WDR1

Description		WD repeat domain 1
Image		No pdb structure
GO Annotations	Cellular Component	Podosome Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Actin Cytoskeleton Cell Junction Cortical Actin Cytoskeleton Cell Projection Synapse Extracellular Exosome Anchoring Junction Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Neutrophil Mediated Immunity Sensory Perception Of Sound Regulation Of Cell Shape Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Platelet Formation Regulation Of Actin Filament Depolymerization Positive Regulation Of Actin Filament Depolymerization Cortical Cytoskeleton Organization Locomotion Establishment Of Planar Polarity Of Follicular Epithelium Apical Junction Assembly Maintenance Of Epithelial Cell Apical/basal Polarity Sarcomere Organization Regulation Of Oligodendrocyte Differentiation Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Neutrophil Migration
Pathways		Platelet degranulation
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Cardiovascular disease risk factors ( 21943158) Cleft plate (environmental tobacco smoke interaction) ( 24516586) Estimated glomerular filtration rate ( 31152163) Gout ( 33832965) Pulse pressure ( 30224653) Schizophrenia (age at onset) ( 21688384) Serum uric acid levels ( 32514006) Urate levels ( 18179892 31578528) Uric acid levels ( 22229870)
Interacting Genes		6 interacting genes: CARD11 CFL1 CSNK2B GRB2 HSPB2 SKIC2
Entrez ID		9948
HPRD ID		09199
Ensembl ID		ENSG00000071127
Uniprot IDs		A0A8V8TP22 O75083 V9HWG7
PDB IDs
Enriched GO Terms of Interacting Partners?		Cofilin-actin Rod Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Tissue Morphogenesis Positive Regulation Of Barbed-end Actin Filament Capping Morphogenesis Of An Epithelium Positive Regulation Of Protein Localization To Cell Leading Edge Guanyl-nucleotide Exchange Factor Adaptor Activity T Cell Costimulation Positive Regulation Of Cell Adhesion Protein Phosphatase Binding Negative Regulation Of Postsynaptic Density Organization Grb2-EGFR Complex Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Protein Localization To Cell Leading Edge Cytosol Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Ski Complex Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Neural Fold Formation Actin Filament Fragmentation Somatic Muscle Development Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Dendritic Spine Maintenance Regulation Of Barbed-end Actin Filament Capping Release From Viral Latency CBM Complex Regulation Of Cell Adhesion Cell-cell Junction Negative Regulation Of Lamellipodium Assembly Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Neurotrophin TRKA Receptor Binding Intracellular Signaling Cassette Protein-macromolecule Adaptor Activity Extracellular Exosome Protein Domain Specific Binding 3'-5' RNA Helicase Activity Adiponectin-activated Signaling Pathway Negative Regulation Of Cell Size Regulation Of Cellular Component Size GMP Kinase Activity CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Synaptic Plasticity Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction
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