CD81 and ADRA1A

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CD81	ADRA1A
Description		CD81 molecule	adrenoceptor alpha 1A
Image
GO Annotations	Cellular Component	Immunological Synapse Cytosol Plasma Membrane Focal Adhesion Basal Plasma Membrane Membrane Basolateral Plasma Membrane Vesicle Extracellular Exosome Tetraspanin-enriched Microdomain	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Caveola Membrane Nuclear Membrane
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding Lipid Binding Cholesterol Binding MHC Class II Protein Complex Binding MHC Class II Protein Binding Transferrin Receptor Binding	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha1-adrenergic Receptor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Immunological Synapse Formation Adaptive Immune Response Immune System Process Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Inflammatory Response To Antigenic Stimulus Myoblast Fusion Involved In Skeletal Muscle Regeneration Positive Regulation Of B Cell Proliferation Receptor Internalization Regulation Of Protein Stability Macrophage Fusion CD4-positive, Alpha-beta T Cell Costimulation Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation Protein Localization To Lysosome Positive Regulation Of Protein Exit From Endoplasmic Reticulum Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Localization To Plasma Membrane Osteoclast Fusion Positive Regulation Of Receptor Clustering Positive Regulation Of Protein Catabolic Process In The Vacuole Regulation Of Macrophage Migration Positive Regulation Of Adaptive Immune Memory Response Regulation Of Cell Motility Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell	MAPK Cascade Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Apoptotic Process Regulation Of Muscle Contraction Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Adult Heart Development Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Hormone Negative Regulation Of Autophagy Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Vasoconstriction Positive Regulation Of Synaptic Transmission, GABAergic Organ Growth Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Action Potential Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Regulation Of Cardiac Muscle Contraction Positive Regulation Of Cardiac Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Phospholipase C-activating Adrenergic Receptor Signaling Pathway Pilomotor Reflex Neuron-glial Cell Signaling
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Regulation of Complement cascade	Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events
Drugs			Amphetamine Midodrine Ranolazine Ziprasidone Cabergoline Ropinirole Dapiprazole Dihydroergotamine Amitriptyline Olanzapine Alfuzosin Alfuzosin Clozapine Norepinephrine Mirtazapine Phenylephrine Loxapine Promazine Prochlorperazine Dipivefrin Droperidol Prazosin Prazosin Imipramine Chlorpromazine Chlorpromazine Buspirone Haloperidol Nortriptyline Amoxapine Amoxapine Lamotrigine Clonidine Doxazosin Labetalol Metaraminol Nicardipine Trazodone Verapamil Epinephrine Thioridazine Phentolamine Ergotamine Tizanidine Nicergoline Tamsulosin Paroxetine Methoxamine Trimipramine Risperidone Epinastine Propiomazine Tolazoline Fenoldopam Trifluoperazine Dobutamine Pseudoephedrine Benzphetamine Flupentixol Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Ergoloid mesylate Promethazine Carvedilol Carvedilol Doxepin Nefazodone Desipramine Terazosin Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Ergometrine Paliperidone Bevantolol Ephedrine Mephentermine Methotrimeprazine 4-Methoxyamphetamine Dextroamphetamine Phendimetrazine Acepromazine Thioproperazine Zuclopenthixol Dronedarone Iloperidone Lofexidine R450 Epicept NP-1 Cariprazine Sertindole Mianserin Pizotifen Silodosin Asenapine Ocaperidone Droxidopa Xylometazoline Isometheptene Naphazoline Tetryzoline Perospirone Indoramin Dosulepin Etoperidone Lorpiprazole Cirazoline Synephrine Arotinolol Moxisylyte Aranidipine Niguldipine Pipamperone Racepinephrine Dihydroergocornine DL-Methylephedrine Indigotindisulfonic acid Propiverine Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Malaria ( 31844061)	Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Response to amphetamines ( 22952603) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		62 interacting genes: ADRA1A ADRB2 AQP6 BDKRB2 BST2 CCR2 CCR9 CD19 CD79A CD9 CHRM4 CPLX4 CSNK2B DLG5 EBP ERGIC3 F2RL1 FAM209A FKBP7 GJA4 GLP1R GORAB GPR152 GPR35 GPX8 HNRNPD HRH1 HTR4 IFITM1 IGSF8 INO80B ITGA4 JAK3 KIT LBR LHFPL5 LMNA MC4R MCEE MRPS18B MYCBP2 MYOC NEMP1 OXTR PDZK1IP1 PTGFRN RBBP6 RNF128 SAR1A SDHAF4 SHC1 SIRPA SLC18A1 SLC26A6 STX1A THAP4 TMX2 TREX1 TSHR TSPAN4 VKORC1 ZBTB16	30 interacting genes: ABR ADGRA3 ADRA1B ADRA1D ANO8 ATP6AP2 BMP1 CD81 CXCR1 CXCR2 FAM241B FAM50B FLNC GDE1 GPR37 HHATL KIAA2013 KLHL22 MBOAT7 NOS1 NTNG2 PPP1R9B RGS2 SCN1B SGCB TBC1D20 TMEM234 TPCN2 UBR4 UGT8
Entrez ID		975	148
HPRD ID		08924	00081
Ensembl ID		ENSG00000110651	ENSG00000120907
Uniprot IDs		A6NMH8 E9PJK1 H0YEE2 P60033	B0ZBD3 P35348
PDB IDs		1G8Q 1IV5 3X0E 5DFV 5DFW 5M2C 5M33 5M3D 5M3T 5M4R 5TCX 6EJG 6EJM 6EK2 6U9S 7JIC	7YM8 7YMH 7YMJ 8HN1 8THK 8THL
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity Membrane G Protein-coupled Receptor Signaling Pathway Plasma Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Tube Size System Process Regulation Of Multicellular Organismal Process Regulation Of Vasoconstriction Regulation Of System Process Negative Regulation Of Dendritic Cell Cytokine Production Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Circulatory System Process Regulation Of Locomotion Regulation Of Dendritic Cell Cytokine Production Myoblast Fusion Involved In Skeletal Muscle Regeneration G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Vascular Process In Circulatory System Cell Surface Receptor Signaling Pathway B Cell Differentiation B Cell Activation Leukocyte Differentiation Chemokine Receptor Activity Developmental Process Regulation Of Production Of Molecular Mediator Of Immune Response Secretion Regulation Of Cytokine Production Involved In Immune Response Cell Activation Cytokine-mediated Signaling Pathway Response To Psychosocial Stress Monocyte Extravasation Positive Regulation Of Vasoconstriction Regulation Of Cell Migration Mononuclear Cell Differentiation Leukocyte Activation Negative Regulation Of Viral Life Cycle Negative Regulation Of Multicellular Organismal Process Lymphocyte Activation Response To Interferon-beta Regulation Of Cell Motility Lymphocyte Differentiation Regulation Of Blood Circulation Regulation Of Blood Pressure Adrenergic Receptor Activity Protein Antigen Binding Ossification Involved In Bone Maturation Positive Regulation Of Cold-induced Thermogenesis	Membrane Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Alpha1-adrenergic Receptor Activity Calcium-mediated Signaling Interleukin-8 Binding Neuron-glial Cell Signaling G Protein-coupled Receptor Activity Regulation Of Blood Circulation C-X-C Chemokine Receptor Activity Adrenergic Receptor Activity Plasma Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Receptor-mediated Endocytosis Dendritic Spine Membrane Receptor Internalization Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Heart Contraction Regulation Of Cardiac Muscle Contraction Dendritic Cell Chemotaxis Positive Regulation Of Sodium Ion Transmembrane Transport Intracellular Signaling Cassette Adrenergic Receptor Signaling Pathway Regulation Of Striated Muscle Contraction Intercellular Bridge Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Response To Immobilization Stress Dendritic Cell Migration Regulation Of MAPK Cascade Sarcolemma Muscle System Process Myoblast Fusion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Macrophage Fusion Cell-cell Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Syncytium Formation By Plasma Membrane Fusion Transmembrane Transporter Binding Sodium Channel Regulator Activity Regulation Of Membrane Repolarization Positive Regulation Of Sodium Ion Transport Response To Amphetamine Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Corticospinal Neuron Axon Guidance N-acylsphingosine Galactosyltransferase Activity
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