CD81 and ITGA4

Number of citations of the paper that reports this interaction (PubMedID 10229664)
38

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CD81	ITGA4
Description		CD81 molecule	integrin subunit alpha 4
Image
GO Annotations	Cellular Component	Immunological Synapse Cytosol Plasma Membrane Focal Adhesion Basal Plasma Membrane Membrane Basolateral Plasma Membrane Vesicle Extracellular Exosome Tetraspanin-enriched Microdomain	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Growth Cone Integrin Alpha4-beta1 Complex Integrin Alpha4-beta7 Complex Neuronal Cell Body Extracellular Exosome
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding Lipid Binding Cholesterol Binding MHC Class II Protein Complex Binding MHC Class II Protein Binding Transferrin Receptor Binding	Fibronectin Binding Antigen Binding Integrin Binding Protein Binding Coreceptor Activity C-X3-C Chemokine Binding Signaling Receptor Activity Metal Ion Binding Cell Adhesion Molecule Binding Protein Antigen Binding
	Biological Process	Immunological Synapse Formation Adaptive Immune Response Immune System Process Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Inflammatory Response To Antigenic Stimulus Myoblast Fusion Involved In Skeletal Muscle Regeneration Positive Regulation Of B Cell Proliferation Receptor Internalization Regulation Of Protein Stability Macrophage Fusion CD4-positive, Alpha-beta T Cell Costimulation Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation Protein Localization To Lysosome Positive Regulation Of Protein Exit From Endoplasmic Reticulum Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Localization To Plasma Membrane Osteoclast Fusion Positive Regulation Of Receptor Clustering Positive Regulation Of Protein Catabolic Process In The Vacuole Regulation Of Macrophage Migration Positive Regulation Of Adaptive Immune Memory Response Regulation Of Cell Motility Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell	Immune Response In Gut-associated Lymphoid Tissue Positive Regulation Of Leukocyte Migration Cell-matrix Adhesion Involved In Ameboidal Cell Migration Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Tissue Development B Cell Differentiation Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Receptor Clustering Negative Regulation Of Vasoconstriction Embryonic Morphogenesis Leukocyte Migration Leukocyte Tethering Or Rolling Diapedesis Axonogenesis Involved In Innervation Cellular Response To Cytokine Stimulus Negative Regulation Of Protein Homodimerization Activity Cell-cell Adhesion Import Into Cell Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Leukocyte Tethering Or Rolling Cellular Response To Amyloid-beta Positive Regulation Of Vascular Endothelial Cell Proliferation Neuron Projection Extension Clathrin-dependent Extracellular Exosome Endocytosis Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T Cell Migration
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Regulation of Complement cascade	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions RUNX3 Regulates Immune Response and Cell Migration Potential therapeutics for SARS
Drugs			Natalizumab ATL1102 CDP323 R1295 R411 Tinzaparin Vedolizumab MK-0668
Diseases
GWAS		Malaria ( 31844061)	Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 20190752 22057235) Crohn's disease ( 28067908) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Inflammatory bowel disease ( 28067908) Lymphocyte percentage of white cells ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Monocyte count ( 23314186 32888494 29403010 28193307 27863252 25096241) Monocyte percentage of white cells ( 27863252 32888494) Monocyte-lymphocyte ratio ( 28193307) Multiple sclerosis ( 24076602) Neurofibrillary tangles ( 25188341) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum alkaline phosphatase levels ( 33547301) Sweet taste preference ( 32572145) Ulcerative colitis ( 28067908) White blood cell count ( 29403010 21738480 32888494) White blood cell count (basophil) ( 29403010) White blood cell count (monocyte) ( 28158719) White blood cell types ( 21738478)
