USP6NL and EPS8

Number of citations of the paper that reports this interaction (PubMedID 8700527)
0

Data Source:
HPRD (in vivo)

		USP6NL	EPS8
Description		USP6 N-terminal like	EGFR pathway substrate 8, signaling adaptor
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane	Cytoplasm Plasma Membrane Brush Border Cell Cortex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Growth Cone Vesicle Stereocilium Stereocilium Bundle Stereocilium Tip Ruffle Membrane Cell Projection Neuron Projection Synapse Extracellular Exosome Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding	Actin Binding Protein Binding Small GTPase Binding
	Biological Process	Golgi Organization Virion Assembly Retrograde Transport, Plasma Membrane To Golgi Positive Regulation Of GTPase Activity Plasma Membrane To Endosome Transport Regulation Of Cilium Assembly Regulation Of Golgi Organization	Rho Protein Signal Transduction Adult Locomotory Behavior Regulation Of Cell Shape Exit From Mitosis Rac Protein Signal Transduction Actin Cytoskeleton Organization Regulation Of Actin Filament Length Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Ruffle Assembly Cellular Response To Leukemia Inhibitory Factor
Pathways		Retrograde transport at the Trans-Golgi-Network	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) LDL levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Obesity-related traits ( 23251661)	Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913)
Interacting Genes		6 interacting genes: ACTA1 ACTN4 APP EPS8 GRB2 RAB5A	61 interacting genes: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BORCS6 BYSL C19orf25 C6orf141 C8orf33 CASK CBL CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 ITSN2 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RCAN3 RFXAP RSPH14 RUNX1T1 SCRN3 SERPINA5 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XAGE2 XRCC6 ZZZ3
Entrez ID		9712	2059
HPRD ID		08957	02563
Ensembl ID		ENSG00000148429	ENSG00000151491
Uniprot IDs		Q92738 X6RAB3	B4E3T6 Q12929
PDB IDs			2E8M 7TZK
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Regulation Of Long-term Neuronal Synaptic Plasticity Ephrin Receptor Binding Cell Development Cell Body Actin Cytoskeleton Stress Fiber Actin Filament-based Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Platelet Alpha Granule Lumen Cell Projection Actin Cytoskeleton Organization Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Adult Locomotory Behavior Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Supramolecular Fiber Organization Positive Regulation Of Toll Signaling Pathway Endocytosis Positive Regulation Of Reactive Oxygen Species Metabolic Process Glial Cell Development Regulation Of Cellular Component Size Receptor Internalization Guanyl-nucleotide Exchange Factor Adaptor Activity Supramolecular Fiber Organization Muscle Cell Development Regulation Of Non-canonical NF-kappaB Signal Transduction Nucleoside Binding Positive Regulation Of Sodium:proton Antiporter Activity Acetylcholine Receptor Activator Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Growth Cone Lipoprotein Particle Import Into Cell Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length	Epidermal Growth Factor Receptor Signaling Pathway Filopodium ERBB Signaling Pathway Protein Tyrosine Kinase Activator Activity Supramolecular Fiber Organization Actin Filament Organization Symbiont Entry Into Host Cell Ephrin Receptor Binding Actin Filament Bundle Organization Actin Filament Bundle Assembly Shc-EGFR Complex Focal Adhesion Enzyme-linked Receptor Protein Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Phosphotyrosine Residue Binding Biological Process Involved In Interaction With Host Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Process Schwann Cell Development Ruffle SH3 Domain Binding Cellular Response To Growth Factor Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Epidermal Growth Factor Binding ERBB2 Signaling Pathway Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Response To Platelet-derived Growth Factor Neuregulin Binding Integrin Complex C-X3-C Chemokine Binding Cell Adhesion Mediated By Integrin Response To Growth Factor Wound Healing, Spreading Of Cells Response To Activity Neurotrophin TRKA Receptor Binding Endocytosis Insulin Receptor Signaling Pathway Integrin Binding Virus Receptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Binding Heterotypic Cell-cell Adhesion Actin-based Cell Projection Cellular Developmental Process Import Into Cell Schaffer Collateral - CA1 Synapse Ruffle Membrane Integrin-mediated Signaling Pathway Lamellipodium
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