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TJP2 and CGN
Number of citations of the paper that reports this interaction (PMID
10613913
)
38
Data Source:
HPRD
(in vitro, in vivo)
TJP2
CGN
Gene Name
tight junction protein 2
cingulin
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Adherens Junction
Tight Junction
Cell Junction
Tight Junction
Myosin Complex
Cell Junction
Molecular Function
Guanylate Kinase Activity
Protein Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Protein Binding, Bridging
Motor Activity
Actin Binding
Protein Binding
Microtubule Binding
Biological Process
Apoptotic Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Response To Organic Substance
Hippo Signaling
Nucleotide Phosphorylation
Intestinal Absorption
Establishment Of Endothelial Intestinal Barrier
Regulation Of Membrane Permeability
Microtubule Cytoskeleton Organization
Epithelial Cell Morphogenesis
Transforming Growth Factor Beta Receptor Signaling Pathway
Biological_process
Metabolic Process
Tight Junction Assembly
Pathways
Apoptotic cleavage of cell adhesion proteins
Apoptotic cleavage of cellular proteins
Signaling by Hippo
Programmed Cell Death
Apoptotic execution phase
Loss of Function of TGFBR2 in Cancer
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Refractive error (
23396134
)
Renal sinus fat (
22044751
)
Protein-Protein Interactions
15 interactors:
CDK6
CGN
CLDN1
CLDN2
CTNNA1
EPB41
HGS
OCLN
SAFB
SCRIB
SH3KBP1
TJP1
YWHAB
YWHAG
YWHAZ
6 interactors:
ARHGEF2
F11R
LNX1
TJP1
TJP2
YWHAG
Entrez ID
9414
57530
HPRD ID
06369
10827
Ensembl ID
ENSG00000119139
ENSG00000143375
Uniprot IDs
B7Z2R3
B7Z954
Q9UDY2
Q9P2M7
PDB IDs
2OSG
3E17
Enriched GO Terms of Interacting Partners
?
Cell-cell Junction Organization
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Cell-cell Junction Assembly
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Apoptotic Process
Programmed Cell Death
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Cell Death
Death
Cell Junction Assembly
Positive Regulation Of Apoptotic Signaling Pathway
Apical Junction Assembly
Positive Regulation Of Mitochondrion Organization
Epithelial Cell Development
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Regulation Of Mitochondrion Organization
Signaling
Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules
Cell Communication
Protein Targeting
Membrane Organization
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Hippo Signaling
Enzyme Linked Receptor Protein Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Signal Transduction
Epithelial Cell Differentiation
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tight Junction Assembly
Positive Regulation Of Intracellular Transport
Negative Regulation Of ERBB Signaling Pathway
Cell Development
Cell Adhesion
Cellular Component Assembly
Protein Localization
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell-cell Signaling Involved In Cell-cell Junction Organization
Cell Dedifferentiation
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Regulation Of Signal Transduction
Positive Regulation Of Transport
Cellular Protein Localization
Execution Phase Of Apoptosis
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of ERBB Signaling Pathway
Apoptotic Signaling Pathway
Negative Regulation Of Integrin-mediated Signaling Pathway
Establishment Of Endothelial Intestinal Barrier
Establishment Of Endothelial Barrier
Endothelial Cell Development
Endothelial Cell Differentiation
Endothelium Development
Epithelial Cell Development
Intestinal Absorption
Hippo Signaling
Regulation Of Membrane Permeability
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Response To Organic Substance
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Execution Phase Of Apoptosis
Epithelial Cell Differentiation
Cell-cell Signaling Involved In Cell-cell Junction Organization
Cell Differentiation
Digestion
Cell-cell Junction Assembly
Intracellular Signal Transduction
Cellular Response To Organic Substance
Cellular Response To Muramyl Dipeptide
Membrane Organization
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Response To Magnetism
Cell Junction Assembly
Regulation Of Organelle Organization
Cell-cell Junction Organization
Epithelium Development
Response To Abiotic Stimulus
Anatomical Structure Development
Regulation Of Rho GTPase Activity
Regulation Of Response To Osmotic Stress
Cellular Hyperosmotic Response
Blood Circulation
Signal Transduction
Cellular Response To Peptide
Regulation Of Rho Protein Signal Transduction
Apoptotic Signaling Pathway
Developmental Process
Cellular Protein Localization
Negative Regulation Of Vascular Permeability
Negative Regulation Of Rho GTPase Activity
Signaling
Negative Regulation Of Necroptotic Process
Cell Communication
Establishment Of Protein Localization
Positive Regulation Of Rap GTPase Activity
Tagcloud
?
ac
attenuate
believed
blots
caspase
cerebellar
cho
cytochrome
cytosol
cytosolic
devd
ensuing
extracts
fmk
granule
hydroxydopamine
involves
lacking
laddering
mitochondria
neurotoxicity
ohda
pna
points
precedes
protease
reveal
ultimately
zvad
Tagcloud (Difference)
?
ac
attenuate
believed
blots
caspase
cerebellar
cho
cytochrome
cytosol
cytosolic
devd
ensuing
extracts
fmk
granule
hydroxydopamine
involves
lacking
laddering
mitochondria
neurotoxicity
ohda
pna
points
precedes
protease
reveal
ultimately
zvad
Tagcloud (Intersection)
?