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TJP2 and CDK6
Number of citations of the paper that reports this interaction (PMID
22094256
)
37
Data Source:
BioGRID
(enzymatic study)
TJP2
CDK6
Gene Name
tight junction protein 2
cyclin-dependent kinase 6
Image
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Adherens Junction
Tight Junction
Cell Junction
Cyclin-dependent Protein Kinase Holoenzyme Complex
Ruffle
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Guanylate Kinase Activity
Protein Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Protein Binding, Bridging
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Cyclin Binding
Biological Process
Apoptotic Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Response To Organic Substance
Hippo Signaling
Nucleotide Phosphorylation
Intestinal Absorption
Establishment Of Endothelial Intestinal Barrier
Regulation Of Membrane Permeability
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Positive Regulation Of Cell-matrix Adhesion
Type B Pancreatic Cell Development
Protein Phosphorylation
Cell Cycle Arrest
Notch Signaling Pathway
Negative Regulation Of Cell Proliferation
Response To Virus
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Astrocyte Development
Dentate Gyrus Development
Lateral Ventricle Development
T Cell Differentiation In Thymus
Gliogenesis
Cell Dedifferentiation
Negative Regulation Of Cell Differentiation
Negative Regulation Of Myeloid Cell Differentiation
Regulation Of Erythrocyte Differentiation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Cell Cycle
Positive Regulation Of Fibroblast Proliferation
Generation Of Neurons
Negative Regulation Of Epithelial Cell Proliferation
Cell Division
Hematopoietic Stem Cell Differentiation
Regulation Of Cell Motility
Negative Regulation Of Cellular Senescence
Pathways
Apoptotic cleavage of cell adhesion proteins
Apoptotic cleavage of cellular proteins
Signaling by Hippo
Programmed Cell Death
Apoptotic execution phase
Cyclin D associated events in G1
Oxidative Stress Induced Senescence
G1 Phase
Cellular Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Mitotic G1-G1/S phases
Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Refractive error (
23396134
)
Renal sinus fat (
22044751
)
Height (
20881960
19343178
23563607
18391950
18391951
18391952
)
Rheumatoid arthritis (
18794853
)
White blood cell count (
20139978
21738479
)
White blood cell types (
21738478
)
Protein-Protein Interactions
15 interactors:
CDK6
CGN
CLDN1
CLDN2
CTNNA1
EPB41
HGS
OCLN
SAFB
SCRIB
SH3KBP1
TJP1
YWHAB
YWHAG
YWHAZ
92 interactors:
ABI2
ANKRD12
AR
ATF6B
ATXN1
BCL11A
CASC3
CBY1
CCND1
CCND3
CDC37
CDC6
CDK7
CDKN1A
CDKN2A
CDKN2B
CDKN2C
CDKN2D
CLASRP
CNOT7
CTNNB1
DAB1
DDIT3
DEDD2
EBF4
EIF4ENIF1
ELK1
EZH2
FOXM1
FOXO3
HIST1H1A
HSF1
ISL1
KIF26B
KLF10
LPIN1
MCM10
MCM2
MEF2D
MLLT3
MSL3
MYC
MZF1
N4BP1
NFATC3
NIPBL
NUMA1
PCNA
PML
POGZ
PPARGC1A
PPHLN1
PPM1B
PPP2CA
PRX
PSMA3
RB1
RBL1
RBL2
RBM23
RUNX1
SENP3
SIRT1
SLBP
SNIP1
SORBS1
SOX10
SOX5
SRSF1
SRSF11
SRSF12
SRSF2
SRSF7
SSBP2
SYNPO2
TCEB3B
TFDP1
TGFBR1
TJP2
TPX2
TRA2A
TRA2B
TRAK1
UHRF2
VGLL4
ZEB1
ZFP36
ZMYM3
ZNF101
ZNF174
ZNF335
ZSCAN1
Entrez ID
9414
1021
HPRD ID
06369
04533
Ensembl ID
ENSG00000119139
ENSG00000105810
Uniprot IDs
B7Z2R3
B7Z954
Q9UDY2
A4D1G0
Q00534
PDB IDs
2OSG
3E17
1BI7
1BI8
1BLX
1G3N
1JOW
1XO2
2EUF
2F2C
3NUP
3NUX
4AUA
4EZ5
Enriched GO Terms of Interacting Partners
?
Cell-cell Junction Organization
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Cell-cell Junction Assembly
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Apoptotic Process
Programmed Cell Death
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Cell Death
Death
Cell Junction Assembly
Positive Regulation Of Apoptotic Signaling Pathway
Apical Junction Assembly
Positive Regulation Of Mitochondrion Organization
Epithelial Cell Development
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Regulation Of Mitochondrion Organization
Signaling
Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules
Cell Communication
Protein Targeting
Membrane Organization
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Hippo Signaling
Enzyme Linked Receptor Protein Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Signal Transduction
Epithelial Cell Differentiation
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tight Junction Assembly
Positive Regulation Of Intracellular Transport
Negative Regulation Of ERBB Signaling Pathway
Cell Development
Cell Adhesion
Cellular Component Assembly
Protein Localization
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell-cell Signaling Involved In Cell-cell Junction Organization
Cell Dedifferentiation
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Regulation Of Signal Transduction
Positive Regulation Of Transport
Cellular Protein Localization
Execution Phase Of Apoptosis
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of ERBB Signaling Pathway
Apoptotic Signaling Pathway
Negative Regulation Of Integrin-mediated Signaling Pathway
RNA Metabolic Process
Gene Expression
Transcription, DNA-templated
RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Cell Cycle
Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Cell Cycle Process
Positive Regulation Of Cellular Biosynthetic Process
Mitotic Cell Cycle
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Cell Cycle
Mitotic Cell Cycle Process
Regulation Of Phosphorylation
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cellular Protein Metabolic Process
Regulation Of Phosphorus Metabolic Process
Cellular Metabolic Process
RNA Processing
Regulation Of Protein Metabolic Process
Regulation Of Cellular Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud
?
a134c
abp
allelic
ankyrin
balb
cdkn2a
cdkn2b
cdkn2c
cdnas
chr
congenic
d2
dba
g232a
ifna
inbred
inefficient
ink4c
le
multigenic
mus
p15
p16
p18
pctr1
plasmacytoma
pristane
spretus
typed
Tagcloud (Difference)
?
a134c
abp
allelic
ankyrin
balb
cdkn2a
cdkn2b
cdkn2c
cdnas
chr
congenic
d2
dba
g232a
ifna
inbred
inefficient
ink4c
le
multigenic
mus
p15
p16
p18
pctr1
plasmacytoma
pristane
spretus
typed
Tagcloud (Intersection)
?