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TJP2 and YWHAB
Number of citations of the paper that reports this interaction (PMID
17353931
)
246
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology)
HPRD
(in vivo)
TJP2
YWHAB
Gene Name
tight junction protein 2
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
Image
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Adherens Junction
Tight Junction
Cell Junction
Nucleus
Cytoplasm
Cytosol
Focal Adhesion
Membrane
Transcriptional Repressor Complex
Cytoplasmic Vesicle Membrane
Melanosome
Perinuclear Region Of Cytoplasm
Extracellular Vesicular Exosome
Molecular Function
Guanylate Kinase Activity
Protein Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Protein Binding, Bridging
Transcription Corepressor Activity
Protein Binding
Protein C-terminus Binding
Enzyme Binding
Protein Domain Specific Binding
Protein Complex Binding
Histone Deacetylase Binding
Phosphoserine Binding
Phosphoprotein Binding
Biological Process
Apoptotic Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Response To Organic Substance
Hippo Signaling
Nucleotide Phosphorylation
Intestinal Absorption
Establishment Of Endothelial Intestinal Barrier
Regulation Of Membrane Permeability
MAPK Cascade
Activation Of MAPKK Activity
Protein Targeting
Apoptotic Process
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Ras Protein Signal Transduction
Axon Guidance
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Gene Expression
Negative Regulation Of Protein Dephosphorylation
Hippo Signaling
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Catalytic Activity
Innate Immune Response
Negative Regulation Of Transcription, DNA-templated
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Cytoplasmic Sequestering Of Protein
Protein Heterooligomerization
Membrane Organization
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways
Apoptotic cleavage of cell adhesion proteins
Apoptotic cleavage of cellular proteins
Signaling by Hippo
Programmed Cell Death
Apoptotic execution phase
Signaling by GPCR
Signaling by FGFR in disease
Activation of BH3-only proteins
MEK activation
FCERI mediated MAPK activation
Signaling by EGFRvIII in Cancer
SHC1 events in ERBB2 signaling
Signaling by SCF-KIT
DAP12 signaling
Rap1 signalling
Gastrin-CREB signalling pathway via PKC and MAPK
SOS-mediated signalling
SHC-mediated signalling
Signaling by PDGF
Regulation of mRNA stability by proteins that bind AU-rich elements
DAP12 interactions
SHC-related events triggered by IGF1R
GRB2 events in EGFR signaling
Signaling by ERBB4
Signaling by ERBB2
Activation of BAD and translocation to mitochondria
Signaling by EGFR
Signaling by Interleukins
SHC1 events in ERBB4 signaling
Signaling by VEGF
Signalling to RAS
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
Interleukin-2 signaling
Frs2-mediated activation
Adaptive Immune System
Signaling by Leptin
Signalling to ERKs
Prolonged ERK activation events
Axon guidance
IRS-mediated signalling
Translocation of GLUT4 to the plasma membrane
IGF1R signaling cascade
VEGFA-VEGFR2 Pathway
IRS-related events triggered by IGF1R
GRB2 events in ERBB2 signaling
VEGFR2 mediated cell proliferation
RAF phosphorylates MEK
Downstream signaling of activated FGFR
Programmed Cell Death
NCAM signaling for neurite out-growth
RAF/MAP kinase cascade
Signalling to p38 via RIT and RIN
Intrinsic Pathway for Apoptosis
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Innate Immune System
Signaling by Insulin receptor
Signalling by NGF
Insulin receptor signalling cascade
SOS-mediated signalling
SHC-mediated signalling
Cytokine Signaling in Immune system
IRS-related events
Signaling by Ligand-Responsive EGFR Variants in Cancer
Tristetraprolin (TTP) destabilizes mRNA
NGF signalling via TRKA from the plasma membrane
SHC-related events
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by FGFR
ARMS-mediated activation
Signaling by Hippo
RAF activation
SHC1 events in EGFR signaling
IRS-mediated signalling
FRS2-mediated cascade
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Drugs
Diseases
GWAS
Refractive error (
23396134
)
Renal sinus fat (
22044751
)
Protein-Protein Interactions
15 interactors:
CDK6
CGN
CLDN1
CLDN2
CTNNA1
EPB41
HGS
OCLN
SAFB
SCRIB
SH3KBP1
TJP1
YWHAB
YWHAG
YWHAZ
137 interactors:
ABL1
ADAM22
AKAP13
ALS2
APP
ATP5A1
BAD
BAX
BCL2L11
BCR
BID
BRAF
C1QBP
CAMK2A
CAMK2B
CBL
CDC25A
CDC25B
CDC25C
CDK11B
CDK14
