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TIFA and IRAK1
Number of citations of the paper that reports this interaction (PubMedID
12566447
)
0
Data Source:
HPRD
(in vivo, in vitro)
TIFA
IRAK1
Description
TRAF interacting protein with forkhead associated domain
interleukin 1 receptor associated kinase 1
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Lipid Droplet
Cytosol
Plasma Membrane
Cell Surface
Endosome Membrane
Membrane
Protein-containing Complex
Molecular Function
Protein Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Heat Shock Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein Serine Kinase Activity
Biological Process
Immune System Process
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Protein Homooligomerization
Regulation Of Cytokine-mediated Signaling Pathway
Toll-like Receptor Signaling Pathway
Immune System Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of DNA-templated Transcription
Signal Transduction
Canonical NF-kappaB Signal Transduction
JNK Cascade
Toll Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Cytokine-mediated Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Cellular Response To Heat
Intracellular Signal Transduction
Interleukin-33-mediated Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Type I Interferon-mediated Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Hypoxia
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways
TAK1-dependent IKK and NF-kappa-B activation
Alpha-protein kinase 1 signaling pathway
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Transcriptional Regulation by MECP2
Interleukin-1 signaling
IRAK1 recruits IKK complex
SARS-CoV-2 activates/modulates innate and adaptive immune responses
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane
Drugs
Fostamatinib
Diseases
GWAS
Body mass index (
26426971
)
Rheumatoid arthritis (
30891314
)
Celiac disease (
22057235
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Rheumatoid arthritis (
23143596
24390342
32723749
)
Rheumatoid arthritis (ACPA-positive) (
23143596
)
Systemic lupus erythematosus (
19838195
26502338
26606652
26663301
33272962
)
Interacting Genes
25 interacting genes:
ALPK1
AP1M1
ARHGEF39
DVL2
GSDME
IRAK1
KANK2
LNX1
LNX2
NIF3L1
NTAQ1
NUDT18
NXF1
PRKAA2
RIPPLY3
RPL9
SDCBP
SDCBP2
TIFAB
TNFAIP3
TNFAIP8
TRAF1
TRAF2
TRAF6
TXN2
52 interacting genes:
AKT1
BCL10
BTK
CCDC47
FADD
H3-4
HRAS
HSP90AA1
IKBKG
IL1RAP
IRAK1BP1
IRAK2
IRAK3
IRAK4
IRF4
IRF7
ITGAM
JUN
MAP3K7
MAPK14
MAPK8
MBP
MYD88
NLRP12
NTRK3
OPTN
PELI1
PELI2
PELI3
PPP1CC
PPP3CB
PRDX1
PRKCI
PRKCZ
RIPK2
SIGIRR
SQSTM1
STAT3
STING1
SUMO1
TAB2
TBKBP1
TICAM2
TIFA
TLR2
TLR4
TOLLIP
TRAF4
TRAF6
TRIM32
USP20
YTHDC2
Entrez ID
92610
3654
HPRD ID
09835
02235
Ensembl ID
ENSG00000145365
ENSG00000184216
Uniprot IDs
Q96CG3
D3YTB5
P51617
PDB IDs
4YM4
4ZGI
5ZUJ
6A33
6BFN
Enriched GO Terms of Interacting Partners
?
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Intracellular Signal Transduction
Innate Immune Response-activating Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Identical Protein Binding
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Activation Of Innate Immune Response
Tumor Necrosis Factor Receptor Binding
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of DNA-binding Transcription Factor Activity
Lipopolysaccharide-mediated Signaling Pathway
Ubiquitin-protein Transferase Activity
Positive Regulation Of Immune Response
Positive Regulation Of Signal Transduction
Toll-like Receptor Signaling Pathway
Regulation Of JNK Cascade
Interleukin-33-mediated Signaling Pathway
Positive Regulation Of Innate Immune Response
Tumor Necrosis Factor-mediated Signaling Pathway
Thioesterase Binding
CD40 Signaling Pathway
Interleukin-17-mediated Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Interleukin-2 Production
CD40 Receptor Complex
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of JUN Kinase Activity
Regulation Of Programmed Cell Death
Immune Response-activating Signaling Pathway
Phosphatidylinositol-4,5-bisphosphate Binding
Signaling Adaptor Activity
Regulation Of Apoptotic Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Cell Death
Programmed Cell Death
Immune Response-regulating Signaling Pathway
Intracellular Receptor Signaling Pathway
Activation Of Immune Response
Regulation Of Immune Response
Regulation Of Innate Immune Response
Positive Regulation Of JNK Cascade
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of MAPK Cascade
Positive Regulation Of Defense Response
Positive Regulation Of Immune System Process
Regulation Of Signal Transduction
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Pattern Recognition Receptor Signaling Pathway
Immune System Process
Activation Of Innate Immune Response
Positive Regulation Of Defense Response
Positive Regulation Of Innate Immune Response
Innate Immune Response-activating Signaling Pathway
Defense Response
Regulation Of Innate Immune Response
Response To External Biotic Stimulus
Cell Surface Toll-like Receptor Signaling Pathway
Response To Other Organism
Immune Response-activating Signaling Pathway
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Activation Of Immune Response
Cell Surface Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Cytokine Production
Regulation Of Defense Response
Positive Regulation Of Immune Response
Positive Regulation Of Intracellular Signal Transduction
Defense Response To Other Organism
Toll-like Receptor 4 Signaling Pathway
Innate Immune Response
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Response To Stress
Positive Regulation Of Signal Transduction
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Intracellular Signal Transduction
Lipopolysaccharide-mediated Signaling Pathway
Immune Response
Regulation Of Intracellular Signal Transduction
Defense Response To Symbiont
Regulation Of Signal Transduction
Toll-like Receptor Signaling Pathway
Regulation Of Immune System Process
Regulation Of Cytokine Production
Signal Transduction
Intracellular Signaling Cassette
Signaling Adaptor Activity
Canonical NF-kappaB Signal Transduction
Positive Regulation Of Gene Expression
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Signaling
Regulation Of Cell Communication
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Tagcloud (Intersection)
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