CD81 and SDHAF4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CD81	SDHAF4
Description		CD81 molecule	succinate dehydrogenase complex assembly factor 4
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GO Annotations	Cellular Component	Immunological Synapse Cytosol Plasma Membrane Focal Adhesion Basal Plasma Membrane Membrane Basolateral Plasma Membrane Vesicle Extracellular Exosome Tetraspanin-enriched Microdomain	Mitochondrion Mitochondrial Matrix
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding Lipid Binding Cholesterol Binding MHC Class II Protein Complex Binding MHC Class II Protein Binding Transferrin Receptor Binding	Protein Binding Enzyme Activator Activity Protein Folding Chaperone
	Biological Process	Immunological Synapse Formation Adaptive Immune Response Immune System Process Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Inflammatory Response To Antigenic Stimulus Myoblast Fusion Involved In Skeletal Muscle Regeneration Positive Regulation Of B Cell Proliferation Receptor Internalization Regulation Of Protein Stability Macrophage Fusion CD4-positive, Alpha-beta T Cell Costimulation Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation Protein Localization To Lysosome Positive Regulation Of Protein Exit From Endoplasmic Reticulum Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Localization To Plasma Membrane Osteoclast Fusion Positive Regulation Of Receptor Clustering Positive Regulation Of Protein Catabolic Process In The Vacuole Regulation Of Macrophage Migration Positive Regulation Of Adaptive Immune Memory Response Regulation Of Cell Motility Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell	Tricarboxylic Acid Cycle Protein Folding Mitochondrial Respiratory Chain Complex II Assembly Innate Immune Response Cellular Respiration
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Regulation of Complement cascade	Maturation of TCA enzymes and regulation of TCA cycle
Drugs
Diseases
GWAS		Malaria ( 31844061)
Interacting Genes		62 interacting genes: ADRA1A ADRB2 AQP6 BDKRB2 BST2 CCR2 CCR9 CD19 CD79A CD9 CHRM4 CPLX4 CSNK2B DLG5 EBP ERGIC3 F2RL1 FAM209A FKBP7 GJA4 GLP1R GORAB GPR152 GPR35 GPX8 HNRNPD HRH1 HTR4 IFITM1 IGSF8 INO80B ITGA4 JAK3 KIT LBR LHFPL5 LMNA MC4R MCEE MRPS18B MYCBP2 MYOC NEMP1 OXTR PDZK1IP1 PTGFRN RBBP6 RNF128 SAR1A SDHAF4 SHC1 SIRPA SLC18A1 SLC26A6 STX1A THAP4 TMX2 TREX1 TSHR TSPAN4 VKORC1 ZBTB16	3 interacting genes: CD81 CYB5B UPK1B
Entrez ID		975	135154
HPRD ID		08924	12888
Ensembl ID		ENSG00000110651	ENSG00000154079
Uniprot IDs		A6NMH8 E9PJK1 H0YEE2 P60033	Q5VUM1
PDB IDs		1G8Q 1IV5 3X0E 5DFV 5DFW 5M2C 5M33 5M3D 5M3T 5M4R 5TCX 6EJG 6EJM 6EK2 6U9S 7JIC	8DYD 8DYE
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity Membrane G Protein-coupled Receptor Signaling Pathway Plasma Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Tube Size System Process Regulation Of Multicellular Organismal Process Regulation Of Vasoconstriction Regulation Of System Process Negative Regulation Of Dendritic Cell Cytokine Production Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Circulatory System Process Regulation Of Locomotion Regulation Of Dendritic Cell Cytokine Production Myoblast Fusion Involved In Skeletal Muscle Regeneration G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Vascular Process In Circulatory System Cell Surface Receptor Signaling Pathway B Cell Differentiation B Cell Activation Leukocyte Differentiation Chemokine Receptor Activity Developmental Process Regulation Of Production Of Molecular Mediator Of Immune Response Secretion Regulation Of Cytokine Production Involved In Immune Response Cell Activation Cytokine-mediated Signaling Pathway Response To Psychosocial Stress Monocyte Extravasation Positive Regulation Of Vasoconstriction Regulation Of Cell Migration Mononuclear Cell Differentiation Leukocyte Activation Negative Regulation Of Viral Life Cycle Negative Regulation Of Multicellular Organismal Process Lymphocyte Activation Response To Interferon-beta Regulation Of Cell Motility Lymphocyte Differentiation Regulation Of Blood Circulation Regulation Of Blood Pressure Adrenergic Receptor Activity Protein Antigen Binding Ossification Involved In Bone Maturation Positive Regulation Of Cold-induced Thermogenesis	Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Myoblast Fusion Involved In Skeletal Muscle Regeneration Apical Plasma Membrane Urothelial Plaque Nitric-oxide Synthase Complex MHC Class II Protein Binding Humoral Immune Response Mediated By Circulating Immunoglobulin Osteoclast Fusion Nitrite Reductase (NO-forming) Activity Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Tetraspanin-enriched Microdomain Positive Regulation Of Protein Exit From Endoplasmic Reticulum Transferrin Receptor Binding Positive Regulation Of Receptor Clustering Positive Regulation Of Inflammatory Response To Antigenic Stimulus Immunological Synapse Formation Regulation Of Receptor Clustering Positive Regulation Of Type 2 Immune Response Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Regulation Of Protein Exit From Endoplasmic Reticulum Nitric Oxide Biosynthetic Process Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation MHC Class II Protein Complex Binding Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Myoblast Fusion Positive Regulation Of T Cell Cytokine Production Cellular Response To Low-density Lipoprotein Particle Stimulus Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Regulation Of Type 2 Immune Response Cell-cell Fusion Syncytium Formation By Plasma Membrane Fusion Cellular Response To Lipoprotein Particle Stimulus Syncytium Formation Immunoglobulin Mediated Immune Response Regulation Of T Cell Cytokine Production T Cell Costimulation B Cell Mediated Immunity Immunological Synapse Positive Regulation Of B Cell Proliferation Regulation Of Macrophage Migration Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Cholesterol Binding
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