CDKN1B
CHAF1A
CRTC2
CSNK2A1
DAPK1
DHX15
DYRK1A
EDC3
EPB41
EPB41L1
EPB41L3
EXO1
FER
FRMD6
GAPVD1
GEM
HDAC5
HES1
HIST1H3A
HSP90AB1
HSPA1A
HSPA1B
HSPA5
IGF1R
IKBKB
ING1
INSR
IRS1
IRS2
ITGB1
ITGB4
KCNK15
KCNK3
KCNK9
KIAA0930
KIF1C
KIF23
KIF5B
KLC1
KRT18
LARP1
LYST
MAP3K3
MAPK7
MAPT
MARK2
MARK4
MDM4
MICALL1
MINK1
MLLT4
MLXIP
MPRIP
MST1R
OSBPL3
PARD3
PARD6B
PDCL2
PDE3B
PI4KB
PIK3R2
PIK3R4
PRKCD
PRKCG
PRKCZ
PRPF6
PTPN3
RABGEF1
RACGAP1
RADIL
RAF1
RAI14
RALGPS2
RASGRF1
RGS3
RGS7
RIN1
RIOK1
RMDN3
RNPS1
RPS6KA1
SAMSN1
SKP2
SLC4A7
SLC8A1
SLC8A2
SLC8A3
SLC9A1
SNCA
SNRNP200
SON
SRC
SRPK2
SRRM2
SRSF10
SRSF3
STK38
STK38L
TESK1
TESK2
TH
TJP2
TNFAIP3
TPD52L1
TSC1
TSC2
TUBB
UBC
UCP2
UCP3
WDR77
WEE1
YWHAE
YWHAG
ZFP36
ZFP36L1
Entrez ID
9414
7529
HPRD ID
06369
03184
Ensembl ID
ENSG00000119139
ENSG00000166913
Uniprot IDs
B7Z2R3
B7Z954
Q9UDY2
P31946
PDB IDs
2OSG
3E17
2BQ0
2C23
4DNK
Enriched GO Terms of Interacting Partners
?
Cell-cell Junction Organization
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Cell-cell Junction Assembly
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Apoptotic Process
Programmed Cell Death
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Cell Death
Death
Cell Junction Assembly
Positive Regulation Of Apoptotic Signaling Pathway
Apical Junction Assembly
Positive Regulation Of Mitochondrion Organization
Epithelial Cell Development
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Regulation Of Mitochondrion Organization
Signaling
Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules
Cell Communication
Protein Targeting
Membrane Organization
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Hippo Signaling
Enzyme Linked Receptor Protein Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Signal Transduction
Epithelial Cell Differentiation
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tight Junction Assembly
Positive Regulation Of Intracellular Transport
Negative Regulation Of ERBB Signaling Pathway
Cell Development
Cell Adhesion
Cellular Component Assembly
Protein Localization
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell-cell Signaling Involved In Cell-cell Junction Organization
Cell Dedifferentiation
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Regulation Of Signal Transduction
Positive Regulation Of Transport
Cellular Protein Localization
Execution Phase Of Apoptosis
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of ERBB Signaling Pathway
Apoptotic Signaling Pathway
Negative Regulation Of Integrin-mediated Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Phosphorylation
Regulation Of Cell Death
Cellular Response To Organic Substance
Regulation Of Phosphorus Metabolic Process
Regulation Of Kinase Activity
Cell Communication
Regulation Of Apoptotic Process
Regulation Of Signal Transduction
Regulation Of Catalytic Activity
Regulation Of Protein Phosphorylation
Response To Organic Substance
Cellular Response To Stimulus
Response To Stress
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Metabolic Process
Signaling
Protein Phosphorylation
Cell Cycle
Response To Growth Factor
Response To Stimulus
Regulation Of Cell Cycle
Regulation Of Protein Kinase Activity
Developmental Process
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Catalytic Activity
Negative Regulation Of Programmed Cell Death
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Cellular Process
Neurotrophin Signaling Pathway
Innate Immune Response
Intracellular Transport
Enzyme Linked Receptor Protein Signaling Pathway
Negative Regulation Of Cell Death
Cellular Response To Organonitrogen Compound
Signal Transduction
Cellular Response To Growth Factor Stimulus
Phosphorylation
Cellular Localization
Cellular Response To Insulin Stimulus
Anatomical Structure Development
Regulation Of Intracellular Signal Transduction
Response To Organonitrogen Compound
Immune System Process
Regulation Of Metabolic Process
Tagcloud
?
3gamma
actb
atp1a1
atp1a2
atp1a3
belong
confirms
constituted
gb
glioblastoma
highlights
hsp90aa1
hspa8
icpl
identity
isolate
lethal
network
outside
peri
pump
quantification
redundant
researches
trails
trying
tumoral
ywhag
ywhaz
Tagcloud (Difference)
?
3gamma
actb
atp1a1
atp1a2
atp1a3
belong
confirms
constituted
gb
glioblastoma
highlights
hsp90aa1
hspa8
icpl
identity
isolate
lethal
network
outside
peri
pump
quantification
redundant
researches
trails
trying
tumoral
ywhag
ywhaz
Tagcloud (Intersection)
?