ITGB1BP1 and LRP2

Number of citations of the paper that reports this interaction (PubMedID 10827173)
0

Data Source:
HPRD (two hybrid, in vitro)

		ITGB1BP1	LRP2
Description		integrin subunit beta 1 binding protein 1	LDL receptor related protein 2
Image
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Nuclear Body Lamellipodium Centriolar Satellite Cell Projection Perinuclear Region Of Cytoplasm Cell Periphery	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Brush Border Clathrin-coated Pit External Side Of Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Brush Border Membrane Endosome Lumen Cell Projection Receptor Complex Apical Part Of Cell Extracellular Exosome
	Molecular Function	GDP-dissociation Inhibitor Activity Integrin Binding Protein Binding Kinase Binding Protein Kinase Binding	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding SH3 Domain Binding Insulin-like Growth Factor I Binding Cargo Receptor Activity Hormone Binding Metal Ion Binding Protein-folding Chaperone Binding Protein Transporter Activity
	Biological Process	Angiogenesis Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Cell Adhesion Cell-matrix Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Fibroblast Migration Cell Migration Cell Differentiation Negative Regulation Of Cell Migration Biomineral Tissue Development Negative Regulation Of Protein Binding Activation Of Protein Kinase B Activity Integrin Activation Regulation Of Cell Adhesion Mediated By Integrin Tube Formation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of GTPase Activity Receptor Clustering Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Myoblast Migration Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cell Division Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Membrane Protein Localization To Plasma Membrane Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Protein Targeting To Membrane Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Protein Targeting To Membrane Blood Vessel Diameter Maintenance Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Integrin-mediated Signaling Pathway	Retinoid Metabolic Process Kidney Development Neural Tube Closure Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Ventricular Septum Development Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Nervous System Development Heart Development Sensory Perception Of Sound Cell Population Proliferation Male Gonad Development Gene Expression Protein Transport Cobalamin Transport Metal Ion Transport Negative Regulation Of BMP Signaling Pathway Forebrain Development Diol Metabolic Process Aorta Development Vitamin D Metabolic Process Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Leptin Transcytosis Positive Regulation Of Neurogenesis Vitamin Transport Vagina Development Coronary Vasculature Development Coronary Artery Morphogenesis Pulmonary Artery Morphogenesis Positive Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Growth Factor Stimulus Amyloid-beta Clearance Neuron Projection Arborization Transport Across Blood-brain Barrier Folate Import Across Plasma Membrane Cranial Skeletal System Development Positive Regulation Of Lysosomal Protein Catabolic Process
Pathways			Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport Transport of RCbl within the body
Drugs			Urokinase Insulin human
Diseases			Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome
GWAS			Anorexia nervosa ( 21079607) Blood pressure (smoking interaction) ( 25189868) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443 29403010) Estimated glomerular filtration rate ( 29779033 31451708 31152163 31015462 30604766 29124443) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 29403010 27588450) Glomerular filtration rate (creatinine) ( 26831199 28452372) Gout ( 33832965) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hyperuricemia ( 29124443) Macular thickness ( 30535121) Optic disc size ( 31809533) Proteinuria ( 30476138) Proteinuria (mild) ( 30476138) Proteinuria (moderate to severe) ( 30476138) Relapse in multiple sclerosis ( 28739605) Serum creatinine levels ( 29779033) Serum uric acid levels ( 30993211 29403010 29124443) Urate levels ( 20139978 31578528)
Interacting Genes		19 interacting genes: APP CAMK2A CCDC33 DLD EEF1A1 FAF1 FIGNL1 GSDME ITGB1 KRIT1 LRP1 LRP2 LRP8 RHOH SLC35F5 SMO SMURF1 SMURF2 UTRN	53 interacting genes: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CDC42 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 DYRK1A GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RAC1 RBP1 RHOA SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR USP40
Entrez ID		9270	4036
HPRD ID		06194	02509
Ensembl ID		ENSG00000119185	ENSG00000081479
Uniprot IDs		B4DQY5 O14713	P98164 Q7Z5C0 Q7Z5C1
PDB IDs		4DX8 4DX9 4JIF	2M0P
Enriched GO Terms of Interacting Partners?		Apolipoprotein Binding Regulation Of Apoptotic Process Astrocyte Activation Low-density Lipoprotein Particle Receptor Activity Regulation Of Programmed Cell Death Receptor Complex Cargo Receptor Activity Positive Regulation Of Neurogenesis Regulation Of Cell Migration Astrocyte Activation Involved In Immune Response Positive Regulation Of Cell Development Negative Regulation Of Signal Transduction Regulation Of Cell Motility Positive Regulation Of Nervous System Development Positive Regulation Of Lysosomal Protein Catabolic Process Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Regulation Of Spontaneous Synaptic Transmission Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Neurogenesis Regulation Of Protein Catabolic Process Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Lysosomal Protein Catabolic Process Clathrin-coated Pit Retinoid Metabolic Process Endocytic Vesicle Membrane Positive Regulation Of Protein Catabolic Process Diterpenoid Metabolic Process Regulation Of Nervous System Development Endocytosis Protein Kinase Binding Cellular Response To Cholesterol Dendrite Terpenoid Metabolic Process Regulation Of Neural Precursor Cell Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Heparan Sulfate Proteoglycan Binding Neuron Projection Morphogenesis Developmental Process Transcytosis	Low-density Lipoprotein Particle Receptor Binding Regulation Of Endocytosis Heparin Binding Regulation Of Cell-substrate Adhesion Very-low-density Lipoprotein Particle Regulation Of Receptor-mediated Endocytosis Amyloid-beta Binding Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Biological Quality Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Vesicle-mediated Transport Protein Kinase Binding Negative Regulation Of Fibrinolysis Regulation Of Locomotion Establishment Or Maintenance Of Cell Polarity Signal Transduction Chylomicron Regulation Of Cell Migration Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Cellular Component Organization Regulation Of Cell Motility Regulation Of Cell-matrix Adhesion Regulation Of Cell Projection Organization Receptor Ligand Activity Intermediate-density Lipoprotein Particle Regulation Of Endothelial Cell Migration Positive Regulation Of Amyloid Fibril Formation Negative Regulation Of Signaling Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Regulation Of Fibrinolysis Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Extracellular Exosome Positive Regulation Of Cell Motility Positive Regulation Of Transport Regulation Of Amyloid-beta Clearance Regulation Of Proteolysis Extracellular Region Regulation Of Transport Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Locomotion Positive Regulation Of Cellular Component Organization Endosome Lumen Cell Periphery Cell Adhesion Positive Regulation Of Receptor-mediated Endocytosis
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