TJP2 and TJP1

Number of citations of the paper that reports this interaction (PubMedID 10026224)
0

Data Source:
HPRD (in vitro, in vivo)

		TJP2	TJP1
Description		tight junction protein 2	tight junction protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Cell-cell Contact Zone Tight Junction Anchoring Junction	Podosome Cytoplasm Cytosol Plasma Membrane Adherens Junction Gap Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Protein-containing Complex Cell Projection Apical Junction Complex Apical Part Of Cell Tight Junction Anchoring Junction
	Molecular Function	GMP Kinase Activity Protein Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Cadherin Binding Cell Adhesion Molecule Binding Protein Tyrosine Kinase Binding	Protein Binding Calmodulin Binding Cadherin Binding Cell Adhesion Molecule Binding
	Biological Process	Homotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Cell-cell Junction Organization GMP Metabolic Process GDP Metabolic Process Intestinal Absorption Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Cell-cell Adhesion Protein Localization To Cell-cell Junction Positive Regulation Of Blood-brain Barrier Permeability	Cell-cell Junction Assembly Positive Regulation Of Cell Population Proliferation Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Actomyosin Structure Organization Adherens Junction Maintenance Maintenance Of Blood-brain Barrier Ameloblast Differentiation Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Protein Localization To Adherens Junction Establishment Of Endothelial Intestinal Barrier Cell-cell Adhesion Protein Localization To Cell-cell Junction Regulation Of Cell Junction Assembly Protein Localization To Bicellular Tight Junction Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Blood-brain Barrier Permeability Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Bicellular Tight Junction Assembly
Pathways		Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	Regulation of gap junction activity Regulation of gap junction activity Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions SARS-CoV-2 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction
Drugs
Diseases
GWAS		Macular thickness ( 30535121) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Refractive error ( 23396134 32231278) Renal sinus fat ( 22044751) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)	Central corneal thickness ( 29760442 30894546 31798171 32528159) Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943) Spleen volume ( 34128465)
Interacting Genes		16 interacting genes: CDK6 CGN CLDN1 CLDN2 CLK1 CTNNA1 EPB41 HGS HSPB1 SAFB SCRIB SH3KBP1 TJP1 YWHAB YWHAG YWHAZ	40 interacting genes: ACTA1 ACTN4 AFDN ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL1 PEA15 PTPN14 TJP2 TJP3 TRPC4 TTC3 UBN1 YBX3
Entrez ID		9414	7082
HPRD ID		06369	03002
Ensembl ID		ENSG00000119139	ENSG00000104067
Uniprot IDs		A0A3B3IU51 B7Z2R3 B7Z954 Q9UDY2	A0A087X0K9 A0A0G2JNH2 A0A7I2V5U5 A9CQZ8 B4DZK4 G3V1L9 G5E9E7 Q07157
PDB IDs		2OSG 3E17	2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ 4OEO 4OEP 4Q2Q 4YYX
Enriched GO Terms of Interacting Partners?		Cell Junction Anchoring Junction Cadherin Binding Cell-cell Junction Focal Adhesion Protein Kinase C Inhibitor Activity Cell-cell Adhesion Cell-cell Junction Assembly Tight Junction Bicellular Tight Junction Protein Localization To Adherens Junction Protein Sequestering Activity Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Cell-cell Junction Organization Structural Molecule Activity Protein Targeting Protein Domain Specific Binding Regulation Of Multicellular Organismal Process Basolateral Plasma Membrane Regulation Of Intestinal Absorption Protein Localization To Cell Junction Intracellular Protein Localization Cell Adhesion Cell Junction Assembly Establishment Of Endothelial Intestinal Barrier Regulation Of Developmental Process Regulation Of Translational Initiation Protein Localization To Cell-cell Junction Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Bicellular Tight Junction Assembly Epithelial Cell Development Regulation Of Protein Localization To Nucleus Maintenance Of Blood-brain Barrier Establishment Of Endothelial Barrier Phosphoprotein Binding Identical Protein Binding Anatomical Structure Homeostasis Tissue Homeostasis Adherens Junction Establishment Of Protein Localization Endothelial Cell Development Cell Junction Organization Bicellular Tight Junction Assembly Cyclin D2-CDK6 Complex Negative Regulation Of Protein Kinase C Signaling Protein Kinase C Binding Negative Regulation Of Translational Initiation Xenobiotic Transport Across Blood-nerve Barrier Cellular Response To Glucose Starvation	Anchoring Junction Bicellular Tight Junction Cell-cell Junction Organization Tight Junction Cell-cell Junction Assembly Cell Junction Organization Cell Junction Assembly Cell-cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Bicellular Tight Junction Assembly Cell Junction Tight Junction Assembly Maintenance Of Blood-brain Barrier Tight Junction Organization Cell Adhesion Plasma Membrane Apicolateral Plasma Membrane Connexin Complex Gap Junction Channel Activity Structural Molecule Activity Anatomical Structure Homeostasis Tissue Homeostasis Gap Junction Establishment Of Endothelial Intestinal Barrier Establishment Of Endothelial Barrier Endothelial Cell Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Gap Junction Assembly Cadherin Binding Cell-cell Contact Zone Lateral Plasma Membrane Cell Development Cellular Component Assembly Multicellular Organismal-level Homeostasis Paracellular Transport System Process Epithelial Cell Development Cell-cell Signaling Identical Protein Binding Intercellular Transport Basolateral Plasma Membrane Signaling Cell Communication Membrane Intercalated Disc Regulation Of Locomotion Homeostatic Process Cell Communication By Electrical Coupling Involved In Cardiac Conduction Developmental Process
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