SLK and PDZK1

Number of citations of the paper that reports this interaction (PMID 14531806)
31

Data Source:
BioGRID (two hybrid, pull down)

		SLK	PDZK1
Gene Name		STE20-like kinase	PDZ domain containing 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity ATP Binding Identical Protein Binding Protein Homodimerization Activity	Scavenger Receptor Binding Transporter Activity Protein Binding PDZ Domain Binding Protein Complex Binding
	Biological Process	Apoptotic Process Signal Transduction By Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation	Transport Cell Proliferation Carnitine Transport Drug Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Anion Transport Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane
Pathways
Drugs
Diseases
GWAS		Uterine fibroids ( 21460842)	Urate levels ( 20884846 23263486) Uric acid levels ( 19503597)
Protein-Protein Interactions		3 interactors: CASP3 CLSTN1 PDZK1	27 interactors: ABCA1 ABCC2 ABCC4 AKAP10 APP CFTR CLCN3 FARP2 GFAP PDZK1IP1 PEX5 SCARB1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A3 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I
Entrez ID		9748	5174
HPRD ID		11585	04829
Ensembl ID		ENSG00000065613	ENSG00000174827
Uniprot IDs		Q9H2G2	Q5T2W1
PDB IDs		2J51 2JFL 2JFM 2UV2	2EEI 2EEJ 2VSP 3TMH
Enriched GO Terms of Interacting Partners?		Glial Cell Apoptotic Process Regulation Of Apoptotic DNA Fragmentation Carnitine Transport Negative Regulation Of Activated T Cell Proliferation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Negative Regulation Of B Cell Proliferation Quaternary Ammonium Group Transport Apoptotic DNA Fragmentation Platelet Formation Platelet Morphogenesis Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Hippo Signaling Release Of Cytochrome C From Mitochondria Apoptotic Nuclear Changes Positive Regulation Of Protein Targeting To Membrane Regulation Of Activated T Cell Proliferation B Cell Homeostasis T Cell Homeostasis Negative Regulation Of B Cell Activation	Anion Transport Transmembrane Transport Anion Transmembrane Transport Organic Anion Transport Ion Transport Ion Transmembrane Transport Homeostatic Process Chemical Homeostasis Ion Homeostasis Monocarboxylic Acid Transport Inorganic Anion Transport Transport Organic Acid Transport Anion Homeostasis Urate Metabolic Process Sodium Ion Transport Cellular Ion Homeostasis Cellular Homeostasis Lipid Transport Regulation Of PH Carboxylic Acid Transport Response To Drug Cellular Chemical Homeostasis Lipid Localization Monovalent Inorganic Cation Transport Antibiotic Transport Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Intracellular PH Regulation Of Cellular PH Sterol Metabolic Process Drug Transport Cellular Phosphate Ion Homeostasis Intracellular PH Elevation Cell Maturation Sodium-dependent Phosphate Transport Transepithelial Chloride Transport Neuron Remodeling Secretion Cholesterol Transport Sterol Transport Oligopeptide Transport Carnitine Transmembrane Transport Carnitine Transport Small Molecule Metabolic Process Transepithelial Transport Phosphate Ion Homeostasis Phosphate Ion Transmembrane Transport Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Peptide Transport
Tagcloud ?		chorionic commercial complementary crude deoxynucleotidyl deoxyuridine digoxigenin exhibiting fractions furthered go gonadotropin haf hcg immunodeficiency inoculation kaposi ks neoplastic nick preceded pregnancy preparations rel sarcoma transferase triphosphate tunel y	across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows
Tagcloud (Difference) ?		chorionic commercial complementary crude deoxynucleotidyl deoxyuridine digoxigenin exhibiting fractions furthered go gonadotropin haf hcg immunodeficiency inoculation kaposi ks neoplastic nick preceded pregnancy preparations rel sarcoma transferase triphosphate tunel y	across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows
Tagcloud (Intersection) ?