ITGB1BP1 and SLC35F5

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		ITGB1BP1	SLC35F5
Description		integrin subunit beta 1 binding protein 1	solute carrier family 35 member F5
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Nuclear Body Lamellipodium Centriolar Satellite Cell Projection Perinuclear Region Of Cytoplasm Cell Periphery	Membrane
	Molecular Function	GDP-dissociation Inhibitor Activity Integrin Binding Protein Binding Kinase Binding Protein Kinase Binding
	Biological Process	Angiogenesis Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Cell Adhesion Cell-matrix Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Fibroblast Migration Cell Migration Cell Differentiation Negative Regulation Of Cell Migration Biomineral Tissue Development Negative Regulation Of Protein Binding Activation Of Protein Kinase B Activity Integrin Activation Regulation Of Cell Adhesion Mediated By Integrin Tube Formation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of GTPase Activity Receptor Clustering Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Myoblast Migration Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cell Division Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Membrane Protein Localization To Plasma Membrane Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Protein Targeting To Membrane Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Protein Targeting To Membrane Blood Vessel Diameter Maintenance Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Integrin-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		19 interacting genes: APP CAMK2A CCDC33 DLD EEF1A1 FAF1 FIGNL1 GSDME ITGB1 KRIT1 LRP1 LRP2 LRP8 RHOH SLC35F5 SMO SMURF1 SMURF2 UTRN	1 interacting genes: ITGB1BP1
Entrez ID		9270	80255
HPRD ID		06194	11579
Ensembl ID		ENSG00000119185	ENSG00000115084
Uniprot IDs		B4DQY5 O14713	B8ZZV6 B8ZZY4 Q8WV83
PDB IDs		4DX8 4DX9 4JIF
Enriched GO Terms of Interacting Partners?		Apolipoprotein Binding Regulation Of Apoptotic Process Astrocyte Activation Low-density Lipoprotein Particle Receptor Activity Regulation Of Programmed Cell Death Receptor Complex Cargo Receptor Activity Positive Regulation Of Neurogenesis Regulation Of Cell Migration Astrocyte Activation Involved In Immune Response Positive Regulation Of Cell Development Negative Regulation Of Signal Transduction Regulation Of Cell Motility Positive Regulation Of Nervous System Development Positive Regulation Of Lysosomal Protein Catabolic Process Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Regulation Of Spontaneous Synaptic Transmission Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Neurogenesis Regulation Of Protein Catabolic Process Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Lysosomal Protein Catabolic Process Clathrin-coated Pit Retinoid Metabolic Process Endocytic Vesicle Membrane Positive Regulation Of Protein Catabolic Process Diterpenoid Metabolic Process Regulation Of Nervous System Development Endocytosis Protein Kinase Binding Cellular Response To Cholesterol Dendrite Terpenoid Metabolic Process Regulation Of Neural Precursor Cell Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Heparan Sulfate Proteoglycan Binding Neuron Projection Morphogenesis Developmental Process Transcytosis	Negative Regulation Of Protein Binding Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Activation Of Protein Kinase B Activity Regulation Of Protein Targeting To Membrane Regulation Of Fibroblast Migration Negative Regulation Of Cell-matrix Adhesion Regulation Of Protein Binding Integrin Activation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Activation Of Protein Kinase Activity Negative Regulation Of Fibroblast Migration Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Protein Targeting To Membrane Endothelial Cell Proliferation Positive Regulation Of Notch Signaling Pathway Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Focal Adhesion Assembly Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Muscle Cell Migration Myoblast Migration Negative Regulation Of Protein Targeting To Membrane Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis GDP-dissociation Inhibitor Activity Response To Fibroblast Growth Factor Receptor Clustering Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell-substrate Adhesion Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Focal Adhesion Assembly Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell-substrate Junction Organization Negative Regulation Of Kinase Activity Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Protein Kinase Activity Negative Regulation Of Protein Phosphorylation Cell Periphery Kinase Binding Positive Regulation Of Cell Division Regulation Of Notch Signaling Pathway Ruffle Regulation Of Stress Fiber Assembly Cell-matrix Adhesion Positive Regulation Of Cell Junction Assembly
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