HDAC8 and ESRRA

Number of citations of the paper that reports this interaction (PMID 20484414)
22

Data Source:
BioGRID (enzymatic study)

		HDAC8	ESRRA
Gene Name		histone deacetylase 8	estrogen-related receptor alpha
Image
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Nucleus Nucleoplasm Nucleolus Microtubule Cytoskeleton Intercellular Bridge
	Molecular Function	Histone Deacetylase Activity Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Steroid Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Chromatin Organization Chromatin Assembly Or Disassembly Transcription, DNA-templated Sister Chromatid Cohesion Chromatin Modification Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Regulation Of Cohesin Localization To Chromatin	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Organelle Organization Mitochondrion Organization Gene Expression Intracellular Receptor Signaling Pathway Regulation Of Cell Proliferation Steroid Hormone Mediated Signaling Pathway Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cartilage Development
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Chromatin organization HDACs deacetylate histones Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Nuclear Receptor transcription pathway Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs		Vorinostat 4-Dimethylamino-N-(6-Hydroxycarbamoyethyl)Benzamide-N-Hydroxy-7-(4-Dimethyla Minobenzoyl)Aminoheptanamide N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-Thienyl]Sulfonyl}Amino)Benzamide 7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide 5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4\'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4\'-HYDROXYAMIDE 7-AMINO-4-METHYL-CHROMEN-2-ONE
Diseases
GWAS			Crohn's disease ( 21102463)
Protein-Protein Interactions		9 interactors: ESRRA HIST1H3A HIST1H4A HIST3H3 HIST4H4 MDC1 PRKACA RTN1 RUNX1T1	34 interactors: ADH5 ATXN1 DPF1 DPF2 DPF3 DUT EIF3I ESR1 ESRRG EXOSC6 FUS GTF2B HDAC8 KAT2B LYST MACF1 MAP2K5 NCOA1 NCOA3 NR0B1 NR0B2 NRIP1 NSD1 NXF1 PIAS4 PNRC2 PPARGC1A PRKCD PROX1 SIRT1 SMARCD3 SP1 SRC TNNI2
Entrez ID		55869	2101
HPRD ID		02227	07210
Ensembl ID		ENSG00000147099	ENSG00000173153
Uniprot IDs		Q9BY41	P11474 Q569H8
PDB IDs		1T64 1T67 1T69 1VKG 1W22 2V5W 2V5X 3EW8 3EWF 3EZP 3EZT 3F06 3F07 3F0R 3MZ3 3MZ4 3MZ6 3MZ7 3RQD 3SFF 3SFH	1XB7 2PJL 3D24 3K6P
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Nucleosome Assembly DNA Methylation On Cytosine Chromatin Silencing At RDNA Chromatin Silencing Regulation Of Myeloid Cell Differentiation Histone H4-K20 Demethylation DNA Methylation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance DNA Modification Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Gene Silencing Nucleosome Assembly Chromatin Assembly Chromosome Organization Nucleosome Organization DNA Metabolic Process Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Regulation Of Megakaryocyte Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein-DNA Complex Assembly Negative Regulation Of Cellular Metabolic Process DNA Packaging CENP-A Containing Nucleosome Assembly Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange DNA Replication-independent Nucleosome Assembly Histone Lysine Demethylation Histone Demethylation Chromatin Organization Protein Demethylation Mitotic Cell Cycle DNA Conformation Change Centromere Complex Assembly Nucleobase-containing Compound Metabolic Process Demethylation ATP-dependent Chromatin Remodeling Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Modification Positive Regulation Of Dense Core Granule Biogenesis Methylation Cellular Nitrogen Compound Metabolic Process	Gene Expression Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Intracellular Receptor Signaling Pathway Biosynthetic Process Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Regulation Of Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Chromatin Modification Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Androgen Receptor Signaling Pathway Reproductive Structure Development Negative Regulation Of Cellular Metabolic Process Reproductive System Development Chromatin Organization Response To Hormone
Tagcloud ?		activator acylthiourea anticancer calorimetric conformed cooperative deacetylase derivative detailed discriminatory encoded feature insight isothermal isozyme kinetic kinetics malignancy mechanistic modeling neuroblastoma served sh steady sy5y thermodynamics titration tm wherein	biogenesis constituent coregulated ctf1 dap3 elk1 elk4 exploring gabpa gtp hdap3 homoeostasis hox11 microarray mitochondrial nrf oncocytic pparg presenting publicly ribosome runx1 rxra silico tal1 ternary tumourigenesis tumours upregulated
Tagcloud (Difference) ?		activator acylthiourea anticancer calorimetric conformed cooperative deacetylase derivative detailed discriminatory encoded feature insight isothermal isozyme kinetic kinetics malignancy mechanistic modeling neuroblastoma served sh steady sy5y thermodynamics titration tm wherein	biogenesis constituent coregulated ctf1 dap3 elk1 elk4 exploring gabpa gtp hdap3 homoeostasis hox11 microarray mitochondrial nrf oncocytic pparg presenting publicly ribosome runx1 rxra silico tal1 ternary tumourigenesis tumours upregulated
Tagcloud (Intersection) ?