WDR1 and HSPB2

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		WDR1	HSPB2
Description		WD repeat domain 1	heat shock protein family B (small) member 2
Image		No pdb structure
GO Annotations	Cellular Component	Podosome Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Actin Cytoskeleton Cell Junction Cortical Actin Cytoskeleton Cell Projection Synapse Extracellular Exosome Anchoring Junction Glutamatergic Synapse	Nucleus Cytoplasm Cytosol
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding
	Biological Process	Neutrophil Mediated Immunity Sensory Perception Of Sound Regulation Of Cell Shape Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Platelet Formation Regulation Of Actin Filament Depolymerization Positive Regulation Of Actin Filament Depolymerization Cortical Cytoskeleton Organization Locomotion Establishment Of Planar Polarity Of Follicular Epithelium Apical Junction Assembly Maintenance Of Epithelial Cell Apical/basal Polarity Sarcomere Organization Regulation Of Oligodendrocyte Differentiation Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Neutrophil Migration	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process
Pathways		Platelet degranulation
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Cardiovascular disease risk factors ( 21943158) Cleft plate (environmental tobacco smoke interaction) ( 24516586) Estimated glomerular filtration rate ( 31152163) Gout ( 33832965) Pulse pressure ( 30224653) Schizophrenia (age at onset) ( 21688384) Serum uric acid levels ( 32514006) Urate levels ( 18179892 31578528) Uric acid levels ( 22229870)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: CARD11 CFL1 CSNK2B GRB2 HSPB2 SKIC2	108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335
Entrez ID		9948	3316
HPRD ID		09199	03712
Ensembl ID		ENSG00000071127	ENSG00000170276
Uniprot IDs		A0A8V8TP22 O75083 V9HWG7	A8KAH6 Q16082
PDB IDs			6F2R
Enriched GO Terms of Interacting Partners?		Cofilin-actin Rod Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Tissue Morphogenesis Positive Regulation Of Barbed-end Actin Filament Capping Morphogenesis Of An Epithelium Positive Regulation Of Protein Localization To Cell Leading Edge Guanyl-nucleotide Exchange Factor Adaptor Activity T Cell Costimulation Positive Regulation Of Cell Adhesion Protein Phosphatase Binding Negative Regulation Of Postsynaptic Density Organization Grb2-EGFR Complex Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Protein Localization To Cell Leading Edge Cytosol Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Ski Complex Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Neural Fold Formation Actin Filament Fragmentation Somatic Muscle Development Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Dendritic Spine Maintenance Regulation Of Barbed-end Actin Filament Capping Release From Viral Latency CBM Complex Regulation Of Cell Adhesion Cell-cell Junction Negative Regulation Of Lamellipodium Assembly Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Neurotrophin TRKA Receptor Binding Intracellular Signaling Cassette Protein-macromolecule Adaptor Activity Extracellular Exosome Protein Domain Specific Binding 3'-5' RNA Helicase Activity Adiponectin-activated Signaling Pathway Negative Regulation Of Cell Size Regulation Of Cellular Component Size GMP Kinase Activity CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Synaptic Plasticity Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction	Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?