FES and GAB1

Number of citations of the paper that reports this interaction (PubMedID 24728074)
77

Data Source:
BioGRID (pull down)

		FES	GAB1
Description		FES proto-oncogene, tyrosine kinase	GRB2 associated binding protein 1
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cytoplasmic Side Of Plasma Membrane Microtubule Cytoskeleton Membrane Cytoplasmic Vesicle Anchoring Junction	Cytoplasm Cytosol Cell-cell Junction
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Microtubule Binding Lipid Binding Kinase Activity Transferase Activity Immunoglobulin Receptor Binding Phosphatidylinositol Binding	Protein Binding Signaling Adaptor Activity
	Biological Process	Microtubule Bundle Formation Chemotaxis Centrosome Cycle Cell Adhesion Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Microtubule Polymerization Positive Regulation Of Protein Polymerization Regulation Of Cell Population Proliferation Regulation Of Mast Cell Degranulation Regulation Of Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Monocyte Differentiation Protein Autophosphorylation Myoblast Proliferation Positive Regulation Of Cytoskeleton Organization Cardiac Muscle Cell Proliferation Regulation Of Vesicle-mediated Transport Cellular Response To Vitamin D Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Motility	Angiogenesis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Intracellular Signal Transduction Endothelial Cell Chemotaxis Vascular Endothelial Growth Factor Signaling Pathway Vasodilation Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Mechanical Stimulus
Pathways		Signaling by SCF-KIT Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling	PI3K Cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PIP3 activates AKT signaling GAB1 signalosome PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling RET signaling MET activates PTPN11 MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants
Drugs		Fostamatinib
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Birth weight ( 31043758 27680694) Blood pressure ( 21909110) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from coffee ( 33287642) Coffee consumption ( 31046077) Coronary artery disease ( 29212778 32469254 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 28739976 21909115 27841878 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Hypertension ( 21909115 31879980) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862 26343387) Number of sexual partners ( 30643258) Offspring birth weight ( 31043758) Parental lifespan ( 30642433) Pulse pressure ( 27841878 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Schizophrenia ( 30285260 25056061 29483656) Systolic blood pressure ( 27841878 30578418 27618452 28135244 26390057 28739976 21909115) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)	Asthma ( 21804548) Diastolic blood pressure ( 27841878) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate in non-diabetics ( 31451708) Height ( 31562340) Malaria ( 31844061) Systolic blood pressure ( 27841878) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		40 interacting genes: APP AR BCAR1 BCR CSF2RB DOK1 DPYSL5 EGFR ERBB2 ERBB3 ERBB4 FKBP4 FKBP5 GAB1 HSH2D HSPA4 IL4R IRS1 IRS2 JAK1 JAK2 JAK3 KIT MDFI MET NEDD4 PDE4DIP PIK3R1 PLXNA1 POT1 PPID PTGES3 RASA1 RASA3 SMURF1 STAT3 TERF1 TRIM28 ZNF746 ZNF775	74 interacting genes: AKT1 ARHGAP32 BCAR3 BLK BLNK BTK C1QBP CRK CRKL EGFR EPOR ERBB2 FCGR2B FES FRS2 GAB2 GRAP2 GRB2 GTF2A1L HCK HSH2D INPP5D INPPL1 INSR ITK JAK1 LAT2 MAP3K3 MAPK1 MAPK3 MAPK4 MARK2 MET MST1R NCK1 NCK2 PDGFRB PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PTK6 PTPN11 PTPN18 RASA1 RET SH2D1B SH2D2A SH2D3A SHC1 SHC3 SLA SLA2 SOCS3 SOCS6 SOS1 SRC STAP1 SUPT6H SYK SYP TEC TNS1 TNS3 TNS4 TRIM15 VAV1 VAV2 VAV3 WEE2-AS1 YAP1 YES1
Entrez ID		2242	2549
HPRD ID		01814	05116
Ensembl ID		ENSG00000182511	ENSG00000109458
Uniprot IDs		P07332	B7Z3B9 Q13480 Q9HA84
PDB IDs		1WQU 2DCR 3BKB 3CBL 3CD3 4DYL 4E93 6JMF 7T1K 7T1L 8X2T 8XKP	4QSY
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Receptor Complex Intracellular Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Growth Hormone Receptor Signaling Pathway Protein Phosphatase Binding Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Via JAK-STAT ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Phosphatidylinositol 3-kinase Binding Protein-containing Complex ErbB-3 Class Receptor Binding Cytokine-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin Receptor Binding ERBB2 Signaling Pathway Regulation Of Signal Transduction Interleukin-4-mediated Signaling Pathway Cell Differentiation Negative Regulation Of Programmed Cell Death Interleukin-9-mediated Signaling Pathway Regulation Of Protein Localization Basal Plasma Membrane Protein Kinase Activity Positive Regulation Of Epithelial Cell Proliferation Telomeric D-loop Disassembly Cytosol Regulation Of Cellular Component Organization Cell Activation T Cell Activation Regulation Of Programmed Cell Death Insulin-like Growth Factor Receptor Signaling Pathway Growth Hormone Receptor Binding Interleukin-15-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Migration Insulin Receptor Signaling Pathway Telomeric Loop Disassembly Positive Regulation Of Cell Migration Leukocyte Activation Positive Regulation Of Protein Localization	Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Protein Tyrosine Kinase Activity Positive Regulation Of Immune System Process Regulation Of Immune System Process ERBB Signaling Pathway Intracellular Signaling Cassette Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Immune Response Protein Kinase Activity Regulation Of Signal Transduction Immune System Process Antigen Receptor-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Kinase Activity B Cell Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Cell Activation Regulation Of MAPK Cascade Non-membrane Spanning Protein Tyrosine Kinase Activity Leukocyte Activation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Cytosol Positive Regulation Of MAPK Cascade Lymphocyte Activation Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Cell Migration Phosphorylation Insulin Receptor Signaling Pathway Immune Effector Process Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Immune System Process Receptor Tyrosine Kinase Binding Regulation Of Cell Adhesion
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