FES and HSH2D

Number of citations of the paper that reports this interaction (PMID 11700021)
4

Data Source:
HPRD (two hybrid, in vivo)

		FES	HSH2D
Gene Name		FES proto-oncogene, tyrosine kinase	hematopoietic SH2 domain containing
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Microtubule Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle	Nucleus Mitochondrion Cytosol
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Immunoglobulin Receptor Binding Phosphatidylinositol Binding	SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Protein Phosphorylation Chemotaxis Epidermal Growth Factor Receptor Signaling Pathway Multicellular Organismal Development Axon Guidance Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Microtubule Polymerization Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Regulation Of Mast Cell Degranulation Innate Immune Response Regulation Of Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Protein Autophosphorylation Regulation Of Vesicle-mediated Transport Regulation Of Cell Motility Positive Regulation Of Actin Cytoskeleton Reorganization	Negative Regulation Of B Cell Apoptotic Process Positive Regulation Of Signal Transduction T Cell Activation Negative Regulation Of Mitochondrial Depolarization
Pathways		Signaling by SCF-KIT Axon guidance Semaphorin interactions Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) Hypertension ( 21909115) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		31 interactors: BCAR1 BCR CSF2RB DOK1 DPYSL5 EGFR FKBP4 FKBP5 HSH2D HSPA4 IL4R IRS1 IRS2 JAK1 JAK2 JAK3 MDFI NEDD4 PDE4DIP PIK3R1 PLXNA1 POT1 PPID PTGES3 RASA1 RASA3 STAT3 TERF1 TRIM28 ZNF746 ZNF775	3 interactors: FES MPP3 TNK2
Entrez ID		2242	84941
HPRD ID		01814	12219
Ensembl ID		ENSG00000182511	ENSG00000196684
Uniprot IDs		P07332	Q96JZ2
PDB IDs		1WQU 2DCR 3BKB 3CBL 3CD3 4DYL 4E93	2CS0
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Peptide JAK-STAT Cascade Positive Regulation Of Transport Intracellular Signal Transduction Cellular Response To Hormone Stimulus Regulation Of Cellular Localization Regulation Of Cell Migration Signal Transduction Regulation Of Protein Transport Regulation Of Cell Motility Regulation Of Immune Response Response To Peptide Hormone Cellular Response To Stimulus Response To Organic Substance Regulation Of Establishment Of Protein Localization Regulation Of Locomotion Response To Peptide Regulation Of Cellular Component Movement Response To Stimulus Response To Hormone Positive Regulation Of Protein Transport Cellular Response To Organic Substance Signaling Regulation Of Cell Death Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Nucleocytoplasmic Transport Neurotrophin TRK Receptor Signaling Pathway Cell Communication Neurotrophin Signaling Pathway Regulation Of Protein Localization Response To Organonitrogen Compound Response To Stress Cytokine-mediated Signaling Pathway Chaperone-mediated Protein Folding Insulin Receptor Signaling Pathway Protein Import Epidermal Growth Factor Receptor Signaling Pathway Peptidyl-amino Acid Modification ERBB Signaling Pathway Locomotion	Peptidyl-tyrosine Autophosphorylation Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Phosphorylation Regulation Of Vesicle-mediated Transport Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Microtubule Polymerization Phosphate-containing Compound Metabolic Process Positive Regulation Of Actin Cytoskeleton Reorganization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Mast Cell Degranulation Innate Immune Response Regulation Of Microtubule Polymerization Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Regulation Of Mast Cell Activation Peptidyl-amino Acid Modification Regulation Of Regulated Secretory Pathway Regulation Of Actin Cytoskeleton Reorganization Nucleotide Phosphorylation Locomotion Immune Response Protein Phosphorylation Regulation Of Microtubule Polymerization Or Depolymerization Defense Response Positive Regulation Of Myeloid Cell Differentiation
Tagcloud ?		1d4 counterpart e1c3 electrophoretic epsilon germline heavy hela iepsilon immunoglobulin initiating irs jak1 jak3 lysates mediating mobility parental promotor pronounced radiolabeled reconstitution restored shift stat6 tyrosine undergo utilized utilizing
Tagcloud (Difference) ?		1d4 counterpart e1c3 electrophoretic epsilon germline heavy hela iepsilon immunoglobulin initiating irs jak1 jak3 lysates mediating mobility parental promotor pronounced radiolabeled reconstitution restored shift stat6 tyrosine undergo utilized utilizing
Tagcloud (Intersection) ?