SLK and CLSTN1

Number of citations: 39 (PubMedID 12421765)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		SLK	CLSTN1
Name		STE20 like kinase	calsyntenin 1
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell Leading Edge Perinuclear Region Of Cytoplasm Extracellular Exosome	Golgi Membrane Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cell Surface Postsynaptic Density Membrane Cell Projection Neuron Projection Synapse Postsynaptic Membrane Postsynaptic Endosome Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Serine Kinase Activity	Amyloid-beta Binding Calcium Ion Binding Protein Binding Kinesin Binding X11-like Protein Binding
	Biological Process	Apoptotic Process Regulation Of Cell Migration Cytoplasmic Microtubule Organization Intracellular Signal Transduction Regulation Of Apoptotic Process Protein Autophosphorylation Regulation Of Focal Adhesion Assembly	Regulation Of Cell Growth Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Positive Regulation Of Synaptic Transmission Positive Regulation Of Synapse Assembly Regulation Of Synapse Maturation Neurotransmitter Receptor Transport To Postsynaptic Membrane Vesicle-mediated Transport In Synapse
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	None
Drugs		K-00546 2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile Fostamatinib	None
GWAS		Diastolic blood pressure ( 29403010 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) Mean corpuscular hemoglobin ( 29403010 ) Mean corpuscular volume ( 29403010 ) Neuroblastoma or malignant cutaneous melanoma ( 31605138 ) Pulse pressure ( 30487518 ) Systolic blood pressure ( 30487518 ) Uterine fibroids ( 21460842 31649266 )	No GWAS studies recorded
Interacting Genes		3 interacting genes: CASP3 CLSTN1 PDZK1	14 interacting genes: APBA2 APBB1 BAHCC1 COL17A1 KIF2A KLC1 KLC2 MCM3AP MDM2 PRNP SETDB1 SLK TOPBP1 TRIP12
Entrez ID		9748	22883
HPRD ID		11585	10837
Ensembl ID		ENSG00000065613	ENSG00000171603
Uniprot IDs		Q9H2G2	B4E3Q1 O94985
PDB IDs		2J51 2JFL 2JFM 2UV2 4USF 6HVD 8BEM	Not available
GO Terms Enriched among Interactors		Response To Anesthetic Anterior Neural Tube Closure Postsynaptic Density Protein-containing Complex Binding Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Cellular Response To Staurosporine Death-inducing Signaling Complex Luteolysis Glial Cell Apoptotic Process Phospholipase A2 Activator Activity Protein Localization To Cell Periphery Scavenger Receptor Binding Carnitine Transmembrane Transport Carnitine Transport Protein Localization To Membrane X11-like Protein Binding Postsynaptic Endosome Positive Regulation Of Pyroptotic Inflammatory Response Response To Cobalt Ion Fibroblast Apoptotic Process Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Transporter Activator Activity Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Regulation Of Synaptic Vesicle Cycle Interleukin-18-mediated Signaling Pathway Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Activated T Cell Proliferation Regulation Of Monoatomic Anion Transport Xenobiotic Export From Cell Quaternary Ammonium Group Transport Neurotransmitter Receptor Transport Localization Within Membrane Negative Regulation Of B Cell Proliferation Death Receptor Binding Glutamatergic Synapse Protein Poly-ADP-ribosylation Positive Regulation Of Amyloid-beta Formation Aspartic-type Endopeptidase Activity Axonal Fasciculation Neuron Projection Fasciculation Platelet Formation Neurotrophin Signaling Pathway Positive Regulation Of Amyloid Precursor Protein Catabolic Process Response To X-ray Execution Phase Of Apoptosis Microvillus Membrane	Kinesin Complex Amyloid-beta Binding Heterochromatin Organization Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Chromatin Organization Chromatin Binding Cytoskeletal Motor Activity Kinesin Binding Response To Formaldehyde Cellular Response To Vitamin B1 Type 8 Metabotropic Glutamate Receptor Binding Kinesin I Complex Regulation Of Protein Processing Protein Destabilization Regulation Of Protein Maturation