GTF2IRD1 and PIAS2

Number of citations of the paper that reports this interaction (PubMedID 12193603)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		GTF2IRD1	PIAS2
Description		GTF2I repeat domain containing 1	protein inhibitor of activated STAT 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Chromatin Nucleus Nucleoplasm PML Body Nuclear Speck
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Transition Between Slow And Fast Fiber	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Protein Sumoylation Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process SMAD Protein Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways			Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Age at suicide ( 31476763) Aluminium levels ( 26025379) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Rheumatoid arthritis ( 32723749) Severe influenza A (H1N1) infection ( 26379185) Sjögren's syndrome ( 24097066) Systemic lupus erythematosus ( 26663301 28714469) Triglyceride levels ( 32203549)	Fruit consumption ( 32066663)
Interacting Genes		24 interacting genes: ALMS1 ATP2C1 CDK20 DCAF6 EXOSC4 GORASP2 HDAC3 HTRA4 KPNA1 KPNA2 KPNA3 KPNA4 MRFAP1L1 PIAS1 PIAS2 PIP4P2 PKP1 PKP2 SELENOS SMAD3 SPTLC1 UBC USP20 ZMYM5	128 interacting genes: - ACY3 ADA AKT1 AR ATF2 C1QA C5orf24 CBS CCHCR1 CCNDBP1 CDCA8 CGGBP1 CHMP4B CLDN2 CREB1 CREBBP CTBP1 DDX39B DES DEUP1 DMC1 DNMT3A EDC3 ELK1 ESR1 ESR2 EXOSC8 FAM118B FKBP6 FLI1 GFAP GLUL GOLGA2 GRHL2 GRM8 GTF2I GTF2IRD1 HDAC3 HMBOX1 HMG20A HMG20B HMGXB4 HNRNPCL1 HNRNPUL1 HOMER1 HOOK1 HUWE1 IKZF1 IMPDH1 JUN KIFC3 LCE1E LCE2C LMNA LMNB1 MAPK14 MAPK8 MAPKAPK2 MBD1 MITF MLX MSX2 MX1 MX2 NAV2 NME7 NR3C1 PAICS PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 PRKRA PRPH RFX2 RUFY1 RUNX1T1 SEC23A SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SOX5 SPATC1L SPINDOC SREBF2 STAT1 STAT4 STIP1 SUMO1 SUMO1P1 SUMO2 SUMO3 SYN3 TH TICAM2 TP53 TRAF2 TRAF3 TRAF5 TRIM23 TRIM27 TRIM50 TRIM55 TRIM63 TSR2 TXLNA UBASH3B UBE2I UBE2L3 UBQLN1 ZBED1 ZBTB16 ZBTB8A ZC3H10 ZFP42 ZNF319 ZNF451 ZNRD2
Entrez ID		9569	9063
HPRD ID		08379	06944
Ensembl ID		ENSG00000006704	ENSG00000078043
Uniprot IDs		E9PFE2 Q9UHL9	O75928 Q2TA77
PDB IDs		2D99 2DN5 2DZQ 2DZR	2ASQ 4FO9
Enriched GO Terms of Interacting Partners?		NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Viral Penetration Into Host Nucleus Protein Import Into Nucleus Import Into Nucleus Intermediate Filament Binding Intracellular Transport Of Virus Intermediate Filament Bundle Assembly Desmosome Assembly Nucleoplasm Host Cell Protein Localization To Nucleus SUMO Ligase Activity Positive Regulation Of Protein Localization To Cell Periphery Desmosome Organization Nuclear Pore Ubiquitin-specific Protease Binding Positive Regulation Of Protein Localization SUMO Transferase Activity Nuclear Transport Nucleocytoplasmic Transport SMAD Protein Signal Transduction Desmosome Ubiquitin Protein Ligase Binding Intracellular Protein Transport Cellular Localization Collagen Type XV Trimer Establishment Of Protein Localization To Organelle Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Cell Periphery Maintenance Of Protein Localization At Cell Tip Positive Regulation Of Ferroptosis	Identical Protein Binding Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of RNA Biosynthetic Process PML Body Protein Sumoylation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Protein Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific SUMO Transferase Activity Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Positive Regulation Of Biosynthetic Process Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Estrogen Response Element Binding Sequence-specific DNA Binding Positive Regulation Of Metabolic Process
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