HDAC8 and RTN1

Number of citations of the paper that reports this interaction (PMID 19140693)
3

Data Source:
BioGRID (fluorescent resonance energy transfer)

		HDAC8	RTN1
Gene Name		histone deacetylase 8	reticulon 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Histone Deacetylase Activity Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)	Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Chromatin Organization Chromatin Assembly Or Disassembly Transcription, DNA-templated Sister Chromatid Cohesion Chromatin Modification Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Regulation Of Cohesin Localization To Chromatin	Neuron Differentiation
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Chromatin organization HDACs deacetylate histones Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs		Vorinostat 4-Dimethylamino-N-(6-Hydroxycarbamoyethyl)Benzamide-N-Hydroxy-7-(4-Dimethyla Minobenzoyl)Aminoheptanamide N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-Thienyl]Sulfonyl}Amino)Benzamide 7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide 5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4\'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4\'-HYDROXYAMIDE 7-AMINO-4-METHYL-CHROMEN-2-ONE
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ESRRA HIST1H3A HIST1H4A HIST3H3 HIST4H4 MDC1 PRKACA RTN1 RUNX1T1	7 interactors: BCL2L1 FAM160A2 HDAC8 PLEKHF2 SDCBP SPAST UGCG
Entrez ID		55869	6252
HPRD ID		02227	02921
Ensembl ID		ENSG00000147099	ENSG00000139970
Uniprot IDs		Q9BY41	A8K3B9 Q16799
PDB IDs		1T64 1T67 1T69 1VKG 1W22 2V5W 2V5X 3EW8 3EWF 3EZP 3EZT 3F06 3F07 3F0R 3MZ3 3MZ4 3MZ6 3MZ7 3RQD 3SFF 3SFH
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Nucleosome Assembly DNA Methylation On Cytosine Chromatin Silencing At RDNA Chromatin Silencing Regulation Of Myeloid Cell Differentiation Histone H4-K20 Demethylation DNA Methylation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance DNA Modification Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Gene Silencing Nucleosome Assembly Chromatin Assembly Chromosome Organization Nucleosome Organization DNA Metabolic Process Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Regulation Of Megakaryocyte Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein-DNA Complex Assembly Negative Regulation Of Cellular Metabolic Process DNA Packaging CENP-A Containing Nucleosome Assembly Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange DNA Replication-independent Nucleosome Assembly Histone Lysine Demethylation Histone Demethylation Chromatin Organization Protein Demethylation Mitotic Cell Cycle DNA Conformation Change Centromere Complex Assembly Nucleobase-containing Compound Metabolic Process Demethylation ATP-dependent Chromatin Remodeling Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Modification Positive Regulation Of Dense Core Granule Biogenesis Methylation Cellular Nitrogen Compound Metabolic Process	Regulation Of Organelle Organization Apoptotic Process In Bone Marrow Glucosylceramide Biosynthetic Process Cytokinesis Intracellular Transport Organelle Organization Cytokinesis, Completion Of Separation Mitotic Cell Cycle Positive Regulation Of Extracellular Vesicular Exosome Assembly Suppression By Virus Of Host Apoptotic Process Regulation Of Cohesin Localization To Chromatin Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Depolymerization Glucosylceramide Metabolic Process Establishment Of Localization In Cell Cell Part Morphogenesis Regulation Of Extracellular Vesicular Exosome Assembly Response To Cycloheximide Cellular Process Regulating Host Cell Cycle In Response To Virus Mitotic Cytokinetic Process Protein Hexamerization Negative Regulation Of Execution Phase Of Apoptosis Regulation Of Cellular Localization Cell Cycle Process Cellular Localization Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Substrate-dependent Cell Migration, Cell Extension Cellular Response To Virus Microtubule Severing Modulation By Virus Of Host Process Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Anoikis Cellular Response To Gamma Radiation Hepatocyte Apoptotic Process Regulation Of Sister Chromatid Cohesion Cell Cycle Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Anoikis Cell Separation After Cytokinesis Positive Regulation Of Protein Depolymerization Transport Positive Regulation Of Organelle Organization Protein Transport Early Endosome To Late Endosome Transport Negative Regulation Of Protein Localization To Plasma Membrane Cell Division Vesicle-mediated Transport Mitochondrion Morphogenesis Modulation By Virus Of Host Morphology Or Physiology
Tagcloud ?		activator acylthiourea anticancer calorimetric conformed cooperative deacetylase derivative detailed discriminatory encoded feature insight isothermal isozyme kinetic kinetics malignancy mechanistic modeling neuroblastoma served sh steady sy5y thermodynamics titration tm wherein	astrocyte clues constitute exert explore fi fl galactosidase glutathione homo immuno interacting library manf media mesencephalic neurotrophic proapoptotic pull regular reticular reticulons rtns sapiens screen speci transferase uorescence verified
Tagcloud (Difference) ?		activator acylthiourea anticancer calorimetric conformed cooperative deacetylase derivative detailed discriminatory encoded feature insight isothermal isozyme kinetic kinetics malignancy mechanistic modeling neuroblastoma served sh steady sy5y thermodynamics titration tm wherein	astrocyte clues constitute exert explore fi fl galactosidase glutathione homo immuno interacting library manf media mesencephalic neurotrophic proapoptotic pull regular reticular reticulons rtns sapiens screen speci transferase uorescence verified
Tagcloud (Intersection) ?