FES

Name	FES proto-oncogene, tyrosine kinase
Structure
Novel Interactors	10 novel interactors: ALDH1B1 BLM CBX5 FURIN MAN2A2 NLGN4X PEX11A STARD5 VANGL1 ZNF117
Interactors	40 interactors: APP AR BCAR1 BCR CSF2RB DOK1 DPYSL5 EGFR ERBB2 ERBB3 ERBB4 FKBP4 FKBP5 GAB1 HSH2D HSPA4 IL4R IRS1 IRS2 JAK1 JAK2 JAK3 KIT MDFI MET NEDD4 PDE4DIP PIK3R1 PLXNA1 POT1 PPID PTGES3 RASA1 RASA3 SMURF1 STAT3 TERF1 TRIM28 ZNF746 ZNF775
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cytoplasmic Side Of Plasma Membrane Microtubule Cytoskeleton Membrane Cytoplasmic Vesicle Anchoring Junction
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Microtubule Binding Lipid Binding Kinase Activity Transferase Activity Immunoglobulin Receptor Binding Phosphatidylinositol Binding
	Biological Process	Microtubule Bundle Formation Chemotaxis Centrosome Cycle Cell Adhesion Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Microtubule Polymerization Positive Regulation Of Protein Polymerization Regulation Of Cell Population Proliferation Regulation Of Mast Cell Degranulation Regulation Of Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Monocyte Differentiation Protein Autophosphorylation Myoblast Proliferation Positive Regulation Of Cytoskeleton Organization Cardiac Muscle Cell Proliferation Regulation Of Vesicle-mediated Transport Cellular Response To Vitamin D Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Motility
Pathways	Signaling by SCF-KIT Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling
Drugs	Fostamatinib
GWAS	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Appendicular lean mass ( 33097823 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Birth weight ( 31043758 27680694 ) Blood pressure ( 21909110 ) Brain morphology (MOSTest) ( 32665545 ) Caffeine consumption from coffee ( 33287642 ) Coffee consumption ( 31046077 ) Coronary artery disease ( 29212778 32469254 26343387 33020668 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Daytime sleep phenotypes ( 27126917 ) Diastolic blood pressure ( 28739976 21909115 27841878 27618452 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Hypertension ( 21909115 31879980 ) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (beta blocking agents) ( 31015401 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Myocardial infarction ( 33532862 26343387 ) Number of sexual partners ( 30643258 ) Offspring birth weight ( 31043758 ) Parental lifespan ( 30642433 ) Pulse pressure ( 27841878 30578418 ) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962 ) Schizophrenia ( 30285260 25056061 29483656 ) Systolic blood pressure ( 27841878 30578418 27618452 28135244 26390057 28739976 21909115 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 )
Entrez ID	2242
HPRD ID	01814
Ensembl ID	ENSG00000182511
Uniprot IDs	P07332
PDB IDs	1WQU 2DCR 3BKB 3CBL 3CD3 4DYL 4E93 6JMF 7T1K 7T1L 8X2T 8XKP
GO Terms Enriched among Interactors ?	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Receptor Complex Intracellular Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Growth Hormone Receptor Signaling Pathway Protein Phosphatase Binding Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Via JAK-STAT ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Phosphatidylinositol 3-kinase Binding Protein-containing Complex ErbB-3 Class Receptor Binding Cytokine-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin Receptor Binding ERBB2 Signaling Pathway Regulation Of Signal Transduction Interleukin-4-mediated Signaling Pathway Cell Differentiation Negative Regulation Of Programmed Cell Death Interleukin-9-mediated Signaling Pathway Regulation Of Protein Localization Basal Plasma Membrane Protein Kinase Activity Positive Regulation Of Epithelial Cell Proliferation Telomeric D-loop Disassembly Cytosol Regulation Of Cellular Component Organization Cell Activation T Cell Activation Regulation Of Programmed Cell Death Insulin-like Growth Factor Receptor Signaling Pathway Growth Hormone Receptor Binding Interleukin-15-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Migration Insulin Receptor Signaling Pathway Telomeric Loop Disassembly Positive Regulation Of Cell Migration Leukocyte Activation Positive Regulation Of Protein Localization