CCNE1 and H1-1

Number of citations of the paper that reports this interaction (PubMedID 22158041)
58

Data Source:
BioGRID (affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study)

		CCNE1	H1-1
Description		cyclin E1	H1.1 linker histone, cluster member
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Cyclin E1-CDK2 Complex	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm Chromosome Cell Surface Vesicle
	Molecular Function	Protein Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding	DNA Binding Double-stranded DNA Binding Protein Binding Heparin Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Replication Initiation Protein Phosphorylation Homologous Chromosome Pairing At Meiosis Wnt Signaling Pathway Regulation Of Protein Localization Cell Division Regulation Of Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mesenchymal Stem Cell Proliferation	Nucleosome Assembly Spermatogenesis Chromosome Condensation Negative Regulation Of DNA Recombination Positive Regulation Of Receptor-mediated Endocytosis
Pathways		G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response PTK6 Regulates Cell Cycle Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) RHOBTB3 ATPase cycle	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases		Laryngeal cancer Gastric cancer
GWAS		Adult body size ( 32376654) Bladder cancer ( 20972438 24163127) Body mass index ( 25673413) Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Diastolic blood pressure ( 27841878 28135244) Medication use (diuretics) ( 31015401) Response to fenofibrate (total cholesterol levels) ( 27002377) Spatial processing ( 31596458) Walking pace ( 33128006)
Interacting Genes		71 interacting genes: AKT1 AR ARHGEF5 ARID4A ARIH1 ARNT AURKA BRCA2 BTRC CABLES1 CALM1 CCND2 CCT4 CDC25A CDC6 CDK1 CDK2 CDK3 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C COIL CUL3 FBXW7 FGFR4 FOXM1 FZR1 GLIS2 GMNC GRM1 GSK3B H1-0 H1-1 H1-5 HERC5 KAT2A KPNB1 LATS2 LINC00664 MARCKS MCM3 MRE11 MYBL2 MYC NBN NF2 PIN1 POLD1 PRC1 PRKAR1A PTPA RASSF1 RB1 RBL1 RBL2 REL RHOBTB3 RRN3 SKP2 SMARCA4 SMARCC1 SMARCD3 SPOP STK11 TERT TP73 TSC1 UBTF	54 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK11B CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L1 NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SET SMYD5 SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1
Entrez ID		898	3024
HPRD ID		00455	00820
Ensembl ID		ENSG00000105173	ENSG00000124610
Uniprot IDs		A0A0G3DHS8 P24864 V5W5X2	Q02539
PDB IDs		1W98 5L2W 7KJS 7XQK 8H4R 8H6P 8H6T 8VQ3 8VQ4	9J8O
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Nucleus Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of DNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Population Proliferation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA Metabolic Process Cyclin Binding Negative Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Cell Population Proliferation Cellular Response To Stress Cell Division Regulation Of Protein Localization To Nucleus Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Modification Process Regulation Of Signal Transduction Regulation Of Chromosome Organization Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Macromolecule Metabolic Process G2/M Transition Of Mitotic Cell Cycle	Chromatin Organization Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Chromatin Remodeling Nucleus Protein Kinase Activity Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Nucleobase-containing Compound Metabolic Process Transferase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein Phosphorylation Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Phosphorylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Cell Cycle Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Response To Stress Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Binding Positive Regulation Of Macromolecule Metabolic Process Protein Modification Process Response To Stress Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of RNA Metabolic Process ESC/E(Z) Complex Regulation Of Cell Cycle Phase Transition Cell Division Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Localization To Chromosome
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