FES and FKBP4

Number of citations of the paper that reports this interaction (PMID 9222609)
41

Data Source:
BioGRID (pull down)

		FES	FKBP4
Gene Name		FES proto-oncogene, tyrosine kinase	FK506 binding protein 4, 59kDa
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Microtubule Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Cytosol Microtubule Neuronal Cell Body Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Immunoglobulin Receptor Binding Phosphatidylinositol Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding ATP Binding GTP Binding FK506 Binding Protein Binding, Bridging Heat Shock Protein Binding Copper-dependent Protein Binding Glucocorticoid Receptor Binding Poly(A) RNA Binding Tau Protein Binding Phosphoprotein Binding
	Biological Process	Protein Phosphorylation Chemotaxis Epidermal Growth Factor Receptor Signaling Pathway Multicellular Organismal Development Axon Guidance Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Microtubule Polymerization Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Regulation Of Mast Cell Degranulation Innate Immune Response Regulation Of Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Protein Autophosphorylation Regulation Of Vesicle-mediated Transport Regulation Of Cell Motility Positive Regulation Of Actin Cytoskeleton Reorganization	Protein Peptidyl-prolyl Isomerization Protein Folding Steroid Hormone Receptor Complex Assembly Copper Ion Transport Embryo Implantation Negative Regulation Of Neuron Projection Development Androgen Receptor Signaling Pathway Prostate Gland Development Negative Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Protein Complex Localization Cellular Response To Heat Male Sex Differentiation Chaperone-mediated Protein Folding Regulation Of Cellular Response To Heat
Pathways		Signaling by SCF-KIT Axon guidance Semaphorin interactions Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling	HSF1-dependent transactivation Attenuation phase Cellular response to heat stress
Drugs
Diseases
GWAS		Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) Hypertension ( 21909115) Systolic blood pressure ( 21909115)	Quantitative traits ( 19197348)
Protein-Protein Interactions		31 interactors: BCAR1 BCR CSF2RB DOK1 DPYSL5 EGFR FKBP4 FKBP5 HSH2D HSPA4 IL4R IRS1 IRS2 JAK1 JAK2 JAK3 MDFI NEDD4 PDE4DIP PIK3R1 PLXNA1 POT1 PPID PTGES3 RASA1 RASA3 STAT3 TERF1 TRIM28 ZNF746 ZNF775	25 interactors: ACVR1 ATOX1 CALM1 CSNK2A1 EGFR ESR1 FES FKBP1A GLMN HSF1 HSP90AA1 HSPA4 IRF4 NR3C1 NR3C2 PHYH PTPN2 S100A1 S100A2 S100A6 SH3BP4 SMURF2 SNCA SQSTM1 STIP1
Entrez ID		2242	2288
HPRD ID		01814	11794
Ensembl ID		ENSG00000182511
Uniprot IDs		P07332	Q02790
PDB IDs		1WQU 2DCR 3BKB 3CBL 3CD3 4DYL 4E93	1N1A 1P5Q 1Q1C 1QZ2 4DRJ 4LAV 4LAW 4LAX
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Peptide JAK-STAT Cascade Positive Regulation Of Transport Intracellular Signal Transduction Cellular Response To Hormone Stimulus Regulation Of Cellular Localization Regulation Of Cell Migration Signal Transduction Regulation Of Protein Transport Regulation Of Cell Motility Regulation Of Immune Response Response To Peptide Hormone Cellular Response To Stimulus Response To Organic Substance Regulation Of Establishment Of Protein Localization Regulation Of Locomotion Response To Peptide Regulation Of Cellular Component Movement Response To Stimulus Response To Hormone Positive Regulation Of Protein Transport Cellular Response To Organic Substance Signaling Regulation Of Cell Death Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Nucleocytoplasmic Transport Neurotrophin TRK Receptor Signaling Pathway Cell Communication Neurotrophin Signaling Pathway Regulation Of Protein Localization Response To Organonitrogen Compound Response To Stress Cytokine-mediated Signaling Pathway Chaperone-mediated Protein Folding Insulin Receptor Signaling Pathway Protein Import Epidermal Growth Factor Receptor Signaling Pathway Peptidyl-amino Acid Modification ERBB Signaling Pathway Locomotion	Response To Organic Substance Cellular Response To Organic Substance Regulation Of Oxidoreductase Activity Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Response To Stimulus Regulation Of Nitric-oxide Synthase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Stimulus Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Response To Lipid Cellular Response To Growth Factor Stimulus Negative Regulation Of Signaling Response To Organic Cyclic Compound Response To Growth Factor Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phospholipase Activity Developmental Process System Development Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Cyclic Compound Signaling Regulation Of Signaling Regulation Of Immune System Process Cell Communication Defense Response Protein Import Into Mitochondrial Outer Membrane Response To Steroid Hormone Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Oxidoreductase Activity Response To Stress Regulation Of Cell Proliferation Positive Regulation Of Nitric Oxide Biosynthetic Process Multicellular Organismal Development Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Innate Immune Response Cellular Response To Glucocorticoid Stimulus Response To Glucocorticoid Anatomical Structure Development Cellular Response To Corticosteroid Stimulus Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Immune Response Response To Corticosteroid
Tagcloud ?		1d4 counterpart e1c3 electrophoretic epsilon germline heavy hela iepsilon immunoglobulin initiating irs jak1 jak3 lysates mediating mobility parental promotor pronounced radiolabeled reconstitution restored shift stat6 tyrosine undergo utilized utilizing
Tagcloud (Difference) ?		1d4 counterpart e1c3 electrophoretic epsilon germline heavy hela iepsilon immunoglobulin initiating irs jak1 jak3 lysates mediating mobility parental promotor pronounced radiolabeled reconstitution restored shift stat6 tyrosine undergo utilized utilizing
Tagcloud (Intersection) ?