CDC25C and BRSK1

Number of citations: 0 (PubMedID 15150265)
Data Source: HPRD (in vitro, in vivo)

		CDC25C	BRSK1
Name		cell division cycle 25C	BR serine/threonine kinase 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrial Intermembrane Space Cytosol Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton Synaptic Vesicle Postsynaptic Density Cell Junction Cytoplasmic Vesicle Cell Projection Synapse Presynaptic Active Zone Cholinergic Synapse Distal Axon
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding WW Domain Binding Protein Serine/threonine Kinase Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Gamma-tubulin Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Division Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition	G2/M Transition Of Mitotic Cell Cycle Protein Phosphorylation DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Neurotransmitter Secretion Nervous System Development Axonogenesis Associative Learning Response To UV Response To Ionizing Radiation Regulation Of Synaptic Vesicle Priming Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Central Nervous System Neuron Differentiation Establishment Of Cell Polarity Neuron Differentiation Regulation Of Synaptic Plasticity Neuron Projection Morphogenesis Regulation Of Axonogenesis Centrosome Duplication Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Synaptic Vesicle Cycle Regulation Of Synaptic Vesicle Clustering
Pathways		Polo-like kinase mediated events Activation of ATR in response to replication stress RHO GTPases activate PKNs TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Cyclin A/B1/B2 associated events during G2/M transition Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	None
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Intraocular pressure ( 31959993 ) Normal facial asymmetry (deformation magnitude) ( 30631343 ) Response to radiotherapy in prostate cancer (toxicity, urinary frequency) ( 27515689 ) Schizophrenia ( 25056061 )	Low hand grip strength (60 years and older) (EWGSOP) ( 33510174 ) Menarche and menopause (age at onset) ( 19448621 ) Menopause (age at onset) ( 19448619 26414677 )
Novel Interactors		None recorded	1 novel interactors: DNAAF3
Interacting Genes		37 interacting genes: BRCA1 BRSK1 BRSK2 CCNA2 CCNB1 CDK1 CDK2 CDK5 CDS1 CHEK1 CHEK2 CSNK2A1 ERBB3 ERBB4 HRAS KPNB1 LCK LMTK2 LZTS1 MAP3K5 MAPK1 MAPK14 MAPK3 MAPK9 MARK3 NEDD4 PCNA PIN1 PKN1 PLK1 PLK3 ROR2 TP53 YWHAB YWHAH YWHAQ YWHAZ	8 interacting genes: BRCA1 CDC25B CDC25C HSD17B7 HSPA1A MAPT PAK1 WEE1
Entrez ID		995	84446
HPRD ID		01146	12533
Ensembl ID		ENSG00000158402	ENSG00000160469
Uniprot IDs		B4DX61 P30307	Q8TDC3
PDB IDs		2OJX 3BZI 3OP3 5M35 5M36 5M37	Not available
GO Terms Enriched among Interactors		Protein Kinase Activity Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Phosphorylation Intracellular Signal Transduction Phosphorylation G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Transferase Activity Signal Transduction In Response To DNA Damage ATP Binding DNA Damage Checkpoint Signaling Nucleotide Binding Cellular Response To Stress Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Cell Communication Regulation Of Signaling Mitotic Cell Cycle Phase Transition Protein Modification Process Negative Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Process Apoptotic Process Regulation Of Gene Expression Programmed Cell Death Cell Death Regulation Of Macromolecule Biosynthetic Process DNA Damage Response Protein Domain Specific Binding Regulation Of Intracellular Signal Transduction Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Phosphate-containing Compound Metabolic Process Response To Stress Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Phosphoserine Residue Binding Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle	Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Regulation Of Microtubule Polymerization Regulation Of G2/MI Transition Of Meiotic Cell Cycle Regulation Of Microtubule-based Process Positive Regulation Of Microtubule Nucleation Positive Regulation Of Protein Polymerization Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Growth Positive Regulation Of Mitotic Cell Cycle Regulation Of Microtubule Nucleation Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Protein Kinase Binding Cell Cycle Phase Transition Positive Regulation Of Meiotic Cell Cycle Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Cell Growth Positive Regulation Of Supramolecular Fiber Organization Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Regulation Of Growth Regulation Of Organelle Organization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Growth Positive Regulation Of Axon Extension Positive Regulation Of Cell Cycle Process Cellular Response To Heat Tubulin Binding Microtubule-based Process Regulation Of Meiotic Cell Cycle Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Positive Regulation Of Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Organelle Organization