CD81 and DLG5

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CD81	DLG5
Gene Name		CD81 molecule	discs, large homolog 5 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Membrane Vesicle Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Cell-cell Adherens Junction
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding	Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Receptor Signaling Complex Scaffold Activity
	Biological Process	Activation Of MAPK Activity Phosphatidylinositol Biosynthetic Process Protein Localization Cell Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Of B Cell Proliferation Positive Regulation Of 1-phosphatidylinositol 4-kinase Activity Phosphatidylinositol Metabolic Process Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Regulation Of Cell Motility	Protein Complex Assembly Signal Transduction Negative Regulation Of Cell Proliferation Single Organismal Cell-cell Adhesion Polarized Epithelial Cell Differentiation Midbrain Development Intracellular Signal Transduction Regulation Of Apoptotic Process Apical Protein Localization Zonula Adherens Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Epithelial Tube Branching Involved In Lung Morphogenesis Protein Localization To Adherens Junction Metanephric Collecting Duct Development
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS			Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Obesity-related traits ( 23251661)
Protein-Protein Interactions		20 interactors: ADRB2 CD19 CD9 CSNK2B DLG5 HNRNPD IFITM1 IGSF8 INO80B ITGA4 JAK3 KIT MYOC PTGFRN RBBP6 RNF128 SHC1 TSPAN4 VKORC1 ZBTB16	8 interactors: ABCA1 BTBD10 CD81 CTNNB1 DLST PFN1 SORBS3 TERF1
Entrez ID		975	9231
HPRD ID		08924	04972
Ensembl ID		ENSG00000110651	ENSG00000151208
Uniprot IDs		E9PJK1 P60033	Q8TDM6
PDB IDs		1G8Q 1IV5 2AVZ	1UIT
Enriched GO Terms of Interacting Partners?		Organ Development ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Proliferation System Development Regulation Of Immune Response Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Developmental Process Positive Regulation Of Ossification B Cell Differentiation Multicellular Organismal Development Anatomical Structure Development Movement Of Cell Or Subcellular Component Regulation Of Cell Motility Response To Stress Negative Regulation Of Cell Proliferation Regulation Of Locomotion Cell Activation Regulation Of Cellular Component Movement B Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Tissue Development Fibroblast Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Positive Regulation Of Signal Transduction Innate Immune Response Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Ossification Stem Cell Division Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Single Organismal Cell-cell Adhesion Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Cell Differentiation Bone Development Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Skeletal Muscle Hypertrophy Negative Regulation Of FasL Biosynthetic Process Zonula Adherens Assembly ERBB2-ERBB3 Signaling Pathway Mast Cell Proliferation Lymphocyte Differentiation	Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Organelle Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Protein Complex Assembly Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Phosphorylation Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Organelle Organization Regulation Of Protein Complex Assembly Positive Regulation Of Metabolic Process Regulation Of Stress Fiber Assembly Regulation Of Chromosome Segregation Positive Regulation Of MAPK Cascade Positive Regulation Of 1-phosphatidylinositol 4-kinase Activity Response To Drug Regulation Of Phosphorylation Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Protein Polymerization Regulation Of MAPK Cascade Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Telomeric Loop Formation Glial Cell Fate Determination Age-dependent Telomere Shortening Oviduct Development Regulation Of Centriole-centriole Cohesion Embryonic Epithelial Tube Formation Epithelial Tube Formation Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Determination Of Dorsal Identity Telomere Maintenance Via Telomere Shortening Lung Induction Interleukin-1 Beta Secretion Embryonic Skeletal Limb Joint Morphogenesis Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Tube Formation Cell Proliferation Morphogenesis Of Embryonic Epithelium
Tagcloud ?		000xg calreticulin centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin tsg101 ultracentrifugation vdac1 vesicle	12b 18rap 23r atg16l1 card15 card9 ccr6 crohn dmbt1 holds homeostatic ibd5 icoslg irf5 irgm itln1 loci lrrk2 mst1 nkx2 orchestration predispose ptger4 ptpn2 ptpn22 tl1a tnfrsf6b tnfsf15 xbp1
Tagcloud (Difference) ?		000xg calreticulin centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin tsg101 ultracentrifugation vdac1 vesicle	12b 18rap 23r atg16l1 card15 card9 ccr6 crohn dmbt1 holds homeostatic ibd5 icoslg irf5 irgm itln1 loci lrrk2 mst1 nkx2 orchestration predispose ptger4 ptpn2 ptpn22 tl1a tnfrsf6b tnfsf15 xbp1
Tagcloud (Intersection) ?