USP6NL and EPS8

Number of citations of the paper that reports this interaction (PMID 11099046)
68

Data Source:
HPRD (in vivo)

		USP6NL	EPS8
Gene Name		USP6 N-terminal like	epidermal growth factor receptor pathway substrate 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Cytoplasmic Vesicle	Cell Cortex Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Growth Cone Vesicle Stereocilium Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	Rab GTPase Activator Activity Rab GTPase Binding	Actin Binding SH3/SH2 Adaptor Activity Protein Binding Rac GTPase Binding
	Biological Process	Golgi Organization Virion Assembly Positive Regulation Of Rab GTPase Activity Retrograde Transport, Plasma Membrane To Golgi Plasma Membrane To Endosome Transport Regulation Of Cilium Assembly Regulation Of Golgi Organization	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Adult Locomotory Behavior Regulation Of Cell Shape Positive Regulation Of Signal Transduction Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Actin Cytoskeleton Reorganization Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		6 interactors: ACTA1 ACTN4 APP EPS8 GRB2 RAB5A	54 interactors: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BYSL C17orf59 C19orf25 C8orf33 CASK CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RFXAP RUNX1T1 SCRN3 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XRCC6 ZZZ3
Entrez ID		9712	2059
HPRD ID		08957	02563
Ensembl ID		ENSG00000148429	ENSG00000151491
Uniprot IDs		Q92738	B4DX66 B4E3T6 Q12929
PDB IDs			2E8M
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Actin Crosslink Formation Platelet Activation Response To Wounding Ras Protein Signal Transduction Cellular Component Assembly Actin Filament Organization Receptor Internalization Regulation Of Cellular Component Size Response To Abiotic Stimulus Actin Filament Bundle Assembly Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Receptor Metabolic Process Vesicle-mediated Transport Movement Of Cell Or Subcellular Component Actin Cytoskeleton Organization Small GTPase Mediated Signal Transduction Adult Locomotory Behavior Actin Filament-based Process Endocytosis Cell Activation Cellular Response To Stimulus Skeletal Muscle Fiber Adaptation Synaptic Growth At Neuromuscular Junction Cell Growth Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway Adult Behavior ERBB Signaling Pathway Collateral Sprouting In Absence Of Injury Protein Localization To Tight Junction Receptor Internalization Involved In Canonical Wnt Signaling Pathway Actin Polymerization-dependent Cell Motility Regulation Of Endosome Size Positive Regulation Of Pinocytosis Regulation Of Actin Filament Polymerization Regulation Of Endocytosis Positive Regulation Of Sodium:proton Antiporter Activity Intracellular Receptor Signaling Pathway Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Collateral Sprouting Axon Midline Choice Point Recognition Leukocyte Migration Locomotory Behavior	Cell Differentiation Developmental Process Movement Of Cell Or Subcellular Component Multicellular Organismal Development System Development Anatomical Structure Development Cell Projection Morphogenesis Cell Part Morphogenesis Axonogenesis Axon Guidance Fc Receptor Signaling Pathway Axon Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Morphogenesis Chemotaxis Neurogenesis Neuron Projection Development Immune Response-regulating Signaling Pathway Neuron Projection Morphogenesis Organelle Organization Positive Regulation Of Signal Transduction Cell Morphogenesis Leukocyte Migration Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Generation Of Neurons Cell Development Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Development Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Hemostasis Regulation Of ERBB Signaling Pathway Nervous System Development Innate Immune Response Anatomical Structure Formation Involved In Morphogenesis Regulation Of Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Phosphorylation Regulation Of Immune System Process Platelet Activation Response To Fibroblast Growth Factor
Tagcloud ?			adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound
Tagcloud (Difference) ?			adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound
Tagcloud (Intersection) ?