HDAC8 and ESRRA

Number of citations of the paper that reports this interaction (PubMedID 20484414)
41

Data Source:
BioGRID (enzymatic study)

		HDAC8	ESRRA
Description		histone deacetylase 8	estrogen related receptor alpha
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm	Chromatin Fibrillar Center Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton Intercellular Bridge
	Molecular Function	Histone Deacetylase Activity Protein Binding Hydrolase Activity Hsp70 Protein Binding Protein Lysine Deacetylase Activity Metal Ion Binding Hsp90 Protein Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Decrotonylase Activity Histone Decrotonylase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Estrogen Response Element Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Mitotic Sister Chromatid Cohesion Negative Regulation Of Protein Ubiquitination Heterochromatin Formation Regulation Of Protein Stability Regulation Of Telomere Maintenance	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway	PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity
Drugs		Valproic acid Decitabine Iron Zinc Vorinostat Vorinostat 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-Thienyl]Sulfonyl}Amino)Benzamide Trichostatin A Belinostat Romidepsin Panobinostat Phenylbutyric acid (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide 5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4'-HYDROXYAMIDE Coumarin 120 Entinostat Abexinostat Givinostat Pyroxamide Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Zinc chloride Zinc sulfate, unspecified form	Troglitazone Diethylstilbestrol Genistein Afimoxifene beta-Naphthoflavone 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE Flavone
Diseases
GWAS		Autism spectrum disorder ( 34069769) Chloride levels ( 29403010) Sodium levels ( 29403010)	Crohn's disease ( 21102463 28067908) Vitiligo ( 27723757)
Interacting Genes		9 interacting genes: ESRRA H3-4 H3C1 H4C1 H4C16 MDC1 PRKACA RTN1 RUNX1T1	37 interacting genes: ADH5 ATXN1 DUT ESR1 ESRRG EXOSC6 FAM9A FUS GTF2B HDAC8 HIF1A KAT2B LYST MACF1 MAP2K5 NCOA1 NCOA2 NCOA3 NR0B1 NR0B2 NRIP1 NSD1 NXF1 PIAS4 PNRC2 PPARG PPARGC1A PRKCD PROX1 PSMC5 REL RNF4 RXRA SIRT1 SMARCD3 SP1 TNNI2
Entrez ID		55869	2101
HPRD ID		02227	07210
Ensembl ID		ENSG00000147099	ENSG00000173153
Uniprot IDs		A0A3B3IS68 A0A3B3ISS7 A0A3B3IT30 A0A3B3IU01 A6NFW1 Q9BY41	P11474 Q569H8
PDB IDs		1T64 1T67 1T69 1VKG 1W22 2V5W 2V5X 3EW8 3EWF 3EZP 3EZT 3F06 3F07 3F0R 3MZ3 3MZ4 3MZ6 3MZ7 3RQD 3SFF 3SFH 4QA0 4QA1 4QA2 4QA3 4QA4 4QA5 4QA6 4QA7 4RN0 4RN1 4RN2 5BWZ 5D1B 5D1C 5D1D 5DC5 5DC6 5DC7 5DC8 5FCW 5THS 5THT 5THU 5THV 5VI6 6HSK 6ODA 6ODB 6ODC 7JVU 7JVV 7JVW	1XB7 2PJL 3D24 3K6P 7E2E
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Nucleosome Organization Protein-DNA Complex Assembly Chromosome Protein Heterodimerization Activity Protein Localization To Chromosome Chromatin Organization Telomere Organization CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Nucleoplasm Chromosome, Telomeric Region Regulation Of Megakaryocyte Differentiation DNA Binding Protein Localization To Organelle Protein-containing Complex Assembly Protein Localization To Chromosome, Centromeric Region Chromatin Remodeling Protein Localization To Chromatin Protein-containing Complex Organization Cellular Component Assembly Regulation Of Cell Differentiation Chromosome Organization Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Extracellular Exosome Spermatogonial Cell Division Nucleus CAMP-dependent Protein Kinase Activity Endoplasmic Reticulum Tubular Network Formation	Nuclear Receptor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Nucleoplasm Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Positive Regulation Of Metabolic Process Transcription Coregulator Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of RNA Metabolic Process Nuclear Retinoid X Receptor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Adipose Tissue Development Negative Regulation Of Metabolic Process Regulation Of Lipid Metabolic Process Transcription Coregulator Binding Nuclear Retinoic Acid Receptor Binding DNA Binding Domain Binding Regulation Of Adipose Tissue Development Retinoic Acid Receptor Signaling Pathway Transcription By RNA Polymerase II Protein-lysine-acetyltransferase Activity LBD Domain Binding Circadian Regulation Of Gene Expression
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