GTF2IRD1 and COL15A1

Data Source: HiPPIP (Novel)

		GTF2IRD1	COL15A1
Name		GTF2I repeat domain containing 1	collagen type XV alpha 1 chain
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Extracellular Region Collagen Trimer Collagen Type XV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Transition Between Slow And Fast Fiber	Angiogenesis Cell Adhesion Signal Transduction Cell Differentiation
Pathways		None	Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Collagen chain trimerization
GWAS		Age at suicide ( 31476763 ) Aluminium levels ( 26025379 ) General factor of neuroticism ( 30867560 ) Neuroticism ( 29255261 ) Rheumatoid arthritis ( 32723749 ) Severe influenza A (H1N1) infection ( 26379185 ) Sjögren's syndrome ( 24097066 ) Systemic lupus erythematosus ( 26663301 28714469 ) Triglyceride levels ( 32203549 )	Advanced age-related macular degeneration ( 26691988 ) Appendicular lean mass ( 33097823 ) Asthma ( 32296059 31959851 ) Blood protein levels ( 30072576 ) Brain morphology (MOSTest) ( 32665545 ) Chronic obstructive pulmonary disease ( 30804561 ) Epithelial ovarian cancer ( 25134534 ) Fractures (paediatric) ( 32742401 ) Gut microbiota alpha diversity (Shannon index) ( 33208821 ) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821 ) Height ( 28552196 ) Lateral ventricle temporal horn volume ( 31530798 ) Pulse pressure ( 30224653 30578418 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		1 novel interactors: COL15A1	6 novel interactors: GAS1 GOLGA5 GTF2IRD1 MYO9A PDGFB PIGO
Interacting Genes		24 interacting genes: ALMS1 ATP2C1 CDK20 DCAF6 EXOSC4 GORASP2 HDAC3 HTRA4 KPNA1 KPNA2 KPNA3 KPNA4 MRFAP1L1 PIAS1 PIAS2 PIP4P2 PKP1 PKP2 SELENOS SMAD3 SPTLC1 UBC USP20 ZMYM5	None recorded
Entrez ID		9569	1306
HPRD ID		08379	00380
Ensembl ID		ENSG00000006704	ENSG00000204291
Uniprot IDs		E9PFE2 Q9UHL9	B3KTP7 P39059
PDB IDs		2D99 2DN5 2DZQ 2DZR	3N3F
GO Terms Enriched among Interactors		NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Viral Penetration Into Host Nucleus Protein Import Into Nucleus Import Into Nucleus Intermediate Filament Binding Intracellular Transport Of Virus Intermediate Filament Bundle Assembly Desmosome Assembly Nucleoplasm Host Cell Protein Localization To Nucleus SUMO Ligase Activity Positive Regulation Of Protein Localization To Cell Periphery Desmosome Organization Nuclear Pore Ubiquitin-specific Protease Binding Positive Regulation Of Protein Localization SUMO Transferase Activity Nuclear Transport Nucleocytoplasmic Transport SMAD Protein Signal Transduction Desmosome Ubiquitin Protein Ligase Binding Intracellular Protein Transport Cellular Localization Collagen Type XV Trimer Establishment Of Protein Localization To Organelle Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Cell Periphery Maintenance Of Protein Localization At Cell Tip Positive Regulation Of Ferroptosis	Positive Regulation Of Metanephric Mesenchymal Cell Migration Cellular Response To Mycophenolic Acid Metanephric Glomerular Mesangial Cell Development Platelet-derived Growth Factor Complex Positive Regulation Of Glomerular Filtration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Negative Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Transition Between Slow And Fast Fiber Mannose-ethanolamine Phosphotransferase Activity Glomerular Mesangial Cell Development Unconventional Myosin Complex Smooth Muscle Adaptation Negative Regulation Of Phospholipid Biosynthetic Process Regulation Of Hyaluronan Biosynthetic Process Mesangial Cell Development Positive Regulation Of Glomerular Mesangial Cell Proliferation Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Protein Autophosphorylation Paracrine Signaling Cellular Response To Growth Factor Stimulus Regulation Of ER To Golgi Vesicle-mediated Transport Platelet-derived Growth Factor Binding Regulation Of Glomerular Mesangial Cell Proliferation Platelet-derived Growth Factor Receptor-beta Signaling Pathway Superoxide-generating NADPH Oxidase Activator Activity Positive Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Glomerular Filtration Regulation Of Skeletal Muscle Adaptation Golgi Cisterna Retrograde Transport, Vesicle Recycling Within Golgi Phosphotransferase Activity, For Other Substituted Phosphate Groups Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation