CD81 and CHRM4

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		CD81	CHRM4
Name		CD81 molecule	cholinergic receptor muscarinic 4
Structure
GO Annotations	Cellular Component	Immunological Synapse Cytosol Plasma Membrane Focal Adhesion Basal Plasma Membrane Membrane Basolateral Plasma Membrane Vesicle Extracellular Exosome Tetraspanin-enriched Microdomain	Plasma Membrane Membrane Dendrite Synapse Postsynaptic Membrane
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding Lipid Binding Cholesterol Binding MHC Class II Protein Complex Binding MHC Class II Protein Binding Transferrin Receptor Binding	G Protein-coupled Receptor Activity G Protein-coupled Acetylcholine Receptor Activity
	Biological Process	Immunological Synapse Formation Adaptive Immune Response Immune System Process Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Inflammatory Response To Antigenic Stimulus Myoblast Fusion Involved In Skeletal Muscle Regeneration Positive Regulation Of B Cell Proliferation Receptor Internalization Regulation Of Protein Stability Macrophage Fusion CD4-positive, Alpha-beta T Cell Costimulation Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation Protein Localization To Lysosome Positive Regulation Of Protein Exit From Endoplasmic Reticulum Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Localization To Plasma Membrane Osteoclast Fusion Positive Regulation Of Receptor Clustering Positive Regulation Of Protein Catabolic Process In The Vacuole Regulation Of Macrophage Migration Positive Regulation Of Adaptive Immune Memory Response Regulation Of Cell Motility Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Locomotion
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Regulation of Complement cascade	Muscarinic acetylcholine receptors G alpha (i) signalling events
Drugs		None	Ziprasidone Amitriptyline Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Procyclidine Loxapine Carbamoylcholine Hyoscyamine Meperidine Imipramine Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Tropicamide Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine ALKS 27 Fesoterodine Methacholine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Viloxazine Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
GWAS		Malaria ( 31844061 )	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Schizophrenia ( 28991256 29483656 )
Interacting Genes		62 interacting genes: ADRA1A ADRB2 AQP6 BDKRB2 BST2 CCR2 CCR9 CD19 CD79A CD9 CHRM4 CPLX4 CSNK2B DLG5 EBP ERGIC3 F2RL1 FAM209A FKBP7 GJA4 GLP1R GORAB GPR152 GPR35 GPX8 HNRNPD HRH1 HTR4 IFITM1 IGSF8 INO80B ITGA4 JAK3 KIT LBR LHFPL5 LMNA MC4R MCEE MRPS18B MYCBP2 MYOC NEMP1 OXTR PDZK1IP1 PTGFRN RBBP6 RNF128 SAR1A SDHAF4 SHC1 SIRPA SLC18A1 SLC26A6 STX1A THAP4 TMX2 TREX1 TSHR TSPAN4 VKORC1 ZBTB16	22 interacting genes: B2M CBFA2T3 CD59 CD81 CFTR EEF1A2 ERGIC3 GPRASP1 GRB2 MCL1 METTL9 QSOX1 RAB3A RHBDD2 RTN4 SLC60A1 SMIM7 SNCA SYN2 TM7SF2 TSPAN7 YIPF3
Entrez ID		975	1132
HPRD ID		08924	00330
Ensembl ID		ENSG00000110651	ENSG00000180720
Uniprot IDs		A6NMH8 E9PJK1 H0YEE2 P60033	P08173
PDB IDs		1G8Q 1IV5 3X0E 5DFV 5DFW 5M2C 5M33 5M3D 5M3T 5M4R 5TCX 6EJG 6EJM 6EK2 6U9S 7JIC	5DSG 6D9H 6KP6 7LD3 7LD4 7TRK 7TRP 7TRQ 7TRS 7V68 7V69 7V6A 8E9X 8FX5 8IYH 8IYW 8JER 8JHN
GO Terms Enriched among Interactors		G Protein-coupled Receptor Activity Membrane G Protein-coupled Receptor Signaling Pathway Plasma Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Tube Size System Process Regulation Of Multicellular Organismal Process Regulation Of Vasoconstriction Regulation Of System Process Negative Regulation Of Dendritic Cell Cytokine Production Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Circulatory System Process Regulation Of Locomotion Regulation Of Dendritic Cell Cytokine Production Myoblast Fusion Involved In Skeletal Muscle Regeneration G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Vascular Process In Circulatory System Cell Surface Receptor Signaling Pathway B Cell Differentiation B Cell Activation Leukocyte Differentiation Chemokine Receptor Activity Developmental Process Regulation Of Production Of Molecular Mediator Of Immune Response Secretion Regulation Of Cytokine Production Involved In Immune Response Cell Activation Cytokine-mediated Signaling Pathway Response To Psychosocial Stress Monocyte Extravasation Positive Regulation Of Vasoconstriction Regulation Of Cell Migration Mononuclear Cell Differentiation Leukocyte Activation Negative Regulation Of Viral Life Cycle Negative Regulation Of Multicellular Organismal Process Lymphocyte Activation Response To Interferon-beta Regulation Of Cell Motility Lymphocyte Differentiation Regulation Of Blood Circulation Regulation Of Blood Pressure Adrenergic Receptor Activity Protein Antigen Binding Ossification Involved In Bone Maturation Positive Regulation Of Cold-induced Thermogenesis	Membrane Neurotransmitter Secretion Regulation Of Chaperone-mediated Autophagy Golgi Membrane Receptor Internalization Synaptic Vesicle Clustering Positive Regulation Of Exocytosis Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Protein Localization Vesicle-mediated Transport In Synapse Endoplasmic Reticulum Membrane Neurotransmitter Transport Transport Vesicle Negative Regulation Of Autophagy Regulated Exocytosis Positive Regulation Of T Cell Cytokine Production Response To Iron Ion Positive Regulation Of Transport Regulation Of T Cell Cytokine Production MHC Class II Protein Complex Binding Leukocyte Mediated Immunity Amyloid Fibril Formation Regulation Of Cytokine Production Involved In Immune Response Lymphocyte Mediated Immunity Golgi Apparatus Regulation Of Aerobic Respiration Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Macrophage Fusion Vesicle-mediated Transport Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Cholesterol Biosynthetic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Autophagy Positive Regulation Of Lipid Kinase Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Synaptic Vesicle Calcium-ion Regulated Exocytosis Regulation Of Presynaptic Dense Core Granule Exocytosis Regulation Of Vesicle Fusion Synaptic Vesicle Transport Terminal Bouton Signal Release Vesicle Localization Synaptic Vesicle Exocytosis Evoked Neurotransmitter Secretion Synaptic Vesicle Membrane