FES and FKBP5

Number of citations of the paper that reports this interaction (PubMedID 9222609)
0

Data Source:
BioGRID (pull down)

		FES	FKBP5
Description		FES proto-oncogene, tyrosine kinase	FKBP prolyl isomerase 5
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cytoplasmic Side Of Plasma Membrane Microtubule Cytoskeleton Membrane Cytoplasmic Vesicle Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Microtubule Binding Lipid Binding Kinase Activity Transferase Activity Immunoglobulin Receptor Binding Phosphatidylinositol Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Isomerase Activity Protein-macromolecule Adaptor Activity Heat Shock Protein Binding
	Biological Process	Microtubule Bundle Formation Chemotaxis Centrosome Cycle Cell Adhesion Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Microtubule Polymerization Positive Regulation Of Protein Polymerization Regulation Of Cell Population Proliferation Regulation Of Mast Cell Degranulation Regulation Of Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Monocyte Differentiation Protein Autophosphorylation Myoblast Proliferation Positive Regulation Of Cytoskeleton Organization Cardiac Muscle Cell Proliferation Regulation Of Vesicle-mediated Transport Cellular Response To Vitamin D Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Motility	Protein Folding Response To Bacterium Response To Cocaine Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Alcohol
Pathways		Signaling by SCF-KIT Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand ESR-mediated signaling MECP2 regulates neuronal receptors and channels Modulation of host responses by IFN-stimulated genes
Drugs		Fostamatinib
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Birth weight ( 31043758 27680694) Blood pressure ( 21909110) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from coffee ( 33287642) Coffee consumption ( 31046077) Coronary artery disease ( 29212778 32469254 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 28739976 21909115 27841878 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Hypertension ( 21909115 31879980) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862 26343387) Number of sexual partners ( 30643258) Offspring birth weight ( 31043758) Parental lifespan ( 30642433) Pulse pressure ( 27841878 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Schizophrenia ( 30285260 25056061 29483656) Systolic blood pressure ( 27841878 30578418 27618452 28135244 26390057 28739976 21909115) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)	A body shape index ( 34021172) Autoimmune thyroid disease ( 32581359) Birth weight ( 31043758) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Eosinophil count ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Offspring birth weight ( 31043758) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 27863252)
Interacting Genes		40 interacting genes: APP AR BCAR1 BCR CSF2RB DOK1 DPYSL5 EGFR ERBB2 ERBB3 ERBB4 FKBP4 FKBP5 GAB1 HSH2D HSPA4 IL4R IRS1 IRS2 JAK1 JAK2 JAK3 KIT MDFI MET NEDD4 PDE4DIP PIK3R1 PLXNA1 POT1 PPID PTGES3 RASA1 RASA3 SMURF1 STAT3 TERF1 TRIM28 ZNF746 ZNF775	13 interacting genes: APP CEBPA CHUK ESR1 FES HSF1 HSP90AA1 IKBKE MCMBP NR2C2 OGT PGR STIP1
Entrez ID		2242	2289
HPRD ID		01814	04019
Ensembl ID		ENSG00000182511	ENSG00000096060
Uniprot IDs		P07332	Q13451 Q2TA84
PDB IDs		1WQU 2DCR 3BKB 3CBL 3CD3 4DYL 4E93 6JMF 7T1K 7T1L 8X2T 8XKP	1KT0 3O5D 3O5E 3O5F 3O5G 3O5I 3O5J 3O5K 3O5L 3O5M 3O5O 3O5P 3O5Q 3O5R 4DRH 4DRI 4DRK 4DRM 4DRN 4DRO 4DRP 4DRQ 4JFI 4JFJ 4JFK 4JFL 4JFM 4R0X 4TW6 4TW7 4TX0 4W9O 4W9P 4W9Q 5BXJ 5DIT 5DIU 5DIV 5NJX 5OBK 5OMP 6SAF 6TX4 6TX5 6TX6 6TX7 6TX8 6TX9 6TXX 7A6W 7A6X 7AOT 7AOU 7APQ 7APS 7APT 7APW 7AWF 7AWX 7B9Y 7B9Z 7BA0 7ETT 7ETU 7ETV 7L7I 7R0L 8BA6 8BAJ 8CCA 8CCB 8CCC 8CCD 8CCE 8CCF 8CCG 8CCH 8CHN 8CHP 8CHQ 8CHR 8FFW 8PC2 8PJ8 8PJA 8R5K 9EU6 9EU7 9EU8 9EU9 9EUA 9EUB 9EUC 9EUD 9EUE 9EY3 9EY4 9GPK 9GPL 9GPM 9GPN 9GPO 9GPP 9GPQ 9GPR 9GPS 9GPT 9GPU 9GPV 9GPW 9GPX 9GPY 9GPZ 9GQ2 9GQ3 9GQ4 9GQ5 9GQ6 9GQ7 9GQ8 9GQ9 9GQA 9GQB 9GQC 9GQD 9GQE 9GQF 9GQG 9GQH 9GQI 9GQJ 9GQK
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Receptor Complex Intracellular Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Growth Hormone Receptor Signaling Pathway Protein Phosphatase Binding Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Via JAK-STAT ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Phosphatidylinositol 3-kinase Binding Protein-containing Complex ErbB-3 Class Receptor Binding Cytokine-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin Receptor Binding ERBB2 Signaling Pathway Regulation Of Signal Transduction Interleukin-4-mediated Signaling Pathway Cell Differentiation Negative Regulation Of Programmed Cell Death Interleukin-9-mediated Signaling Pathway Regulation Of Protein Localization Basal Plasma Membrane Protein Kinase Activity Positive Regulation Of Epithelial Cell Proliferation Telomeric D-loop Disassembly Cytosol Regulation Of Cellular Component Organization Cell Activation T Cell Activation Regulation Of Programmed Cell Death Insulin-like Growth Factor Receptor Signaling Pathway Growth Hormone Receptor Binding Interleukin-15-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Migration Insulin Receptor Signaling Pathway Telomeric Loop Disassembly Positive Regulation Of Cell Migration Leukocyte Activation Positive Regulation Of Protein Localization	Intracellular Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Protein-containing Complex Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Response To Peptide Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process IkappaB Kinase Activity Protein Folding Chaperone Complex Positive Regulation Of Immune System Process Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Hormone Positive Regulation Of Nitric Oxide Metabolic Process Response To Nutrient Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nuclear Receptor Activity Regulation Of Protein-containing Complex Assembly DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Defense Response Regulation Of Nitric Oxide Metabolic Process Sequence-specific DNA Binding Nitric-oxide Synthase Regulator Activity Regulation Of Defense Response Positive Regulation Of Metabolic Process Chromatin Binding Cellular Response To Virus Negative Regulation Of RNA Metabolic Process STAT Family Protein Binding Estrogen Response Element Binding Regulation Of Nucleobase-containing Compound Metabolic Process Response To Cytokine Chromatin DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Type I Interferon Production Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Xenobiotic Stimulus Nucleus Nucleoplasm Regulation Of Canonical NF-kappaB Signal Transduction DNA-binding Transcription Factor Activity Lipid Binding
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