TJP2 and SH3KBP1

Number of citations of the paper that reports this interaction (PMID 12829691)
18

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		TJP2	SH3KBP1
Gene Name		tight junction protein 2	SH3-domain kinase binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Adherens Junction Tight Junction Cell Junction	Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Cytoplasmic Vesicle Membrane Neuron Projection Synapse
	Molecular Function	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Protein Binding, Bridging	Protein Binding SH3 Domain Binding
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Response To Organic Substance Hippo Signaling Nucleotide Phosphorylation Intestinal Absorption Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability	Endocytosis Apoptotic Process Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Cell Migration Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Pathways		Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Signaling by Hippo Programmed Cell Death Apoptotic execution phase	Signaling by the B Cell Receptor (BCR) Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
Drugs
Diseases
GWAS		Refractive error ( 23396134) Renal sinus fat ( 22044751)
Protein-Protein Interactions		15 interactors: CDK6 CGN CLDN1 CLDN2 CTNNA1 EPB41 HGS OCLN SAFB SCRIB SH3KBP1 TJP1 YWHAB YWHAG YWHAZ	45 interactors: ABI2 ARAP1 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CD2 GRB2 HCK INPP5D ITSN2 LMNA MVB12A NEDD4 PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 PSMA3 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SUMO1 SUMO2 SUMO3 SYNJ1 TAF6 TJP2 UBB UBC ZBTB7B ZNF219
Entrez ID		9414	30011
HPRD ID		06369	02301
Ensembl ID		ENSG00000119139	ENSG00000147010
Uniprot IDs		B7Z2R3 B7Z954 Q9UDY2	B7Z6E8 Q5JPT6 Q96B97
PDB IDs		2OSG 3E17	2BZ8 2K6D 2K9G 2O2O 2YDL
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cell-cell Junction Assembly Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Death Death Cell Junction Assembly Positive Regulation Of Apoptotic Signaling Pathway Apical Junction Assembly Positive Regulation Of Mitochondrion Organization Epithelial Cell Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Mitochondrion Organization Signaling Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell Communication Protein Targeting Membrane Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Hippo Signaling Enzyme Linked Receptor Protein Signaling Pathway Intrinsic Apoptotic Signaling Pathway Signal Transduction Epithelial Cell Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tight Junction Assembly Positive Regulation Of Intracellular Transport Negative Regulation Of ERBB Signaling Pathway Cell Development Cell Adhesion Cellular Component Assembly Protein Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Involved In Cell-cell Junction Organization Cell Dedifferentiation Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Signal Transduction Positive Regulation Of Transport Cellular Protein Localization Execution Phase Of Apoptosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Apoptotic Signaling Pathway Negative Regulation Of Integrin-mediated Signaling Pathway	Regulation Of Signal Transduction Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Cellular Process Signaling Signal Transduction Cell Communication Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Fibroblast Growth Factor Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Cell Death Antigen Receptor-mediated Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Apoptotic Process Immune System Process Programmed Cell Death Cellular Response To Stimulus Cell Death Death Fc Receptor Signaling Pathway Immune Response Viral Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Endocytosis Locomotion Movement Of Cell Or Subcellular Component Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Catalytic Activity Regulation Of Immune Response
Tagcloud ?			calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?			calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?