GTF2IRD1

Name	GTF2I repeat domain containing 1
Structure
Novel Interactors	1 novel interactors: COL15A1
Interactors	24 interactors: ALMS1 ATP2C1 CDK20 DCAF6 EXOSC4 GORASP2 HDAC3 HTRA4 KPNA1 KPNA2 KPNA3 KPNA4 MRFAP1L1 PIAS1 PIAS2 PIP4P2 PKP1 PKP2 SELENOS SMAD3 SPTLC1 UBC USP20 ZMYM5
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Transition Between Slow And Fast Fiber
GWAS	Age at suicide ( 31476763 ) Aluminium levels ( 26025379 ) General factor of neuroticism ( 30867560 ) Neuroticism ( 29255261 ) Rheumatoid arthritis ( 32723749 ) Severe influenza A (H1N1) infection ( 26379185 ) Sjögren's syndrome ( 24097066 ) Systemic lupus erythematosus ( 26663301 28714469 ) Triglyceride levels ( 32203549 )
Entrez ID	9569
HPRD ID	08379
Ensembl ID	ENSG00000006704
Uniprot IDs	E9PFE2 Q9UHL9
PDB IDs	2D99 2DN5 2DZQ 2DZR
GO Terms Enriched among Interactors ?	NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Viral Penetration Into Host Nucleus Protein Import Into Nucleus Import Into Nucleus Intermediate Filament Binding Intracellular Transport Of Virus Intermediate Filament Bundle Assembly Desmosome Assembly Nucleoplasm Host Cell Protein Localization To Nucleus SUMO Ligase Activity Positive Regulation Of Protein Localization To Cell Periphery Desmosome Organization Nuclear Pore Ubiquitin-specific Protease Binding Positive Regulation Of Protein Localization SUMO Transferase Activity Nuclear Transport Nucleocytoplasmic Transport SMAD Protein Signal Transduction Desmosome Ubiquitin Protein Ligase Binding Intracellular Protein Transport Cellular Localization Collagen Type XV Trimer Establishment Of Protein Localization To Organelle Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Cell Periphery Maintenance Of Protein Localization At Cell Tip Positive Regulation Of Ferroptosis