IPO11 and KEAP1

Number of citations of the paper that reports this interaction (PMID 21383067)
9

Data Source:
BioGRID (pull down)

		IPO11	KEAP1
Gene Name		importin 11	kelch-like ECH-associated protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm Cytoplasm Endoplasmic Reticulum Microtubule Organizing Center Cytosol Midbody Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Ran GTPase Binding Protein Transporter Activity	Protein Binding Transcription Factor Binding
	Biological Process	Ribosomal Protein Import Into Nucleus	In Utero Embryonic Development Transcription, DNA-templated Proteasomal Ubiquitin-independent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Alcohol and nictotine co-dependence ( 23216389)
Protein-Protein Interactions		11 interactors: C1orf94 EIF4A2 KEAP1 NXF1 PLCD4 RAN RPL12 TRAF2 UBE2E1 UBE2E2 UBE2E3	38 interactors: AK4 AMER1 ATG5 BAD BPTF CAT CCNB1IP1 CLU DPP3 ETF1 FAM117B FAM46A GLRX5 GYPA IPO11 IRF1 KLHL3 KPNA6 LSM3 MAD2L1 MAPKBP1 MYO7A NFE2L2 NUDT4 OXR1 PDCD6IP PIDD1 PRKAG1 PRKCE PTMA RECK RELA SNRPN SQSTM1 TERF1 TSC22D4 WDR83 ZSCAN32
Entrez ID		51194	9817
HPRD ID		10003	12079
Ensembl ID		ENSG00000086200	ENSG00000079999
Uniprot IDs		Q9UI26	Q14145
PDB IDs			1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4IN4 4IQK
Enriched GO Terms of Interacting Partners?		Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation ISG15-protein Conjugation Catabolic Process Protein K11-linked Ubiquitination Viral Process Cellular Response To Cytokine Stimulus Response To Cytokine Positive Regulation Of Proteolysis Cellular Macromolecule Catabolic Process Positive Regulation Of Protein Binding Negative Regulation Of RNA-directed RNA Polymerase Activity Cellular Protein Metabolic Process Cytokine-mediated Signaling Pathway Nuclear Export Positive Regulation Of Binding Ribosomal Small Subunit Export From Nucleus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Proteasomal Ubiquitin-independent Protein Catabolic Process Regulation Of Protein Binding Nuclear-transcribed MRNA Catabolic Process Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process MRNA Catabolic Process Protein Metabolic Process Regulation Of Proteolysis Cytoplasmic Transport RNA Catabolic Process Negative Regulation Of Glial Cell Apoptotic Process Viral Life Cycle Cellular Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Ribosomal Large Subunit Export From Nucleus Histone H2B Ubiquitination Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Ribosomal Subunit Export From Nucleus Poly(A)+ MRNA Export From Nucleus Regulation Of Cell Cycle Phase Transition Translational Initiation Positive Regulation Of Protein Homodimerization Activity Metabolic Process Cellular Response To Nitric Oxide Nucleocytoplasmic Transport Proteasomal Protein Catabolic Process Regulation Of Binding	Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Virus Positive Regulation Of Interleukin-12 Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Cellular Response To Nicotine Apoptotic Process Response To Other Organism Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Programmed Cell Death Response To Biotic Stimulus Cell Death Death Regulation Of Interleukin-12 Biosynthetic Process ADP Metabolic Process Response To Reactive Oxygen Species Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Mucus Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Response To Oxidative Stress Regulation Of Mucus Secretion Regulation Of Proteolysis Negative Regulation Of Cell Cycle Regulation Of Cell Division Regulation Of Type I Interferon Production Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Response To Hydrogen Peroxide Response To Drug Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Macrophage Activation Metabolic Process Regulation Of Wound Healing
Tagcloud ?			acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg
Tagcloud (Difference) ?			acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg
Tagcloud (Intersection) ?