4 FOXM1 FZR1 GLIS2 GMNC GRM1 GSK3B H1-0 H1-1 H1-5 HERC5 KAT2A KPNB1 LATS2 LINC00664 MARCKS MCM3 MRE11 MYBL2 MYC NBN NF2 PIN1 POLD1 PRC1 PRKAR1A PTPA RASSF1 RB1 RBL1 RBL2 REL RHOBTB3 RRN3 SKP2 SMARCA4 SMARCC1 SMARCD3 SPOP STK11 TERT TP73 TSC1 UBTF	11 interacting genes: CALM2 CCNE1 CDK2 CDK4 CTSB NMT1 PKN1 PRKCA PRKCB SPP1 TOB1
Entrez ID		898	4082
HPRD ID		00455	07519
Ensembl ID		ENSG00000105173	ENSG00000277443
Uniprot IDs		A0A0G3DHS8 P24864 V5W5X2	P29966 Q6NVI1
PDB IDs		1W98 5L2W 7KJS 7XQK 8H4R 8H6P 8H6T 8VQ3 8VQ4	Not available
GO Terms Enriched among Interactors		Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Nucleus Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of DNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Population Proliferation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA Metabolic Process Cyclin Binding Negative Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Cell Population Proliferation Cellular Response To Stress Cell Division Regulation Of Protein Localization To Nucleus Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Modification Process Regulation Of Signal Transduction Regulation Of Chromosome Organization Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Macromolecule Metabolic Process G2/M Transition Of Mitotic Cell Cycle	Histone H3T6 Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Kinase Activity Cyclin E1-CDK2 Complex Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Phosphorylation Protein Serine Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Phosphorylation Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Serine/threonine Kinase Activity Protein Kinase C Signaling Protein Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Mitotic Nuclear Membrane Disassembly Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Bone Resorption Nuclear Membrane Disassembly Membrane Disassembly Calyx Of Held Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Hormone Secretion Decidualization Nuclear Androgen Receptor Binding Presynaptic Cytosol Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cyclin Binding Regulation Of Mitotic Cell Cycle Protein Modification Process Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Hormone Levels Regulation Of Bone Resorption Regulation Of Cell Cycle Transferase Activity Response To Ketone Regulation Of Bone Remodeling Calcium Channel Regulator Activity Regulation Of Nucleobase-containing Compound Metabolic Process Protein Kinase C Binding Nuclear Membrane Organization G2/M Transition Of Mitotic Cell Cycle Regulation Of Hormone Secretion Chromatin Remodeling Cell Cycle G2/M Phase Transition Myristoyltransferase Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury