CCNE1 and FOXM1

Number of citations of the paper that reports this interaction (PMID 15024056)
65

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CCNE1	FOXM1
Gene Name		cyclin E1	forkhead box M1
Image
Gene Ontology Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytosol	Nucleoplasm Cytoplasm
	Molecular Function	Transcription Coactivator Activity Protein Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Androgen Receptor Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Initiation Protein Phosphorylation Wnt Signaling Pathway Androgen Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cell Division Regulation Of Cell Cycle	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Regulation Of Cell Growth Vasculogenesis Liver Development DNA Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Cell Cycle Positive Regulation Of Cell Proliferation Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Cell Proliferation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ras Protein Signal Transduction Regulation Of Cell Cycle Regulation Of Cell Cycle Arrest Negative Regulation Of Cell Aging Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Double-strand Break Repair
Pathways		E2F mediated regulation of DNA replication DNA Damage/Telomere Stress Induced Senescence Cellular Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes p53-Dependent G1/S DNA damage checkpoint G0 and Early G1 S Phase Cyclin E associated events during G1/S transition Cell Cycle, Mitotic p53-Dependent G1 DNA Damage Response SCF(Skp2)-mediated degradation of p27/p21 G1/S Transition G1/S-Specific Transcription Cell Cycle Checkpoints Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G1-G1/S phases G1/S DNA Damage Checkpoints	Cyclin A/B1 associated events during G2/M transition G2/M Transition Mitotic G2-G2/M phases Cell Cycle, Mitotic Polo-like kinase mediated events
Drugs
Diseases
GWAS		Bladder cancer ( 20972438)
Protein-Protein Interactions		46 interactors: AR ARHGEF5 ARID4A BRCA2 BTRC CABLES1 CALM1 CCT4 CDC25A CDC34 CDC6 CDK1 CDK2 CDK3 CDKN1A COIL CUL3 FBXW7 FOXM1 GSK3B H1F0 HERC5 HIST1H1A HIST1H1B MARCKS MCM3 MRE11A MYBL2 NBN PIN1 POLD1 PRC1 PRKAR1A RB1 RBL1 RBL2 RBX1 REL RHOBTB3 RRN3 SKP2 SMARCA4 SMARCC1 SMARCD3 TP73 UBTF	13 interactors: BANP CCNE1 CDK1 CDK2 CDK4 CDK6 CHEK2 CREBBP OS9 STAT3 SUMO1 UBE2I ZBTB3
Entrez ID		898	2305
HPRD ID		00455	03823
Ensembl ID		ENSG00000105173	ENSG00000111206
Uniprot IDs		P24864	A8K591 Q08050 Q53Y49
PDB IDs		1W98	3G73
Enriched GO Terms of Interacting Partners?		Cell Cycle Regulation Of Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Organelle Organization Chromosome Organization Positive Regulation Of Cellular Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Chromatin Organization G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression DNA Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Cell Cycle Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process DNA Replication Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of DNA Replication Heterocycle Metabolic Process Cell Division Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Chromatin Modification Cell Cycle Checkpoint Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Phase Transition	Cell Division Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Regulation Of Gene Expression Cell Cycle Positive Regulation Of Gene Expression Cellular Protein Modification Process Cell Cycle Process Positive Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Protein Localization To Organelle Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Proteasomal Protein Catabolic Process Regulation Of Metabolic Process Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Mitotic DNA Damage Checkpoint Phosphorylation Mitotic Nuclear Division Mitotic DNA Integrity Checkpoint Regulation Of Nitrogen Compound Metabolic Process Chromatin Organization Protein Phosphorylation G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Protein Metabolic Process Cellular Macromolecule Catabolic Process Protein Metabolic Process Organelle Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Damage Checkpoint Cellular Response To Stress Mitotic Cell Cycle Checkpoint Protein Sumoylation Protein Localization To Nucleus
Tagcloud ?		augments becomes cd31 cdkn1a cdkn2a clorgyline combines conjugate degrades dye emt goals hypoxic inactivating infrared m30 maoa micromolar modern moiety monoamine monoamines multidisciplinary neurotransmitters nfkb nmi oncogenes pca pharmacology	axis caenorhabditis catalytic coexpressed collectively contributes driven elegans evolutionarily ezh2 gbm glioblastoma gsc gscs inversely irradiation melk mitotic oncogenic phosphorylates polycomb possibility postirradiation radioresistance raise repressive serve tumorigenic turn
Tagcloud (Difference) ?		augments becomes cd31 cdkn1a cdkn2a clorgyline combines conjugate degrades dye emt goals hypoxic inactivating infrared m30 maoa micromolar modern moiety monoamine monoamines multidisciplinary neurotransmitters nfkb nmi oncogenes pca pharmacology	axis caenorhabditis catalytic coexpressed collectively contributes driven elegans evolutionarily ezh2 gbm glioblastoma gsc gscs inversely irradiation melk mitotic oncogenic phosphorylates polycomb possibility postirradiation radioresistance raise repressive serve tumorigenic turn
Tagcloud (Intersection) ?