CDC25C and MARK3

Number of citations of the paper that reports this interaction (PubMedID 12941695)
36

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		CDC25C	MARK3
Description		cell division cycle 25C	microtubule affinity regulating kinase 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrial Intermembrane Space Cytosol Nuclear Speck	Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Cell Projection Extracellular Exosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding WW Domain Binding Protein Serine/threonine Kinase Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Division Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition	Microtubule Cytoskeleton Organization Protein Phosphorylation Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Protein Localization To Nucleus
Pathways		Polo-like kinase mediated events Activation of ATR in response to replication stress RHO GTPases activate PKNs TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Cyclin A/B1/B2 associated events during G2/M transition Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Fostamatinib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Intraocular pressure ( 31959993) Normal facial asymmetry (deformation magnitude) ( 30631343) Response to radiotherapy in prostate cancer (toxicity, urinary frequency) ( 27515689) Schizophrenia ( 25056061)	Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 33020668) Cutaneous melanoma or hair colour ( 32341527) Femoral neck bone mineral density ( 22504420) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Optic disc size ( 31809533) PR interval ( 32439900) Systolic blood pressure ( 30578418 30224653) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)
Interacting Genes		37 interacting genes: BRCA1 BRSK1 BRSK2 CCNA2 CCNB1 CDK1 CDK2 CDK5 CDS1 CHEK1 CHEK2 CSNK2A1 ERBB3 ERBB4 HRAS KPNB1 LCK LMTK2 LZTS1 MAP3K5 MAPK1 MAPK14 MAPK3 MAPK9 MARK3 NEDD4 PCNA PIN1 PKN1 PLK1 PLK3 ROR2 TP53 YWHAB YWHAH YWHAQ YWHAZ	28 interacting genes: ANKRD7 ARHGEF2 ASB13 ATP6V0C CDC25C CHGB CLASP1 CPSF4 DYNLL1 FANCF FBXO7 HDAC7 KSR1 MAP2 MAPT MITF NOL11 PKP2 PMPCB PNPLA2 PRKCQ SAAL1 SFN TCEA2 TTR VPS11 YWHAG YWHAZ
Entrez ID		995	4140
HPRD ID		01146	04058
Ensembl ID		ENSG00000158402	ENSG00000075413
Uniprot IDs		B4DX61 P30307	A0A7I2V2E3 A0A7I2V2N8 A0A7I2V3B9 A0A7I2V5G3 A0A7I2V639 A0A7I2YQF7 H0YNV4 P27448 Q86U11
PDB IDs		2OJX 3BZI 3OP3 5M35 5M36 5M37	2QNJ 3FE3 7P1L 8UOH 8UOI 8UOJ 8UOK 8UOL
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Phosphorylation Intracellular Signal Transduction Phosphorylation G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Transferase Activity Signal Transduction In Response To DNA Damage ATP Binding DNA Damage Checkpoint Signaling Nucleotide Binding Cellular Response To Stress Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Cell Communication Regulation Of Signaling Mitotic Cell Cycle Phase Transition Protein Modification Process Negative Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Process Apoptotic Process Regulation Of Gene Expression Programmed Cell Death Cell Death Regulation Of Macromolecule Biosynthetic Process DNA Damage Response Protein Domain Specific Binding Regulation Of Intracellular Signal Transduction Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Phosphate-containing Compound Metabolic Process Response To Stress Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Phosphoserine Residue Binding Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle	Protein Kinase C Inhibitor Activity Phosphoserine Residue Binding Main Axon Regulation Of Microtubule Polymerization Or Depolymerization Protein Sequestering Activity Negative Regulation Of Microtubule Polymerization Or Depolymerization Protein Kinase C Binding Regulation Of Phosphorylation Positive Regulation Of Intracellular Transport Dystroglycan Binding Protein Kinase Binding Tubulin Binding Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Phototransduction, Visible Light Regulation Of Cell Differentiation Microtubule
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?