Interacting Genes		62 interacting genes: ADRA1A ADRB2 AQP6 BDKRB2 BST2 CCR2 CCR9 CD19 CD79A CD9 CHRM4 CPLX4 CSNK2B DLG5 EBP ERGIC3 F2RL1 FAM209A FKBP7 GJA4 GLP1R GORAB GPR152 GPR35 GPX8 HNRNPD HRH1 HTR4 IFITM1 IGSF8 INO80B ITGA4 JAK3 KIT LBR LHFPL5 LMNA MC4R MCEE MRPS18B MYCBP2 MYOC NEMP1 OXTR PDZK1IP1 PTGFRN RBBP6 RNF128 SAR1A SDHAF4 SHC1 SIRPA SLC18A1 SLC26A6 STX1A THAP4 TMX2 TREX1 TSHR TSPAN4 VKORC1 ZBTB16	16 interacting genes: ADAM28 CD81 CD82 EED FN1 ICAM4 ITGB1 ITGB7 LGALS8 LPXN MADCAM1 PRKACA PRKAR1A PXN TGFB1I1 VCAN
Entrez ID		975	3676
HPRD ID		08924	01894
Ensembl ID		ENSG00000110651	ENSG00000115232
Uniprot IDs		A6NMH8 E9PJK1 H0YEE2 P60033	P13612
PDB IDs		1G8Q 1IV5 3X0E 5DFV 5DFW 5M2C 5M33 5M3D 5M3T 5M4R 5TCX 6EJG 6EJM 6EK2 6U9S 7JIC	3V4P 3V4V 4HKC 5C7Z 5FPI
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity Membrane G Protein-coupled Receptor Signaling Pathway Plasma Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Tube Size System Process Regulation Of Multicellular Organismal Process Regulation Of Vasoconstriction Regulation Of System Process Negative Regulation Of Dendritic Cell Cytokine Production Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Circulatory System Process Regulation Of Locomotion Regulation Of Dendritic Cell Cytokine Production Myoblast Fusion Involved In Skeletal Muscle Regeneration G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Vascular Process In Circulatory System Cell Surface Receptor Signaling Pathway B Cell Differentiation B Cell Activation Leukocyte Differentiation Chemokine Receptor Activity Developmental Process Regulation Of Production Of Molecular Mediator Of Immune Response Secretion Regulation Of Cytokine Production Involved In Immune Response Cell Activation Cytokine-mediated Signaling Pathway Response To Psychosocial Stress Monocyte Extravasation Positive Regulation Of Vasoconstriction Regulation Of Cell Migration Mononuclear Cell Differentiation Leukocyte Activation Negative Regulation Of Viral Life Cycle Negative Regulation Of Multicellular Organismal Process Lymphocyte Activation Response To Interferon-beta Regulation Of Cell Motility Lymphocyte Differentiation Regulation Of Blood Circulation Regulation Of Blood Pressure Adrenergic Receptor Activity Protein Antigen Binding Ossification Involved In Bone Maturation Positive Regulation Of Cold-induced Thermogenesis	Integrin Binding Cell-substrate Adhesion Endothelial Cell Migration Cell Adhesion Substrate Adhesion-dependent Cell Spreading Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Focal Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Heterotypic Cell-cell Adhesion Cell Migration Integrin Binding Involved In Cell-matrix Adhesion Leukocyte Cell-cell Adhesion Cell Motility CAMP-dependent Protein Kinase Complex Cellular Response To Glucagon Stimulus Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Virus Receptor Activity Plasma Membrane Transforming Growth Factor Beta Receptor Signaling Pathway Response To Glucagon Symbiont Entry Into Host Cell Cell Surface Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Integrin Complex Myoblast Fusion Cell Adhesion Mediated By Integrin Response To Muscle Activity Cellular Response To Low-density Lipoprotein Particle Stimulus Biological Process Involved In Interaction With Host Anchoring Junction Plasma Membrane Raft Cell-cell Fusion Syncytium Formation By Plasma Membrane Fusion Cellular Response To Lipoprotein Particle Stimulus Syncytium Formation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Protein Localization Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Sarcomere Organization Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Ciliary Base T Cell Costimulation Immunological Synapse Mesoderm Formation Macrophage Fusion
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