SIGLEC6 and FHL2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SIGLEC6	FHL2
Gene Name		sialic acid binding Ig-like lectin 6	four and a half LIM domains 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Integral Component Of Plasma Membrane Membrane	Nucleus Nucleoplasm Focal Adhesion Actin Cytoskeleton Z Disc M Band
	Molecular Function	Carbohydrate Binding	Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Identical Protein Binding Androgen Receptor Binding
	Biological Process	Cell Adhesion Cell-cell Signaling	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Transcription, DNA-templated Response To Hormone Androgen Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: FHL2 LEP TCF4	92 interactors: ADAM17 AK1 APP AR ARHGAP9 ATXN1 BANP BLZF1 BMPR2 BRCA1 CAPN1 CARD8 CCDC92 CKM CREBBP CSK CSN2 CTNNB1 DCP1A DPF2 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EIF6 EP300 ESR1 FAM129A FAM154A FHL1 FHL3 FHL5 FOXO1 GLYR1 GNG12 HAND1 HIF1A ID3 IGFBP5 IKZF4 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 MCM7 MYBPC1 NRF1 PFKM PHB2 PSEN2 PUF60 RAI2 REL REV1 RFX3 RUNX2 SAP30BP SFPQ SIGLEC6 SLC34A1 SMAD2 SMAD3 SMAD4 SP2 SRF STAT3 TNFRSF11A TRAF6 TRIM55 TRIM63 TTN WT1 ZBTB16 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF212 ZNF3 ZNF331 ZNF408 ZNF417 ZNF626 ZNF638
Entrez ID		946	2274
HPRD ID		16058	04026
Ensembl ID		ENSG00000105492	ENSG00000115641
Uniprot IDs		O43699	J3KNW4 Q14192 Q2XQU9 Q6I9R8
PDB IDs			1X4K 1X4L 2D8Z
Enriched GO Terms of Interacting Partners?		Ossification Regulation Of Gluconeogenesis Bone Mineralization Biomineral Tissue Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Secretion Regulation Of Glucose Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Cell Death Regulation Of Fat Cell Differentiation Regulation Of Lipid Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Energy Reserve Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Glucose Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cellular Response To L-ascorbic Acid Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Glutamine Transport Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Intracellular Protein Transport Cellular Response To Nutrient Levels Negative Regulation Of Gene Expression Response To Carbohydrate Negative Regulation Of Biosynthetic Process Regulation Of Insulin Secretion Glucose Homeostasis Hexose Metabolic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Hepatic Stellate Cell Activation Catenin Import Into Nucleus Regulation Of Nucleocytoplasmic Transport Regulation Of Apoptotic Process Cellular Response To Extracellular Stimulus Regulation Of Peptide Hormone Secretion Cellular Carbohydrate Metabolic Process Regulation Of Cell Death Positive Regulation Of Intracellular Transport Monosaccharide Metabolic Process Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Negative Regulation Of Vasoconstriction Atrial Cardiac Muscle Cell Development Glycerol Biosynthetic Process Negative Regulation Of Glucagon Secretion Regulation Of Lipoprotein Lipid Oxidation Regulation Of Intracellular Protein Transport Regulation Of Hormone Secretion Tissue Development	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Organ Development Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Embryo Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Developmental Process Negative Regulation Of Transcription, DNA-templated Formation Of Primary Germ Layer Negative Regulation Of Cellular Metabolic Process Tissue Development Anatomical Structure Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gastrulation Regulation Of Signaling Anatomical Structure Development Response To Organic Substance Organ Morphogenesis Embryonic Morphogenesis
Tagcloud ?		analyzing biologic deregulated fkbp11 follicles gep kb lymphoid lymphomas malt malt1 marginal mmp7 mucosa pathologic plasmacytic profiling prominent rara rgs13 signature spiked subgroups subset subsets tending translocations trisomy zone	acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly
Tagcloud (Difference) ?		analyzing biologic fkbp11 follicles gep kb lymphoid lymphomas malt malt1 marginal mmp7 mucosa pathologic plasmacytic profiling prominent rara rgs13 signature spiked subgroups subset subsets tending translocations trisomy zone	acted adapter converts cytoplasm cytoskeleton deprived direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly
Tagcloud (Intersection) ?		deregulated