CDC25C and YWHAH

Number of citations of the paper that reports this interaction (PMID 9278512)
268

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		CDC25C	YWHAH
Gene Name		cell division cycle 25C	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Plasma Membrane Intercalated Disc Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding WW Domain Binding	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Ion Channel Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Mitotic Nuclear Division Regulation Of Mitotic Nuclear Division Spermatogenesis Cell Proliferation Viral Process Peptidyl-tyrosine Dephosphorylation Cell Division Regulation Of Cell Cycle	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Apoptotic Process Substantia Nigra Development Glucocorticoid Receptor Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Organization Membrane Depolarization During Action Potential Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Cyclin A/B1 associated events during G2/M transition G2/M DNA damage checkpoint G2/M Checkpoints Activation of ATR in response to replication stress Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex G2/M Transition Cell Cycle Checkpoints Mitotic G2-G2/M phases Cyclin B2 mediated events Polo-like kinase mediated events Cell Cycle, Mitotic	Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions		29 interactors: BRSK1 BRSK2 CCNA2 CCNB1 CDK1 CDK2 CDS1 CHEK1 CHEK2 HRAS LCK LZTS1 MAPK1 MAPK14 MAPK3 MAPK9 MARK3 NEDD4 PCNA PIN1 PKN1 PLK1 PLK3 SRC TP53 YWHAB YWHAH YWHAQ YWHAZ	61 interactors: ABL1 ARHGEF28 BAD BCR BRAF CDC25B CDC25C CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 ING1 KCNH2 KCNK15 KCNK3 KCNK9 KIF5B KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCOA1 NCOA2 NCOA3 NEK1 NR3C1 NRIP1 PARD3 PARD6A PARD6B PARK2 PDPK1 PRKCI PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36
Entrez ID		995	7533
HPRD ID		01146	00215
Ensembl ID		ENSG00000158402	ENSG00000128245
Uniprot IDs		P30307	Q04917 Q9H4N8
PDB IDs		3BZI 3OP3	2C63 2C74
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Cell Cycle Phosphorylation Response To Stress Cell Cycle Checkpoint Apoptotic Process G2/M Transition Of Mitotic Cell Cycle Programmed Cell Death Cell Death Death Protein Phosphorylation Regulation Of Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Response To Abiotic Stimulus Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Phosphorylation Regulation Of Intracellular Transport Negative Regulation Of Mitotic Cell Cycle Ras Protein Signal Transduction Phosphate-containing Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cycle Process Cellular Response To DNA Damage Stimulus Mitotic Cell Cycle Checkpoint Regulation Of Protein Phosphorylation Cellular Response To Stimulus Positive Regulation Of Phosphorylation Mitotic Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Intrinsic Apoptotic Signaling Pathway Mitotic Cell Cycle Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Cell Aging Regulation Of Cellular Localization Regulation Of Phosphorylation Regulation Of Cellular Component Organization Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Cellular Protein Modification Process	Signaling Cell Communication Regulation Of Kinase Activity Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorus Metabolic Process System Development Multicellular Organismal Development Regulation Of Protein Phosphorylation Cellular Response To Stimulus Regulation Of Cell Death Regulation Of Protein Kinase Activity Regulation Of Cellular Process Response To Organic Substance Regulation Of Phosphorylation Regulation Of Cellular Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Response To Stimulus Intracellular Receptor Signaling Pathway Regulation Of Apoptotic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Regulation Of Metabolic Process Negative Regulation Of Protein Phosphorylation Organelle Organization Cell Cycle Negative Regulation Of Cellular Metabolic Process Response To Organonitrogen Compound Apoptotic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Programmed Cell Death Programmed Cell Death Response To Growth Factor
Tagcloud ?		acetyltransferase acetyltransferases aiding ancient assembled box caf ccaat collagen disrupted facilitating gcn5 heterodimers histocompatibility lipase nf pivotal possess r2 reductase ribonucleotide transactivation transfections ubiquitous y ya yb yc	3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization
Tagcloud (Difference) ?		acetyltransferase acetyltransferases aiding ancient assembled box caf ccaat collagen disrupted facilitating gcn5 heterodimers histocompatibility lipase nf pivotal possess r2 reductase ribonucleotide transactivation transfections ubiquitous y ya yb yc	3eta 3gamma accumulates add bipolar clumped deformed deionized eggs localizes maturation matured meiosis meiotic metaphase microinjected microtubules morpholino oligonucleotide oocyte oocytes proximity reproduction spindle spindles tubulin uninjected visualization
Tagcloud (Intersection) ?