HDAC8

Description		histone deacetylase 8
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm
	Molecular Function	Histone Deacetylase Activity Protein Binding Hydrolase Activity Hsp70 Protein Binding Protein Lysine Deacetylase Activity Metal Ion Binding Hsp90 Protein Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Decrotonylase Activity Histone Decrotonylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Mitotic Sister Chromatid Cohesion Negative Regulation Of Protein Ubiquitination Heterochromatin Formation Regulation Of Protein Stability Regulation Of Telomere Maintenance
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway
Drugs		Valproic acid Decitabine Iron Zinc Vorinostat Vorinostat 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-Thienyl]Sulfonyl}Amino)Benzamide Trichostatin A Belinostat Romidepsin Panobinostat Phenylbutyric acid (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide 5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4'-HYDROXYAMIDE Coumarin 120 Entinostat Abexinostat Givinostat Pyroxamide Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Autism spectrum disorder ( 34069769) Chloride levels ( 29403010) Sodium levels ( 29403010)
Interacting Genes		9 interacting genes: ESRRA H3-4 H3C1 H4C1 H4C16 MDC1 PRKACA RTN1 RUNX1T1
Entrez ID		55869
HPRD ID		02227
Ensembl ID		ENSG00000147099
Uniprot IDs		A0A3B3IS68 A0A3B3ISS7 A0A3B3IT30 A0A3B3IU01 A6NFW1 Q9BY41
PDB IDs		1T64 1T67 1T69 1VKG 1W22 2V5W 2V5X 3EW8 3EWF 3EZP 3EZT 3F06 3F07 3F0R 3MZ3 3MZ4 3MZ6 3MZ7 3RQD 3SFF 3SFH 4QA0 4QA1 4QA2 4QA3 4QA4 4QA5 4QA6 4QA7 4RN0 4RN1 4RN2 5BWZ 5D1B 5D1C 5D1D 5DC5 5DC6 5DC7 5DC8 5FCW 5THS 5THT 5THU 5THV 5VI6 6HSK 6ODA 6ODB 6ODC 7JVU 7JVV 7JVW
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Nucleosome Organization Protein-DNA Complex Assembly Chromosome Protein Heterodimerization Activity Protein Localization To Chromosome Chromatin Organization Telomere Organization CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Nucleoplasm Chromosome, Telomeric Region Regulation Of Megakaryocyte Differentiation DNA Binding Protein Localization To Organelle Protein-containing Complex Assembly Protein Localization To Chromosome, Centromeric Region Chromatin Remodeling Protein Localization To Chromatin Protein-containing Complex Organization Cellular Component Assembly Regulation Of Cell Differentiation Chromosome Organization Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Extracellular Exosome Spermatogonial Cell Division Nucleus CAMP-dependent Protein Kinase Activity Endoplasmic Reticulum Tubular Network Formation
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