ITGB1BP1 and RHOH

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ITGB1BP1	RHOH
Name		integrin subunit beta 1 binding protein 1	ras homolog family member H
Structure			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Nuclear Body Lamellipodium Centriolar Satellite Cell Projection Perinuclear Region Of Cytoplasm Cell Periphery	Immunological Synapse Cytoplasm Plasma Membrane Membrane
	Molecular Function	GDP-dissociation Inhibitor Activity Integrin Binding Protein Binding Kinase Binding Protein Kinase Binding	Nucleotide Binding GTPase Activity GTPase Inhibitor Activity Protein Binding GTP Binding Kinase Inhibitor Activity Protein Kinase Binding Small GTPase Binding
	Biological Process	Angiogenesis Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Cell Adhesion Cell-matrix Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Fibroblast Migration Cell Migration Cell Differentiation Negative Regulation Of Cell Migration Biomineral Tissue Development Negative Regulation Of Protein Binding Activation Of Protein Kinase B Activity Integrin Activation Regulation Of Cell Adhesion Mediated By Integrin Tube Formation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of GTPase Activity Receptor Clustering Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Myoblast Migration Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cell Division Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Membrane Protein Localization To Plasma Membrane Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Protein Targeting To Membrane Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Protein Targeting To Membrane Blood Vessel Diameter Maintenance Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Integrin-mediated Signaling Pathway	Regulation Of DNA-templated Transcription Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction T Cell Differentiation Negative Regulation Of Canonical NF-kappaB Signal Transduction Mast Cell Activation Positive Regulation Of T Cell Differentiation
Pathways		None	RHOH GTPase cycle
GWAS		No GWAS studies recorded	Graves' disease ( 21841780 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Metabolite levels ( 23823483 ) Multiple sclerosis ( 31604244 ) Pre-treatment viral load in HIV-1 infection ( 31219150 )
Novel Interactors		1 novel interactors: DYNC2LI1	1 novel interactors: TMEM33
Interacting Genes		19 interacting genes: APP CAMK2A CCDC33 DLD EEF1A1 FAF1 FIGNL1 GSDME ITGB1 KRIT1 LRP1 LRP2 LRP8 RHOH SLC35F5 SMO SMURF1 SMURF2 UTRN	23 interacting genes: ARHGDIA ARHGDIB ARHGDIG BANP CCNH FAM90A1 GDI1 IQUB ITGB1BP1 KANK2 KCNH2 LRIF1 MBLAC1 MTX2 PLEKHA7 RIPPLY1 SCNM1 SORL1 SUOX TCF19 TGFBR1 UTP14A XPNPEP1
Entrez ID		9270	399
HPRD ID		06194	03616
Ensembl ID		ENSG00000119185	ENSG00000168421
Uniprot IDs		B4DQY5 O14713	Q15669 Q6ICP4
PDB IDs		4DX8 4DX9 4JIF	Not available
GO Terms Enriched among Interactors		Apolipoprotein Binding Regulation Of Apoptotic Process Astrocyte Activation Low-density Lipoprotein Particle Receptor Activity Regulation Of Programmed Cell Death Receptor Complex Cargo Receptor Activity Positive Regulation Of Neurogenesis Regulation Of Cell Migration Astrocyte Activation Involved In Immune Response Positive Regulation Of Cell Development Negative Regulation Of Signal Transduction Regulation Of Cell Motility Positive Regulation Of Nervous System Development Positive Regulation Of Lysosomal Protein Catabolic Process Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Regulation Of Spontaneous Synaptic Transmission Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Neurogenesis Regulation Of Protein Catabolic Process Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Lysosomal Protein Catabolic Process Clathrin-coated Pit Retinoid Metabolic Process Endocytic Vesicle Membrane Positive Regulation Of Protein Catabolic Process Diterpenoid Metabolic Process Regulation Of Nervous System Development Endocytosis Protein Kinase Binding Cellular Response To Cholesterol Dendrite Terpenoid Metabolic Process Regulation Of Neural Precursor Cell Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Heparan Sulfate Proteoglycan Binding Neuron Projection Morphogenesis Developmental Process Transcytosis	Rho GDP-dissociation Inhibitor Activity GDP-dissociation Inhibitor Activity Negative Regulation Of Protein Targeting To Membrane Rho Protein Signal Transduction