CDC25C and CDS1

Number of citations of the paper that reports this interaction (PubMedID 10681541)
0

Data Source:
BioGRID (enzymatic study)

		CDC25C	CDS1
Description		cell division cycle 25C	CDP-diacylglycerol synthase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrial Intermembrane Space Cytosol Nuclear Speck	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding WW Domain Binding Protein Serine/threonine Kinase Binding	Diacylglycerol Cholinephosphotransferase Activity Phosphatidate Cytidylyltransferase Activity Protein Binding Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Nucleotidyltransferase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Division Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition	Lipid Metabolic Process CDP-choline Pathway Phosphatidylinositol Biosynthetic Process Signal Transduction Phototransduction Phospholipid Biosynthetic Process CDP-diacylglycerol Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Lipid Droplet Formation
Pathways		Polo-like kinase mediated events Activation of ATR in response to replication stress RHO GTPases activate PKNs TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Cyclin A/B1/B2 associated events during G2/M transition Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Synthesis of PI
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Intraocular pressure ( 31959993) Normal facial asymmetry (deformation magnitude) ( 30631343) Response to radiotherapy in prostate cancer (toxicity, urinary frequency) ( 27515689) Schizophrenia ( 25056061)	Cerebral amyloid deposition (PET imaging) ( 26252872)
Interacting Genes		37 interacting genes: BRCA1 BRSK1 BRSK2 CCNA2 CCNB1 CDK1 CDK2 CDK5 CDS1 CHEK1 CHEK2 CSNK2A1 ERBB3 ERBB4 HRAS KPNB1 LCK LMTK2 LZTS1 MAP3K5 MAPK1 MAPK14 MAPK3 MAPK9 MARK3 NEDD4 PCNA PIN1 PKN1 PLK1 PLK3 ROR2 TP53 YWHAB YWHAH YWHAQ YWHAZ	7 interacting genes: CDC25C FAM209A RETREG3 SLC10A6 SLC13A4 TMEM237 UBE2J1
Entrez ID		995	1040
HPRD ID		01146	11944
Ensembl ID		ENSG00000158402	ENSG00000163624
Uniprot IDs		B4DX61 P30307	Q92903
PDB IDs		2OJX 3BZI 3OP3 5M35 5M36 5M37
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Phosphorylation Intracellular Signal Transduction Phosphorylation G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Transferase Activity Signal Transduction In Response To DNA Damage ATP Binding DNA Damage Checkpoint Signaling Nucleotide Binding Cellular Response To Stress Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Cell Communication Regulation Of Signaling Mitotic Cell Cycle Phase Transition Protein Modification Process Negative Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Process Apoptotic Process Regulation Of Gene Expression Programmed Cell Death Cell Death Regulation Of Macromolecule Biosynthetic Process DNA Damage Response Protein Domain Specific Binding Regulation Of Intracellular Signal Transduction Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Phosphate-containing Compound Metabolic Process Response To Stress Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Phosphoserine Residue Binding Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle	Sodium:sulfate Symporter Activity Symporter Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport
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