ITGB1BP1 and DLD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ITGB1BP1	DLD
Description		integrin subunit beta 1 binding protein 1	dihydrolipoamide dehydrogenase
Image
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Nuclear Body Lamellipodium Centriolar Satellite Cell Projection Perinuclear Region Of Cytoplasm Cell Periphery	Acrosomal Vesicle Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cilium Cytoplasmic Vesicle Motile Cilium Cell Projection Acrosomal Matrix Oxoglutarate Dehydrogenase Complex Pyruvate Dehydrogenase Complex Branched-chain Alpha-ketoacid Dehydrogenase Complex Oxoadipate Dehydrogenase Complex Acetyltransferase Complex
	Molecular Function	GDP-dissociation Inhibitor Activity Integrin Binding Protein Binding Kinase Binding Protein Kinase Binding	Dihydrolipoyl Dehydrogenase (NADH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, NAD(P) As Acceptor Flavin Adenine Dinucleotide Binding
	Biological Process	Angiogenesis Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Cell Adhesion Cell-matrix Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Fibroblast Migration Cell Migration Cell Differentiation Negative Regulation Of Cell Migration Biomineral Tissue Development Negative Regulation Of Protein Binding Activation Of Protein Kinase B Activity Integrin Activation Regulation Of Cell Adhesion Mediated By Integrin Tube Formation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of GTPase Activity Receptor Clustering Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Myoblast Migration Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cell Division Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Membrane Protein Localization To Plasma Membrane Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Protein Targeting To Membrane Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Protein Targeting To Membrane Blood Vessel Diameter Maintenance Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Integrin-mediated Signaling Pathway	Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Metabolic Process 2-oxoglutarate Metabolic Process Mitochondrial Electron Transport, NADH To Ubiquinone Proteolysis Gastrulation Branched-chain Amino Acid Catabolic Process Regulation Of Membrane Potential Sperm Capacitation 2-oxoglutarate Decarboxylation To Succinyl-CoA Branched-chain Alpha-keto Acid Decarboxylation To Branched-chain Acyl-CoA
Pathways			Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Glycine degradation Branched-chain amino acid catabolism Mitochondrial protein degradation OGDH complex synthesizes succinyl-CoA from 2-OG OADH complex synthesizes glutaryl-CoA from 2-OA BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV PDH complex synthesizes acetyl-CoA from PYR Loss-of-function mutations in DBT cause MSUD2 Loss-of-function mutations in DLD cause MSUD3/DLDD Branched-chain ketoacid dehydrogenase kinase deficiency H139Hfs13* PPM1K causes a mild variant of MSUD
Drugs			NADH Flavin adenine dinucleotide
Diseases			Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome Maple syrup urine disease (MSUD)
GWAS			Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 19122664 20228799 23128233 28067908) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		19 interacting genes: APP CAMK2A CCDC33 DLD EEF1A1 FAF1 FIGNL1 GSDME ITGB1 KRIT1 LRP1 LRP2 LRP8 RHOH SLC35F5 SMO SMURF1 SMURF2 UTRN	5 interacting genes: ITGB1BP1 OGDH OGT PDHX SLC2A4
Entrez ID		9270	1738
HPRD ID		06194	02006
Ensembl ID		ENSG00000119185	ENSG00000091140
Uniprot IDs		B4DQY5 O14713	A0A024R713 E9PEX6 P09622
PDB IDs		4DX8 4DX9 4JIF	1ZMC 1ZMD 1ZY8 2F5Z 3RNM 5J5Z 5NHG 6HG8 6I4P 6I4Q 6I4R 6I4S 6I4T 6I4U 6I4Z 7PSC 7ZYT
Enriched GO Terms of Interacting Partners?		Apolipoprotein Binding Regulation Of Apoptotic Process Astrocyte Activation Low-density Lipoprotein Particle Receptor Activity Regulation Of Programmed Cell Death Receptor Complex Cargo Receptor Activity Positive Regulation Of Neurogenesis Regulation Of Cell Migration Astrocyte Activation Involved In Immune Response Positive Regulation Of Cell Development Negative Regulation Of Signal Transduction Regulation Of Cell Motility Positive Regulation Of Nervous System Development Positive Regulation Of Lysosomal Protein Catabolic Process Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Regulation Of Spontaneous Synaptic Transmission Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Neurogenesis Regulation Of Protein Catabolic Process Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Lysosomal Protein Catabolic Process Clathrin-coated Pit Retinoid Metabolic Process Endocytic Vesicle Membrane Positive Regulation Of Protein Catabolic Process Diterpenoid Metabolic Process Regulation Of Nervous System Development Endocytosis Protein Kinase Binding Cellular Response To Cholesterol Dendrite Terpenoid Metabolic Process Regulation Of Neural Precursor Cell Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Heparan Sulfate Proteoglycan Binding Neuron Projection Morphogenesis Developmental Process Transcytosis	Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors Pyruvate Metabolic Process Acyl-CoA Metabolic Process Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Olfactory Bulb Mitral Cell Layer Development Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Dihydrolipoyllysine-residue Acetyltransferase Activity Mitochondrial Membrane Thiamine Pyrophosphate Binding Carbohydrate Derivative Metabolic Process Pyramidal Neuron Development Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Tangential Migration From The Subventricular Zone To The Olfactory Bulb Sulfur Compound Metabolic Process Oxoglutarate Dehydrogenase Complex Oxoglutarate Dehydrogenase (succinyl-transferring) Activity Cerebellar Cortex Development Insulin-responsive Compartment Carbohydrate Homeostasis Dehydroascorbic Acid Transport Glucose Import In Response To Insulin Stimulus Glucose Homeostasis Vascular Process In Circulatory System Response To Insulin White Fat Cell Proliferation Fat Cell Proliferation Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Dehydrogenase Complex Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Regulation Of Cell Junction Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Activation Of Protein Kinase B Activity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Negative Regulation Of Protein Targeting To Membrane Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Transcription By Glucose Succinyl-CoA Metabolic Process D-glucose Transmembrane Transporter Activity Thalamus Development Response To Peptide Hormone NSL Complex Integrin Activation
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