GTF2IRD1 and DCAF6

Number of citations of the paper that reports this interaction (PubMedID 26275350)
0

Data Source:
BioGRID (two hybrid)

		GTF2IRD1	DCAF6
Description		GTF2I repeat domain containing 1	DDB1 and CUL4 associated factor 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Transcription Coactivator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Transition Between Slow And Fast Fiber	Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Neddylation
Drugs
Diseases
GWAS		Age at suicide ( 31476763) Aluminium levels ( 26025379) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Rheumatoid arthritis ( 32723749) Severe influenza A (H1N1) infection ( 26379185) Sjögren's syndrome ( 24097066) Systemic lupus erythematosus ( 26663301 28714469) Triglyceride levels ( 32203549)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Schizophrenia ( 22037555)
Interacting Genes		24 interacting genes: ALMS1 ATP2C1 CDK20 DCAF6 EXOSC4 GORASP2 HDAC3 HTRA4 KPNA1 KPNA2 KPNA3 KPNA4 MRFAP1L1 PIAS1 PIAS2 PIP4P2 PKP1 PKP2 SELENOS SMAD3 SPTLC1 UBC USP20 ZMYM5	14 interacting genes: ACVR1 AR BMPR1B CLIP4 CTBP1 CTBP2 DSCR9 GTF2IRD1 NR3C1 SMAD2 SUPT5H TGFBR1 TRIM55 TRIM63
Entrez ID		9569	55827
HPRD ID		08379	17156
Ensembl ID		ENSG00000006704	ENSG00000143164
Uniprot IDs		E9PFE2 Q9UHL9	Q58WW2
PDB IDs		2D99 2DN5 2DZQ 2DZR	3I7O
Enriched GO Terms of Interacting Partners?		NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Viral Penetration Into Host Nucleus Protein Import Into Nucleus Import Into Nucleus Intermediate Filament Binding Intracellular Transport Of Virus Intermediate Filament Bundle Assembly Desmosome Assembly Nucleoplasm Host Cell Protein Localization To Nucleus SUMO Ligase Activity Positive Regulation Of Protein Localization To Cell Periphery Desmosome Organization Nuclear Pore Ubiquitin-specific Protease Binding Positive Regulation Of Protein Localization SUMO Transferase Activity Nuclear Transport Nucleocytoplasmic Transport SMAD Protein Signal Transduction Desmosome Ubiquitin Protein Ligase Binding Intracellular Protein Transport Cellular Localization Collagen Type XV Trimer Establishment Of Protein Localization To Organelle Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Cell Periphery Maintenance Of Protein Localization At Cell Tip Positive Regulation Of Ferroptosis	Transforming Growth Factor Beta Receptor Activity, Type I SMAD Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Activin Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Response To Growth Factor Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Receptor Complex Activin Receptor Activity, Type I Tissue Morphogenesis Trophoblast Cell Migration Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition BMP Receptor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Transcription By RNA Polymerase II Response To Transforming Growth Factor Beta Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Activin Binding Positive Regulation Of Macromolecule Biosynthetic Process Estrogen Response Element Binding In Utero Embryonic Development Chordate Embryonic Development Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regionalization Negative Regulation Of RNA Metabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway White Fat Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Pharyngeal System Development Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction
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