WDR1 and CFL1

Number of citations of the paper that reports this interaction (PMID 10366597)
53

Data Source:
HPRD (two hybrid, in vitro)

		WDR1	CFL1
Gene Name		WD repeat domain 1	cofilin 1 (non-muscle)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Podosome Extracellular Region Cytoplasm Cytosol Actin Filament Cell Junction Cell Projection Extracellular Vesicular Exosome	Extracellular Space Nucleus Cytoplasm Cell-cell Junction Focal Adhesion Membrane Nuclear Matrix Cortical Actin Cytoskeleton Lamellipodium Membrane Vesicle Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	Actin Binding	Actin Binding Protein Binding
	Biological Process	Platelet Degranulation Blood Coagulation Sensory Perception Of Sound Platelet Activation Regulation Of Oligodendrocyte Differentiation	Mitotic Cytokinesis Neural Crest Cell Migration Neural Fold Formation Platelet Degranulation Protein Phosphorylation Protein Import Into Nucleus Cytoskeleton Organization Rho Protein Signal Transduction Axon Guidance Blood Coagulation Response To Virus Regulation Of Cell Morphogenesis Establishment Of Cell Polarity Actin Cytoskeleton Organization Actin Filament Depolymerization Platelet Activation Positive Regulation Of Actin Filament Depolymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Apoptotic Process Response To Amino Acid Innate Immune Response Negative Regulation Of Cell Size Ephrin Receptor Signaling Pathway Regulation Of Dendritic Spine Morphogenesis
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation	Axon guidance Semaphorin interactions Platelet degranulation EPHB-mediated forward signaling Response to elevated platelet cytosolic Ca2+ Sema3A PAK dependent Axon repulsion EPH-Ephrin signaling Platelet activation, signaling and aggregation Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Cardiovascular disease risk factors ( 21943158) Urate levels ( 18179892) Uric acid levels ( 21294900 22229870)	Breast cancer ( 23535729) DNA methylation (variation) ( 23725790)
Protein-Protein Interactions		5 interactors: CARD11 CFL1 CSNK2B GRB2 SKIV2L	37 interactors: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CFL2 CLCN5 EGFR HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP NRK POT1 PSEN1 RAD21 RPS6KA1 SLC2A4 SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 UCHL5 WDR1 YWHAG YWHAQ YWHAZ
Entrez ID		9948	1072
HPRD ID		09199	03261
Ensembl ID		ENSG00000071127	ENSG00000172757
Uniprot IDs		O75083	P23528
PDB IDs			1Q8G 1Q8X 3J0S 4BEX
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Immune Response-regulating Signaling Pathway Morphogenesis Of An Epithelium T Cell Costimulation Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Positive Regulation Of Immune Response Neuron Projection Morphogenesis Tissue Morphogenesis Cell Activation Cell Morphogenesis Involved In Differentiation Innate Immune Response Neuron Projection Development Cell Projection Morphogenesis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Part Morphogenesis Regulation Of Immune Response Positive Regulation Of Immune System Process Neuron Development Platelet Activation Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Ras Protein Signal Transduction Cell Morphogenesis Epithelium Development Fc-epsilon Receptor Signaling Pathway Neuron Differentiation Positive Regulation Of Cell-cell Adhesion Cell Projection Organization Phagocytosis Locomotion Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of T Cell Activation Immune Response Regulation Of Immune System Process Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Cell Activation Defense Response Adiponectin-activated Signaling Pathway	Generation Of Neurons Neurogenesis Developmental Process Nervous System Development System Development Multicellular Organismal Development Phosphate-containing Compound Metabolic Process Regulation Of Organelle Organization Cell Differentiation Positive Regulation Of Organelle Organization Anatomical Structure Development Actin Cytoskeleton Organization Cellular Component Assembly Actin Filament-based Process Immune Response-regulating Signaling Pathway Platelet Activation Actomyosin Structure Organization Regulation Of Neurogenesis Anatomical Structure Morphogenesis MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Neuron Differentiation Cell Development Response To Stimulus Axon Guidance Phosphorylation Negative Regulation Of Catalytic Activity Cell Morphogenesis Involved In Neuron Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cellular Component Organization Fc Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Stress Homeostatic Process Regulation Of Axonogenesis Regulation Of Cell Development Signal Transduction By Phosphorylation Neuron Projection Morphogenesis Organelle Organization Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Myofibril Assembly Cell Activation Regulation Of Lamellipodium Assembly Regulation Of Cell Projection Organization Neuron Development Adherens Junction Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Apoptotic Process
Tagcloud ?		actb actr3 anxa2 anxa6 canine cope dedifferentiation grade histologically hspa9 interesting kit mast mct mcts mutational noteworthy observable oncology paradox pdia3 proliferating proteome reflected tcp1a tcp1e transferrin tryptase tumours	anxa4 cacybp ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 tpd52l2 trio ube2m ywhag
Tagcloud (Difference) ?		actb actr3 anxa2 anxa6 canine cope dedifferentiation grade histologically hspa9 interesting kit mast mct mcts mutational noteworthy observable oncology paradox pdia3 proliferating proteome reflected tcp1a tcp1e transferrin tryptase tumours	anxa4 cacybp ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 tpd52l2 trio ube2m ywhag
Tagcloud (Intersection) ?