HDAC8 and MDC1

Number of citations of the paper that reports this interaction (PubMedID 14578343)
0

Data Source:
BioGRID (unspecified method)

		HDAC8	MDC1
Description		histone deacetylase 8	mediator of DNA damage checkpoint 1
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body Site Of Double-strand Break
	Molecular Function	Histone Deacetylase Activity Protein Binding Hydrolase Activity Hsp70 Protein Binding Protein Lysine Deacetylase Activity Metal Ion Binding Hsp90 Protein Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Decrotonylase Activity Histone Decrotonylase Activity	Protein Binding Chromatin-protein Adaptor Activity Histone Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Mitotic Sister Chromatid Cohesion Negative Regulation Of Protein Ubiquitination Heterochromatin Formation Regulation Of Protein Stability Regulation Of Telomere Maintenance	DNA Replication Checkpoint Signaling DNA Repair Chromatin Organization DNA Damage Response Mitotic Intra-S DNA Damage Checkpoint Signaling Protein K6-linked Ubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway	SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint
Drugs		Valproic acid Decitabine Iron Zinc Vorinostat Vorinostat 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-Thienyl]Sulfonyl}Amino)Benzamide Trichostatin A Belinostat Romidepsin Panobinostat Phenylbutyric acid (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide 5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4'-HYDROXYAMIDE Coumarin 120 Entinostat Abexinostat Givinostat Pyroxamide Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Autism spectrum disorder ( 34069769) Chloride levels ( 29403010) Sodium levels ( 29403010)	Autism spectrum disorder or schizophrenia ( 28540026) Eosinophil count ( 31272903)
Interacting Genes		9 interacting genes: ESRRA H3-4 H3C1 H4C1 H4C16 MDC1 PRKACA RTN1 RUNX1T1	42 interacting genes: ANAPC1 ATM BARD1 BDKRB1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 PTEN RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 USP7 VAMP5 WRN ZNF251
Entrez ID		55869	9656
HPRD ID		02227	16252
Ensembl ID		ENSG00000147099	ENSG00000137337
Uniprot IDs		A0A3B3IS68 A0A3B3ISS7 A0A3B3IT30 A0A3B3IU01 A6NFW1 Q9BY41	A0A1U9XBC1 A0A1U9XBE3 A0A1U9XBF2 A1Z5I9 Q14676
PDB IDs		1T64 1T67 1T69 1VKG 1W22 2V5W 2V5X 3EW8 3EWF 3EZP 3EZT 3F06 3F07 3F0R 3MZ3 3MZ4 3MZ6 3MZ7 3RQD 3SFF 3SFH 4QA0 4QA1 4QA2 4QA3 4QA4 4QA5 4QA6 4QA7 4RN0 4RN1 4RN2 5BWZ 5D1B 5D1C 5D1D 5DC5 5DC6 5DC7 5DC8 5FCW 5THS 5THT 5THU 5THV 5VI6 6HSK 6ODA 6ODB 6ODC 7JVU 7JVV 7JVW	2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT 9IF9
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Nucleosome Organization Protein-DNA Complex Assembly Chromosome Protein Heterodimerization Activity Protein Localization To Chromosome Chromatin Organization Telomere Organization CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Nucleoplasm Chromosome, Telomeric Region Regulation Of Megakaryocyte Differentiation DNA Binding Protein Localization To Organelle Protein-containing Complex Assembly Protein Localization To Chromosome, Centromeric Region Chromatin Remodeling Protein Localization To Chromatin Protein-containing Complex Organization Cellular Component Assembly Regulation Of Cell Differentiation Chromosome Organization Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Extracellular Exosome Spermatogonial Cell Division Nucleus CAMP-dependent Protein Kinase Activity Endoplasmic Reticulum Tubular Network Formation	DNA Repair DNA Damage Response DNA Metabolic Process Double-strand Break Repair Regulation Of Cellular Response To Stress Nucleoplasm Regulation Of DNA Metabolic Process Regulation Of DNA Repair Response To Ionizing Radiation Response To Radiation Negative Regulation Of Cell Cycle Phase Transition Cellular Response To Stress DNA Damage Checkpoint Signaling Post-translational Protein Modification Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Positive Regulation Of DNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome DNA Recombination Nucleic Acid Metabolic Process Regulation Of DNA Recombination Nucleus Regulation Of Double-strand Break Repair Regulation Of Cell Cycle Phase Transition Chromatin Remodeling PML Body Macromolecule Metabolic Process Protein Modification Process Chromatin Organization Cellular Response To Radiation Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Macromolecule Metabolic Process Response To Stress Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Positive Regulation Of DNA Repair Recombinational Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Site Of Double-strand Break Regulation Of Primary Metabolic Process Homologous Recombination Ubiquitin-modified Histone Reader Activity Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Process Cellular Response To Ionizing Radiation Positive Regulation Of DNA Recombination
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