CD81 and BST2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CD81	BST2
Name		CD81 molecule	bone marrow stromal cell antigen 2
Structure
GO Annotations	Cellular Component	Immunological Synapse Cytosol Plasma Membrane Focal Adhesion Basal Plasma Membrane Membrane Basolateral Plasma Membrane Vesicle Extracellular Exosome Tetraspanin-enriched Microdomain	Cytoplasm Endosome Late Endosome Multivesicular Body Golgi Apparatus Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Azurophil Granule Membrane Membrane Raft Extracellular Exosome Side Of Membrane
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding Lipid Binding Cholesterol Binding MHC Class II Protein Complex Binding MHC Class II Protein Binding Transferrin Receptor Binding	RNA Binding Protein Binding Metalloendopeptidase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Immunological Synapse Formation Adaptive Immune Response Immune System Process Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Inflammatory Response To Antigenic Stimulus Myoblast Fusion Involved In Skeletal Muscle Regeneration Positive Regulation Of B Cell Proliferation Receptor Internalization Regulation Of Protein Stability Macrophage Fusion CD4-positive, Alpha-beta T Cell Costimulation Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation Protein Localization To Lysosome Positive Regulation Of Protein Exit From Endoplasmic Reticulum Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Localization To Plasma Membrane Osteoclast Fusion Positive Regulation Of Receptor Clustering Positive Regulation Of Protein Catabolic Process In The Vacuole Regulation Of Macrophage Migration Positive Regulation Of Adaptive Immune Memory Response Regulation Of Cell Motility Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell	Immune System Process Negative Regulation Of Plasmacytoid Dendritic Cell Cytokine Production Response To Virus Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Response To Type II Interferon Response To Interferon-alpha Response To Interferon-beta B Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Positive Regulation Of Leukocyte Proliferation Negative Regulation Of Intracellular Transport Of Viral Material
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Regulation of Complement cascade	Neutrophil degranulation Interferon alpha/beta signaling SARS-CoV-1 activates/modulates innate immune responses
GWAS		Malaria ( 31844061 )	No GWAS studies recorded
Interacting Genes		62 interacting genes: ADRA1A ADRB2 AQP6 BDKRB2 BST2 CCR2 CCR9 CD19 CD79A CD9 CHRM4 CPLX4 CSNK2B DLG5 EBP ERGIC3 F2RL1 FAM209A FKBP7 GJA4 GLP1R GORAB GPR152 GPR35 GPX8 HNRNPD HRH1 HTR4 IFITM1 IGSF8 INO80B ITGA4 JAK3 KIT LBR LHFPL5 LMNA MC4R MCEE MRPS18B MYCBP2 MYOC NEMP1 OXTR PDZK1IP1 PTGFRN RBBP6 RNF128 SAR1A SDHAF4 SHC1 SIRPA SLC18A1 SLC26A6 STX1A THAP4 TMX2 TREX1 TSHR TSPAN4 VKORC1 ZBTB16	3 interacting genes: CD81 HAGH HARS2
Entrez ID		975	684
HPRD ID		08924	02759
Ensembl ID		ENSG00000110651	ENSG00000130303
Uniprot IDs		A6NMH8 E9PJK1 H0YEE2 P60033	A0A024R7H5 Q10589
PDB IDs		1G8Q 1IV5 3X0E 5DFV 5DFW 5M2C 5M33 5M3D 5M3T 5M4R 5TCX 6EJG 6EJM 6EK2 6U9S 7JIC	2LK9 2X7A 2XG7 3MQ7 3MQ9 3MQB 3MQC 3NWH 4P6Z 6CM9 6CRI 6D83 6D84 6DFF 7Q9A
GO Terms Enriched among Interactors		G Protein-coupled Receptor Activity Membrane G Protein-coupled Receptor Signaling Pathway Plasma Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Tube Size System Process Regulation Of Multicellular Organismal Process Regulation Of Vasoconstriction Regulation Of System Process Negative Regulation Of Dendritic Cell Cytokine Production Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Circulatory System Process Regulation Of Locomotion Regulation Of Dendritic Cell Cytokine Production Myoblast Fusion Involved In Skeletal Muscle Regeneration G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Vascular Process In Circulatory System Cell Surface Receptor Signaling Pathway B Cell Differentiation B Cell Activation Leukocyte Differentiation Chemokine Receptor Activity Developmental Process Regulation Of Production Of Molecular Mediator Of Immune Response Secretion Regulation Of Cytokine Production Involved In Immune Response Cell Activation Cytokine-mediated Signaling Pathway Response To Psychosocial Stress Monocyte Extravasation Positive Regulation Of Vasoconstriction Regulation Of Cell Migration Mononuclear Cell Differentiation Leukocyte Activation Negative Regulation Of Viral Life Cycle Negative Regulation Of Multicellular Organismal Process Lymphocyte Activation Response To Interferon-beta Regulation Of Cell Motility Lymphocyte Differentiation Regulation Of Blood Circulation Regulation Of Blood Pressure Adrenergic Receptor Activity Protein Antigen Binding Ossification Involved In Bone Maturation Positive Regulation Of Cold-induced Thermogenesis	Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Myoblast Fusion Involved In Skeletal Muscle Regeneration Hydroxyacylglutathione Hydrolase Activity Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione Negative Regulation Of Female Gonad Development Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Negative Regulation Of Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Histidine-tRNA Ligase Activity Histidyl-tRNA Aminoacylation Methylglyoxal Catabolic Process To Lactate Cellular Detoxification Of Methylglyoxal Hemi-methylated DNA-binding Metanephric S-shaped Body Morphogenesis MHC Class II Protein Binding Humoral Immune Response Mediated By Circulating Immunoglobulin Osteoclast Fusion Methylglyoxal Metabolic Process Negative Regulation Of Cell Proliferation Involved In Kidney Development Thorax And Anterior Abdomen Determination S-shaped Body Morphogenesis Double-stranded Methylated DNA Binding Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process In The Vacuole Diaphragm Development Regulation Of Female Gonad Development Positive Regulation Of Male Gonad Development Cardiac Muscle Cell Fate Commitment Metanephric Mesenchyme Development Positive Regulation Of T-helper 2 Cell Cytokine Production Tetraspanin-enriched Microdomain Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Protein Exit From Endoplasmic Reticulum Transferrin Receptor Binding Immunological Synapse Formation Positive Regulation Of Receptor Clustering Positive Regulation Of Inflammatory Response To Antigenic Stimulus Glutathione Biosynthetic Process Aldehyde Catabolic Process Cellular Detoxification Of Aldehyde Metanephric Epithelium Development Muscle Cell Fate Commitment Nephron Tubule Morphogenesis Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation